Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nerissa Mendoza"'
Autor:
Robert Yauch, Dineli Wickramasinghe, Lukas Amler, Ralph Schwall, Linda Rangell, Christophe Severin, Ling Fu, Jeremy Stinson, Kanan Pujara, Thomas Holcomb, Nerissa Mendoza, Kaumudi Bhawe, Wenjing Zhu, Jiping Zha, Somasekar Seshagiri, Monica Kong-Beltran
Supplementary Figures S1-S5 from Somatic Mutations Lead to an Oncogenic Deletion of Met in Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801e3bc0d4cf95cf5288c807dd423732
https://doi.org/10.1158/0008-5472.22364528.v1
https://doi.org/10.1158/0008-5472.22364528.v1
Autor:
Robert Yauch, Dineli Wickramasinghe, Lukas Amler, Ralph Schwall, Linda Rangell, Christophe Severin, Ling Fu, Jeremy Stinson, Kanan Pujara, Thomas Holcomb, Nerissa Mendoza, Kaumudi Bhawe, Wenjing Zhu, Jiping Zha, Somasekar Seshagiri, Monica Kong-Beltran
Activating mutations in receptor tyrosine kinases play a critical role in oncogenesis. Despite evidence that Met kinase is deregulated in human cancer, the role of activating mutations in cancers other than renal papillary carcinoma has not been well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08540b2140f5ea3784c7cb22480f6146
https://doi.org/10.1158/0008-5472.c.6494228
https://doi.org/10.1158/0008-5472.c.6494228
Autor:
Amer M. Mirza, Jin-Qiu Chen, Kathleen C. Flanders, Lalage M. Wakefield, Nerissa Mendoza, Michelle A. Herrmann, Yu-an Yang
Publikováno v:
Oncotarget
// Kathleen C. Flanders 1, * , Yu-an Yang 1, * , Michelle Herrmann 1 , JinQiu Chen 1 , Nerissa Mendoza 2 , Amer M. Mirza 2 , Lalage M. Wakefield 1 1 Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland, United Stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1160d38727285170b7264dd9e7e04d1
https://doi.org/10.18632/oncotarget.9416
https://doi.org/10.18632/oncotarget.9416
Autor:
James Hnatyszyn, Maike Schmidt, Khushboo Sharma, Kevin Hestir, Nerissa Mendoza, Janine Powers
Publikováno v:
Molecular Cancer Therapeutics. 18:A033-A033
Background: Gastric cancer is the third leading cause of global cancer-related death, with 782,685 deaths in 2018 (Jemal, A. et al. 2018). Currently available treatments have limited benefits. Hence there’s a pressing need for more effective treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f79da17c443aa472aef71b612191d154
https://doi.org/10.1158/1535-7163.targ-19-a033
https://doi.org/10.1158/1535-7163.targ-19-a033
Autor:
John Corbin, Steve R. Lee, Naichi Liu, Paul D. Larsen, Nerissa Mendoza, Alexander Owyang, Genevieve Nonet, Kristen Michelson, David J. Bohmann, Amer M. Mirza, Hassan Issafras, Sandra Vanegas, Mark L. White, Daniel Bedinger, Seema S. Kantak, Robert J. Bauer, Masahisa Handa, Arnold Horwitz, Marina Roell, Lisa Gross, John J. Hunter
Publikováno v:
Journal of Biological Chemistry. 285:20607-20614
Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of monoclonal antibodies based on context-dependent attenuation to reduce pathologically high acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77194264fd73d946d170c670a65fe525
https://doi.org/10.1074/jbc.m110.115790
https://doi.org/10.1074/jbc.m110.115790
Autor:
Dineli Wickramasinghe, Ling Fu, Linda Rangell, Christophe Severin, Kanan Pujara, Robert L. Yauch, Somasekar Seshagiri, Kaumudi Bhawe, Lukas C. Amler, Jeremy Stinson, Nerissa Mendoza, Thomas Holcomb, Ralph H. Schwall, Monica Kong-Beltran, Jiping Zha, Wenjing Zhu
Publikováno v:
Cancer Research. 66:283-289
Activating mutations in receptor tyrosine kinases play a critical role in oncogenesis. Despite evidence that Met kinase is deregulated in human cancer, the role of activating mutations in cancers other than renal papillary carcinoma has not been well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6793415ec0f0d7ee6e992b5d5000e8
https://doi.org/10.1158/0008-5472.can-05-2749
https://doi.org/10.1158/0008-5472.can-05-2749
Autor:
Nerissa Mendoza, Shirley Zhu, Amer M. Mirza, Ira D. Goldfine, Betty A. Maddux, Sandra Vanegas, Masahisa Handa
Publikováno v:
Obesity (Silver Spring, Md.). 21(2)
Objective: Interleukin-1β (IL-1β) has recently been implicated as a major cytokine that is involved in the pancreatic islet inflammation of type 2 diabetes mellitus. This inflammation impairs insulin secretion by inducing beta-cell apoptosis. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f603188c71121f4043b091d4d82eee9c
https://pubmed.ncbi.nlm.nih.gov/23401297
https://pubmed.ncbi.nlm.nih.gov/23401297
Autor:
Nerissa, Mendoza, Sharon, Fong, Jim, Marsters, Hartmut, Koeppen, Ralph, Schwall, Dineli, Wickramasinghe
Publikováno v:
Cancer research. 63(5)
A central function of the tumor suppressor retinoblastoma (Rb) is its ability to repress E2F transcriptional activity. Many cancers harbor inactivated Rb and consequently deregulated E2F. RXL peptides inhibit E2F recruitment and phosphorylation by CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8b65b60d171dd64f3bf40828933c38b
https://pubmed.ncbi.nlm.nih.gov/12615717
https://pubmed.ncbi.nlm.nih.gov/12615717
Publikováno v:
The Journal of biological chemistry. 277(49)
Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase c-Met, is composed of an alpha-chain containing four Kringle domains (K1-K4) and a serine protease domain-like beta-chain. Receptor activation by HGF is contingent upon prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3626d1bf91228144c7d2dd99d3265b
https://pubmed.ncbi.nlm.nih.gov/12372819
https://pubmed.ncbi.nlm.nih.gov/12372819
Publikováno v:
Cancer Research. 74:LB-151
TGFβ can play an important role in tumor progression. Whether expressed by the tumor, or the tumor microenvironment, it has a profound impact on not only the tumor itself but also the host immune system. There are three isoforms of TGFβ: TGFβ1, TG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e3e78139faad890f2bbffcd542beee9
https://doi.org/10.1158/1538-7445.am2014-lb-151
https://doi.org/10.1158/1538-7445.am2014-lb-151