IDEAS: individual level differential expression analysis for single-cell RNA-seq data

Autor: Mengqi Zhang, Si Liu, Zhen Miao, Fang Han, Raphael Gottardo, Wei Sun

Publikováno v: Genome biology, vol. 23, no. 1, pp. 33
Genome Biology
Genome Biology, Vol 23, Iss 1, Pp 1-17 (2022)

We consider an increasingly popular study design where single-cell RNA-seq data are collected from multiple individuals and the question of interest is to find genes that are differentially expressed between two groups of individuals. Towards this en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666268c88da7466180a0a291811f9313
https://serval.unil.ch/resource/serval:BIB_B48AF13F6F91.P001/REF.pdf

Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent phenotype

Autor: Mohammad, Seidisarouei, Sandra, Schäble, Marijn, van Wingerden, Svenja V, Trossbach, Carsten, Korth, Tobias, Kalenscher

Publikováno v: Scientific Reports, 12(1):10182. Nature Publishing Group

Deficits in social interaction or social cognition are key phenotypes in a variety of chronic mental diseases, yet, their modeling and molecular dissection are only in their infancy. The Disrupted-in-Schizophrenia 1 (DISC1) signaling pathway is consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0e109601d37660206a17c418398202
https://research.tilburguniversity.edu/en/publications/b6f49342-f2b0-4898-913f-afcdbe35c0a8

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

Autor: Woroniuk, Anna, Porter, Andrew, White, Gavin, Newman, Daniel T., Diamantopoulou, Zoi, Waring, Thomas, Rooney, Claire, Strathdee, Douglas, Marston, Daniel J., Hahn, Klaus M., Sansom, Owen J., Zech, Tobias, Malliri, Angeliki

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Woroniuk, A, Porter, A, White, G, Newman, D, Diamantopoulou, Z, Waring, T, Rooney, C, Strathdee, D, Marston, D J, Hahn, K M, Sansom, O J, Zech, T & Malliri, A 2018, ' STEF/TIAM2 mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap ', Nature Communications, vol. 9, no. 1, 2124 . https://doi.org/10.1038/s41467-018-04404-4

The perinuclear actin cap is an important cytoskeletal structure that regulates nuclear morphology and re-orientation during front-rear polarisation. The mechanisms regulating the actin cap are currently poorly understood. Here, we demonstrate that S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1a9c042b2f09eb5875604f0bda003db
https://doaj.org/article/8a03de08b5bf41b383217440b51867d5

The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation

Autor: Heike Hänel, Stefanie Ebersberger, Cornelia Rücklé, Jan B. Heidelberger, Julian König, Jean-Yves Roignant, Ingo Ebersberger, Tobias Schmid, Anica Scholz, Mirko Brüggemann, Andrea Hildebrandt, Anke Busch, Andrea Voigt, Petra Beli, Kathi Zarnack, Susan Boerner, Martin Möckel, Annabelle Dold

Publikováno v: Genome Biology
Genome biology, vol. 20, no. 1, pp. 216
Genome Biology, Vol 20, Iss 1, Pp 1-20 (2019)

Background Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9280bdfd4f8a5776a32e583400fce74
https://doi.org/10.1186/s13059-019-1814-0

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

Autor: Van Der Klaauw, AA, Croizier, S, De Oliveira, E, Stadler, LKJ, Park, S, Kong, Y, Banton, MC, Tandon, P, Hendricks, AE, Keogh, JM, Riley, SE, Papadia, S, Henning, E, Bounds, R, Bochukova, EG, Mistry, V, O'Rahilly, S, Simerly, RB, Interval, Consortium, Uk10K, Minchin, JEN, Barroso, I, Jones, EY, Bouret, SG, Farooqi, IS

Publikováno v: Cell
Cell, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Van Der Klaauw, A A, Croizier, S, Mendes De Oliveira, E, Stadler, L K J, Park, S, Kong, Y, Banton, M C, Tandon, P, Hendricks, A E, Keogh, J M, Riley, S E, Papadia, S, Henning, E, Bounds, R, Bochukova, E G, Mistry, V, O’rahilly, S, Simerly, R B, Minchin, J E N, Barroso, I & Jones, E Y & Bouret, S G & Farooqi, I S 2019, ' Human semaphorin 3 variants link melanocortin circuit development and energy balance ', Cell, vol. 176, no. 4, pp. 729-742 . https://doi.org/10.1016/j.cell.2018.12.009
Cell, Elsevier, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Cell, vol. 176, no. 4, pp. 729-742.e18

Summary Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eb92bc3fd4ba670283a473e22557d3
https://hal.science/hal-02375383/file/S0092867418316234.pdf