Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nergiz Dogan"'
Autor:
Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Molecular heterogeneity of acute myeloid leukaemia (AML) across patients is a major challenge for prognosis and therapy. Here, the authors show that NPM1 mutated AML is a heterogeneous class, consisting of two subtypes which exhibit distinct molecula
Externí odkaz:
https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a2551
Autor:
Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level
Externí odkaz:
https://doaj.org/article/130018a3112a40a29ff505012c3352a4
Autor:
Corey Nislow, Sören Lehmann, Alex Murison, Gary D. Bader, Mark Gower, Liran I. Shlush, Benjamin Haibe-Kains, Nergiz Dogan-Artun, Rose Hurren, John E. Dick, Veronique Voisin, Cynthia J. Guidos, Sisira Kadambat Nair, Seyed Ali Madani Tonekaboni, Mathieu Lupien, Emily Heath, Mark D. Minden, Aaron D. Schimmer, Laura García-Prat, Arvind Singh Mer, Mattias Rantalainen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World Health Organization classification. However, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a6afccd7c22d8d47d3afb6baf7044f
https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a2551
https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a2551
Autor:
Qin Wu, David Y. Nie, Wail Ba-alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E. Ciamponi, Jocelyn Chen, Shili Duan, Yudao Shen, Jing Liu, Sajid A. Marhon, Parinaz Mehdipour, Magdalena M. Szewczyk, Nergiz Dogan-Artun, WenJun Chen, Lan Xin Zhang, Genevieve Deblois, Panagiotis Prinos, Katlin B. Massirer, Dalia Barsyte-Lovejoy, Jian Jin, Daniel D. De Carvalho, Benjamin Haibe-Kains, XiaoJia Wang, David W. Cescon, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature chemical biology. 18(8)
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I protein arginine methyltransferases (PRMTs), which has antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e053a6a43b2d55b8a9ab0d5b48f865fb
https://pubmed.ncbi.nlm.nih.gov/35578033
https://pubmed.ncbi.nlm.nih.gov/35578033
Autor:
Hassan Mahmoud, Yan Nie, Benjamin Haibe-Kains, Mathieu Lupien, Jillian Haight, Susan J. Done, Peter B. Dirks, Evelyne Lima-Fernandes, Bradly G. Wouters, Nergiz Dogan-Artun, David W. Cescon, Wenjun Chen, Jennifer Cruickshank, Wail Ba-alawi, Trevor D. McKee, Stanley Zhou, Michelle Kushida, Seyed Ali Madani Tonekaboni, Shili Duan, Ravi N. Vellanki, Cheryl H. Arrowsmith, Panagiotis Prinos, Geneviève Deblois, Morag Park, Qin Wu, Lan Xin Zhang, Hellen Kuasne, Anne-Marie Fortier, Sarina Cameron
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da066793c04fdd2b3ec5986a039b51
https://doi.org/10.1038/s41467-020-18020-8
https://doi.org/10.1038/s41467-020-18020-8
Autor:
Mathieu Lupien, Shashirekha Shetty, Qiulian Wu, Megan S. Piazza, Xiuxing Wang, Stephane Angers, Brian P. Rubin, Stephen C. Mack, Jeremy N. Rich, Ryan C. Gimple, Zachary J Faber, Nergiz Dogan-Artun, Peter B. Dirks, Richard C Sallari, Kevin C. Allan, Andrew R. Morton, Graham MacLeod, Cynthia F. Bartels, Peter C. Scacheri
Publikováno v:
Cell
Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplified oncogenes across five cancer types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8b917dabe6f566ee78dae40b5c9149
https://europepmc.org/articles/PMC7241652/
https://europepmc.org/articles/PMC7241652/
Autor:
David W. Cescon, Susan J. Done, Ravi N. Vellanki, Nergiz Dogan-Artun, Sarina Cameron, Wenjun Chen, Wail Ba-alawi, Qin Wu, Benjamin Haibe-Kains, Stanley Zhou, Mathieu Lupien, Shili Duan, Morag Park, Hellen Kuasne, Hassan Mahmoud, Geneviève Deblois, Cheryl H. Arrowsmith, Jennifer Cruickshank, Trevor D. McKee, Seyed Ali Madani Tonekaboni, Evelyne Lima-Fernandes, Anne-Marie Fortier, Jillian Haight
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f09514f499437016415264caafd72f
https://doi.org/10.1101/764944
https://doi.org/10.1101/764944
Publikováno v:
Food Chemistry. 111:824-829
Crude exo-polygalacturonase enzyme (produced by Aspergillus sojae), significant for industrial processes, was characterized with respect to its biochemical and thermal properties. The optimum pH and temperature for maximum crude exo-polygalacturonase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef912f9498d651c2195410c261af22e
https://doi.org/10.1016/j.foodchem.2008.04.056
https://doi.org/10.1016/j.foodchem.2008.04.056
Autor:
Nergiz Dogan, Canan Tari
Publikováno v:
Biochemical Engineering Journal. 39:43-50
Exo-polygalacturonase enzyme produced by Aspergillus sojae ATCC 20235 was purified using three-phase partitioning (TPP), an emerging bio-separation technique where a single step as compared to the classical multi-step purification was used. Using thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd40874722054a5451dcf322622572af
https://doi.org/10.1016/j.bej.2007.08.008
https://doi.org/10.1016/j.bej.2007.08.008
Autor:
Ross C. Hardison, Yong Cheng, Cheryl A. Keller, Maria Long, Len A. Pennacchio, Aaron J. Stonestrom, Axel Visel, Weisheng Wu, Christapher S. Morrissey, Deepti Jain, Nergiz Dogan, Gerd A. Blobel, Mitchell J. Weiss, Kuan Bei Chen
Publikováno v:
Epigenetics & Chromatin
Background Regulated gene expression controls organismal development, and variation in regulatory patterns has been implicated in complex traits. Thus accurate prediction of enhancers is important for further understanding of these processes. Genome-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155126167949421f06f01eea1de1fa8a
https://pubmed.ncbi.nlm.nih.gov/25984238
https://pubmed.ncbi.nlm.nih.gov/25984238