Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Neruja Loganathan"'
Publikováno v:
Biochemical and Biophysical Research Communications. 658:18-26
Publikováno v:
Cells, Vol 10, Iss 11, p 3120 (2021)
The hypothalamus maintains whole-body homeostasis by integrating information from circulating hormones, nutrients and signaling molecules. Distinct neuronal subpopulations that express and secrete unique neuropeptides execute the individual functions
Externí odkaz:
https://doaj.org/article/8b318e48496a4c43b8fda1c57a3de04a
Autor:
Palida Abulizi, Neruja Loganathan, Duo Zhao, Tina Mele, Yixin Zhang, Terry Zwiep, Kexiang Liu, Xiufen Zheng
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality with no accepted method of therapy. In this study we demonstrate the role of growth differentiating factor 15 (GDF15) in septic AKI and myocardial dy
Externí odkaz:
https://doaj.org/article/937a31d3299f4a209726346449af42c7
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Phoenixin (PNX) is a newly identified reproductive peptide required for the estrous cycle. It is most highly expressed in the hypothalamus, where it is a positive regulator of gonadotropin-releasing hormone (GnRH) and kisspeptin. However, it is unkno
Externí odkaz:
https://doaj.org/article/fda353ea5952444ea574f6bfb74ddc6f
Autor:
Wenyuan He, Andy Tran, Chuck T. Chen, Neruja Loganathan, Richard P. Bazinet, Denise D. Belsham
Publikováno v:
Molecular and cellular endocrinology. 557
Accumulation of excess lipids in non-adipose tissues, such as the hypothalamus, is termed lipotoxicity and causative of free fatty acid-mediated pathology in metabolic disease. This study aimed to elucidate the molecular mechanisms behind oleate (OA)
Publikováno v:
Neuroscience. 447:41-52
Spexin (SPX) is a novel satiety factor that putatively binds the galanin receptors R2 and R3 (GalR2/R3). SPX reduces body weight, and circulating SPX is decreased in obesity. It is unknown how SPX and its receptors are regulated in the hypothalamus,
Publikováno v:
Neuroendocrinology. 111:678-695
Background: Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical and obesogen. Although limited evidence exists of the effects of BPA on hypothalamic agouti-related peptide (AgRP) levels, the mechanisms underlying these effects remain unkn
Autor:
Jennifer A Chalmers, Prasad S Dalvi, Neruja Loganathan, Emma K McIlwraith, Leigh Wellhauser, Anaies Nazarians-Armavil, Judith A Eversley, Haneesha Mohan, Priska Stahel, Satya Dash, Michael B Wheeler, Denise D Belsham
Publikováno v:
Endocrinology
MicroRNAs (miRNAs) expressed in the hypothalamus are capable of regulating energy balance and peripheral metabolism by inhibiting translation of target messenger RNAs (mRNAs). Hypothalamic insulin resistance is known to precede that in the periphery,
Publikováno v:
Molecular and Cellular Endocrinology. 485:54-60
GPR173 is a highly conserved G protein coupled receptor associated with the hypothalamic-pituitary-gonadal reproductive axis. It is expressed in the brain and ovaries, however considerable knowledge about its function remains unknown. One putative li
Publikováno v:
Molecular and Cellular Endocrinology. 479:12-19
Endocrine disrupting chemicals, such as bisphenol A (BPA), have been linked to obesity. However, the direct effect of BPA on the hypothalamic pro-opiomelanocortin (POMC) neurons, which regulate energy homeostasis, remains unexplored. We define the ef