Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nerve Tissue Proteins/genetics/ metabolism"'
Autor:
Edward W. Kraegen, Quintin Lau, Emma Polkinghorne, Sejal Amrish Patel, Mark E. Cleasby, Simon J Leslie, Greg Cooney, Nigel Turner, Aimin Xu
Publikováno v:
The Journal of Endocrinology
APPL1 is an adaptor protein that binds to both AKT and adiponectin receptors and is hypothesised to mediate the effects of adiponectin in activating downstream effectors such as AMP-activated protein kinase (AMPK). We aimed to establish whether APPL1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe840bd5fbfcfc9c9cadf361e437a92
http://europepmc.org/articles/PMC3114475
http://europepmc.org/articles/PMC3114475
Autor:
Misbah Malik-Hall, John N. Wood, Francois Rugiero, Mark D. Baker, Dongmin Shao, Kwok-Ming Yao, Kathryn S.E. Cheah, Kenji Okuse, Bjarke Abrahamsen, W.-Y.Louisa Poon
Publikováno v:
Molecular and Cellular Neurosciences
The voltage-gated sodium channel NaV1.8 is expressed exclusively in nociceptive sensory neurons and plays an important role in pain pathways. NaV1.8 cannot be functionally expressed in non-neuronal cells even in the presence of β-subunits. We have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead94c5c2a9b8e65e1f8c77f49316ed8
https://doi.org/10.1016/j.mcn.2009.07.003
https://doi.org/10.1016/j.mcn.2009.07.003
Autor:
Philippe Hammel, Sarah Garrido-Urbani, Beat A. Imhof, Paul F. Bradfield, Pierre Szepetowski, Marijana Miljkovic-Licina
Publikováno v:
FASEB Journal, Vol. 23, No 12 (2009) pp. 4105-4116
On appropriate stimuli, quiescent endothelial cells start to proliferate and form de novo blood vessels through angiogenesis. To further define molecular mechanisms accompanying the activation of endothelial cells during angiogenesis, we identified g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d5cbedb33546a2b1adf3740b5b65d5
https://doi.org/10.1096/fj.09-135202
https://doi.org/10.1096/fj.09-135202
Autor:
Gilbert Di Paolo, Laurent Cimasoni, Samuel G. Frere, Markus R. Wenk, Silvia Giovedì, Elizabeth A. Pollina, Hong Zhang, Ottavio Arancio, Katheleen Gardiner, Sergey V. Voronov, Pietro De Camilli, Cecilia Schmidt, Stylianos E. Antonarakis, Christelle Borel, Muriel T. Davisson, Ellen C. Akeson
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 105, No 27 (2008) pp. 9415-9420
Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P 2 ] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P 2 balance is required for proper neurotransmission, the phosphoinositide ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3723e9d4ff769f7c7e02356a27ea9bfe
https://doi.org/10.1073/pnas.0803756105
https://doi.org/10.1073/pnas.0803756105
Autor:
Diana Zala, Marie-Claude Gaillard, Anne D. Zurn, Emmanuel Brouillet, Patrick Aebischer, Valérie Perrin, Nicole Déglon, Alexandra Benchoua
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 3, Pp 785-798 (2005)
A lentiviral vector expressing a mutant huntingtin protein (htt171-82Q) was used to generate a chronic model of Huntington's disease (HD) in rat primary striatal cultures. In this model, the majority of neurons expressed the transgene so that Western
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a786854ae47b1e39da5cf6db8098fde
http://www.sciencedirect.com/science/article/pii/S096999610500149X
http://www.sciencedirect.com/science/article/pii/S096999610500149X
Autor:
Changchun Chen, Fausto Arellano-Carbajal, Zoltan Soltesz, Patrick Laurent, Geoffrey M. Nelson, Emmanuel D. Levy, Mario de Bono
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, 4
eLife, Vol 4 (2015)
eLife, 4
Brains organize behavior and physiology to optimize the response to threats or opportunities. We dissect how 21% O2, an indicator of surface exposure, reprograms C. elegans' global state, inducing sustained locomotory arousal and altering expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e052d94b27fdddc18c428ab067c92ec
https://pubmed.ncbi.nlm.nih.gov/25760081
https://pubmed.ncbi.nlm.nih.gov/25760081
Autor:
Iakovos Lazaridis, Achille Gravanis, Nicolaos Avlonitis, Theodora Calogeropoulou, Paschalis Efstathopoulos, Ioannis Charalampopoulos, Elias Castanas, Iosif Pediaditakis, Vassilia-Ismini Alexaki
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1001051 (2011)
PLoS Biology
PLoS Biology
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48812e311f7e961cba0e4b03ec59f8c
http://olympias.lib.uoi.gr/jspui/handle/123456789/19773
http://olympias.lib.uoi.gr/jspui/handle/123456789/19773
Autor:
Murdoch, H., Mackie, S., Collins, D. M., Hill, E. V., Bolger, G. B., Klussmann, E., Porteous, D. J., Millar, J. K., Houslay, M. D.
Publikováno v:
Murdoch, H, Mackie, S, Collins, D M, Hill, E V, Bolger, G B, Klussmann, E, Porteous, D J, Millar, J K & Houslay, M D 2007, ' Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels ', Journal of Neuroscience, vol. 27, no. 35, pp. 9513-9524 . < http://www.jneurosci.org/content/27/35/9513.full.pdf >
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::aefb6e6574ae0832ca91392db3d67d88
https://eprints.gla.ac.uk/4143/1/Murdoch4143.pdf
https://eprints.gla.ac.uk/4143/1/Murdoch4143.pdf
Autor:
Millar, J. K., Mackie, S., Clapcote, S. J., Murdoch, H., Pickard, B. S., Christie, S., Muir, W. J., Blackwood, D. H., Roder, J. C., Houslay, M. D., Porteous, D. J.
Publikováno v:
Millar, J K, Mackie, S, Clapcote, S J, Murdoch, H, Pickard, B S, Christie, S, Muir, W J, Blackwood, D H, Roder, J C, Houslay, M D & Porteous, D J 2007, ' Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness ', Journal of Physiology, vol. 584, no. Pt 2, pp. 401-405 . https://doi.org/10.1113/jphysiol.2007.140210
Disrupted in schizophrenia 1 (DISC1) is one of the most convincing genetic risk factors for major mental illness identified to date. DISC1 interacts directly with phosphodiesterase 4B (PDE4B), an independently identified risk factor for schizophrenia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::53505cb7b5dfb5badff38304674e0be4
https://www.pure.ed.ac.uk/ws/files/9104058/Disrupted_in_schizophrenia_1_and_phosphodiesterase_4B.pdf
https://www.pure.ed.ac.uk/ws/files/9104058/Disrupted_in_schizophrenia_1_and_phosphodiesterase_4B.pdf
Autor:
Stéphane Fraichard, Fawzia Baba-Aissa, Laure Guenin, Jean-François Ferveur, Yael Grosjean, Angel Acebes
Publikováno v:
Developmental Biology
Developmental Biology, Elsevier, 2007, 304 (1), pp.62-74
Developmental Biology, Elsevier, 2007, 304 (1), pp.62-74
0012-1606 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't; Adaptive animal behaviors depend upon the precise development of the nervous system that underlies them. In Drosophila melanogaster, the pan-neural prospero gene (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577b2b8288b6f5531406871371ea62c4
https://pubmed.ncbi.nlm.nih.gov/17223099
https://pubmed.ncbi.nlm.nih.gov/17223099