Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nerina, Dodic"'
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
Autor:
David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Abstract Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have use
Externí odkaz:
https://doaj.org/article/73075a476ae1421891a994ecbcb35e20
Autor:
Nerina Dodic, Nicolas Ancellin, Morgane Bordessoules, Anne Bouillot, Nathan Butin, Cedric Charrier, Marie-Helene Fouchet, Alain Laroze, Anne-Pascale Luzy, Alexandre Moquette, Julia Pilot, Guillaume Serin, Jean-François Mirjolet, Fabrice Viviani, Christophe Parsy
Publikováno v:
Cancer Research. 82:1398-1398
Small molecule macrocyclic kinase inhibitors have attracted significant attention in drug discovery over the past years with drugs approval such as lorlatinib demonstrating the clinical relevance of this approach. We developed our expertise to furthe
Autor:
Martin Rüdiger, Chun-wa Chung, Jonathan P. Hutchinson, Christopher C. Arico-Muendel, Svetlana L. Belyanskaya, Allison Olszewski, Nerina Dodic, Duncan S. Holmes, Anthony Dossang, Andrew C. Pearce, Alistair M. Jagger, Steve Wilson, Adriana Ordóñez, David A. Lomas, Toral Jakhria, Iain Uings, Hitesh Dave, Zhengrong Zhu, Stefan J. Marciniak, Alexis Denis, Lionel Trottet, Kathrine J. Smith, Murray J. B. Brown, Imran Haq, James A. Irving, Steve Skinner, Margaret Neu, Diana Klimaszewska, Peter Eddershaw, Riccardo Ronzoni, James E. Rowedder, Andrew Brewster, John Liddle, Emilie Jigorel, Jeffrey A. Messer, Ken Lind, Rebecca Terry
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA
Autor:
John, Liddle, Andrew C, Pearce, Christopher, Arico-Muendel, Svetlana, Belyanskaya, Andrew, Brewster, Murray, Brown, Chun-Wa, Chung, Alexis, Denis, Nerina, Dodic, Anthony, Dossang, Peter, Eddershaw, Diana, Klimaszewska, Imran, Haq, Duncan S, Holmes, Alistair, Jagger, Toral, Jakhria, Emilie, Jigorel, Ken, Lind, Jeff, Messer, Margaret, Neu, Allison, Olszewski, Riccardo, Ronzoni, James, Rowedder, Martin, Rüdiger, Steve, Skinner, Kathrine J, Smith, Lionel, Trottet, Iain, Uings, Zhengrong, Zhu, James A, Irving, David A, Lomas
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Autor:
Stefan J. Marciniak, Martin Rüdiger, Hitesh Dave, Jonathan P. Hutchinson, Margaret Neu, Anthony Dossang, Riccardo Ronzoni, Lionel Trottet, Adriana Ordóñez, Chun-wa Chung, Christopher C. Arico-Muendel, Alexis Denis, Allison Olszewski, Andrew C. Pearce, Ken Lind, Peter Eddershaw, Andrew Brewster, Rebecca Terry, Jeffrey A. Messer, John Liddle, Iain Uings, Emilie Jigorel, James A. Irving, Nerina Dodic, Zhengrong Zhu, Kathrine J. Smith, Duncan S. Holmes, Steve Skinner, Steve Wilson, David A. Lomas, Diana Klimaszewska, James E. Rowedder, Murray J. B. Brown, Alistair M. Jagger, Toral Jakhria, Imran Haq, Svetlana L. Belyanskaya
Severe α1-antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1-antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA-encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5dc4b6dd1fbecffcf82db1f278226c
https://doi.org/10.1101/2020.07.26.217661
https://doi.org/10.1101/2020.07.26.217661
Autor:
Lionel Trottet, Martin Rüdiger, Anthony Dossang, Alexis Denis, David A. Lomas, James A. Irving, Andrew C. Pearce, Andrew Brewster, John Liddle, Zhengrong Zhu, Peter Eddershaw, James E. Rowedder, Kathrine J. Smith, Chun-wa Chung, Ken Lind, Christopher C. Arico-Muendel, Jeffrey A. Messer, Allison Olszewski, Diana Klimaszewska, Murray J. B. Brown, Nerina Dodic, Duncan S. Holmes, Imran Haq, Alistair M. Jagger, Toral Jakhria, Steve Skinner, Margaret Neu, Riccardo Ronzoni, Emilie Jigorel, Iain Uings, Svetlana L. Belyanskaya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:127973
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α1-antitrypsin were iden
Autor:
Colin J. Suckling, Claus Spitzfaden, Andrew N. Hobbs, Craig Jamieson, Peter Francis, Robert J. Young, Ian Churcher, Sophie M. Bertrand, Ryan P. Bingham, Sarah E. Smith, Donald O. Somers, Nicolas Ancellin, Nerina Dodic, Paul S. Carter, Chun-wa Chung, Charlène Fournier, Jennifer A. Borthwick, Stephen D. Pickett
Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment screening, are described. This was carried out using a combination of STD-NMR, thermal melt (Tm), and biochemical assays to identify compounds that bound t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019a009ff86efad911c0ace056f53ba5
https://strathprints.strath.ac.uk/55944/1/Borthwick_etal_JMC_2016_structurally_diverse_mitochondrial_branched_chain_aminotransferase_BCATm_leads_with_varying_binding_modes_identified_by_fragment_screening.pdf
https://strathprints.strath.ac.uk/55944/1/Borthwick_etal_JMC_2016_structurally_diverse_mitochondrial_branched_chain_aminotransferase_BCATm_leads_with_varying_binding_modes_identified_by_fragment_screening.pdf
Autor:
Svetlana L. Belyanskaya, Chun-wa Chung, Eric Humphries, Christopher S. Kollmann, Nicolas Ancellin, Christopher C. Arico-Muendel, Hongfeng Deng, Ryan P. Bingham, Van Loc Nguyen, Jeffrey A. Messer, Yun Ding, Emily Blazensky, Arthur Beljean, Anne-Benedicte Boullay, Sarah E. Smith, Jingye Zhou, Edwige Nicodeme, Jing Chai, Flora S. Sundersingh, Clare I. Hobbs, Alain Claude-Marie Daugan, Myriam Ajakane, Donald O. Somers, Nerina Dodic, Kenny Herry, Paul S. Carter, Eric Boursier
To identify BCATm inhibitors suitable for in vivo study, Encoded Library Technology (ELT) was used to affinity screen a 117 million member benzimidazole based DNA encoded library, which identified an inhibitor series with both biochemical and cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d2b0e96f6386d1d5d0d6f742324e42
https://europepmc.org/articles/PMC4834658/
https://europepmc.org/articles/PMC4834658/
Autor:
Hervé Coste, Marie-Hélène Fouchet, Frédéric Donche, Sylvie Demaria Magny, Florent Potvain, M Walker, Marc Issandou, Nerina Dodic, Anne-Benedicte Boullay, Anne Marie Jeanne Bouillot, Christophe Junot, Christelle Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6218-6232
We describe the discovery of novel potent inhibitors of 2,3-oxidosqualene:lanosterol cyclase inhibitors (OSCi) from a focused pharmacophore-based screen. Optimization of the most tractable hits gave a series of compounds showing inhibition of cholest
Autor:
Ian Churcher, Sarah E. Smith, Ryan P. Bingham, Clare I. Hobbs, Donald O. Somers, Eric Boursier, Chun Wa Chung, Charlène Fournier, Yoshiaki Washio, Peter Francis, Claus Spitzfaden, Iain H. Reid, Stephen D. Pickett, Sophie M. Bertrand, Graham L. Simpson, Andrew N. Hobbs, Klára Valkó, Laura A. Gummer, Robert J. Young, Nicolas Ancellin, Craig Jamieson, Colin J. Suckling, Anne Bénédicte Boullay, Lisa A. Sloan, Kenny Herry, Paul S. Carter, Nerina Dodic, Paul Homes, Edwige Nicodeme, Jennifer A. Borthwick, Benjamin Beaufils, Marie Helene Fouchet
Publikováno v:
Journal of medicinal chemistry. 58(18)
The hybridization of hits, identified by complementary fragment and high throughput screens, enabled the discovery of the first series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a 2-benzylamino-pyrazolo[1,5