Addressing the Intracellular Vestibule of the Plasmodial Lactate Transporter PfFNT by p-Substituted Inhibitors Amplifies In Vitro Activity.

Autor: Nerlich C; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Tiedjens F; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Hertel R; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Henke B; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Häuer S; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Panitzsch LS; Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany., Hansen K; Intana Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Germany., Franck O; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Mete A; Medsyndesign Ltd, ATIC, 5 Oakwood Drive, LE11 3QF Loughborough, U.K., Leroy D; R&D Department/Drug Discovery, ICC, Medicines for Malaria Venture (MMV), 20 Route de Pré Bois, 1215 Geneva 15, Switzerland., Schade D; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Peifer C; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Hannus S; Intana Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Germany., Becker F; Intana Bioscience GmbH, Lochhamer Str. 29a, 82152 Planegg, Germany., Wittlin S; Swiss Tropical and Public Health Institute, Kreuzstr. 2, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Spielmann T; Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany., Beitz E; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 24; Vol. 67 (20), pp. 18368-18383. Date of Electronic Publication: 2024 Oct 03.

Discovery and Development of Inhibitors of the Plasmodial FNT-Type Lactate Transporter as Novel Antimalarials.

Autor: Nerlich C; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Epalle NH; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Seick P; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany., Beitz E; Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2021 Nov 20; Vol. 14 (11). Date of Electronic Publication: 2021 Nov 20.

Do fiscal rules matter? A survey of recent evidence.

Autor: Brändle, Thomas¹ (AUTHOR), Elsener, Marc² (AUTHOR) marc.elsener@efv.admin.ch

Publikováno v: Swiss Journal of Economics & Statistics. 9/13/2024, Vol. 160 Issue 1, p1-38. 38p.

Impact of Economic Factors on the Process of Population Transition from Labour Activity to Pension in the Republic of Moldova.

Autor: Savelieva, Galina¹ savelievagalina@rambler.ru, Zaharov, Svetlana¹ zaharov.svetlana@gmail.com

Publikováno v: HOLISTICA: Journal of Business & Public Administration. Jun2024, Vol. 15 Issue 1, p47-72. 26p.

To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance.

Autor: Biswas, Pratyusa, Roy, Rini, Ghosh, Kuldip, Nath, Debjani, Samadder, Asmita, Nandi, Sisir

Publikováno v: Journal of Parasitic Diseases; Dec2024, Vol. 48 Issue 4, p671-722, 52p