Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nerea Ferreiròs"'
Autor:
Jörn Lötsch, Khayal Gasimli, Sebastian Malkusch, Lisa Hahnefeld, Carlo Angioni, Yannick Schreiber, Sandra Trautmann, Saskia Wedel, Dominique Thomas, Nerea Ferreiros Bouzas, Christian H Brandts, Benjamin Schnappauf, Christine Solbach, Gerd Geisslinger, Marco Sisignano
Publikováno v:
eLife, Vol 13 (2024)
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify th
Externí odkaz:
https://doaj.org/article/2f70ecc6b60c49e0aa4c7ee6c353f55a
Autor:
Tamara Rothenburger, Dominique Thomas, Yannick Schreiber, Paul R. Wratil, Tamara Pflantz, Kirsten Knecht, Katie Digianantonio, Joshua Temple, Constanze Schneider, Hanna-Mari Baldauf, Katie-May McLaughlin, Florian Rothweiler, Berna Bilen, Samira Farmand, Denisa Bojkova, Rui Costa, Nerea Ferreirós, Gerd Geisslinger, Thomas Oellerich, Yong Xiong, Oliver T. Keppler, Mark N. Wass, Martin Michaelis, Jindrich Cinatl
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMH
Externí odkaz:
https://doaj.org/article/d96327060ccf4b409f6c8453b5c904c2
Autor:
Thomas Oellerich, Constanze Schneider, Dominique Thomas, Kirsten M. Knecht, Olga Buzovetsky, Lars Kaderali, Christoph Schliemann, Hanibal Bohnenberger, Linus Angenendt, Wolfgang Hartmann, Eva Wardelmann, Tamara Rothenburger, Sebastian Mohr, Sebastian Scheich, Federico Comoglio, Anne Wilke, Philipp Ströbel, Hubert Serve, Martin Michaelis, Nerea Ferreirós, Gerd Geisslinger, Yong Xiong, Oliver T. Keppler, Jindrich Cinatl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
In acute myeloid leukemia, hypomethylating agents decitabine and azacytidine are used interchangeably. Here, the authors show that the major metabolite of decitabine, but not azacytidine, is subject to SAMHD1 inactivation, highlighting SAMHD1 as a po
Externí odkaz:
https://doaj.org/article/95a48b4cc3c74d05b739c67d702815e2
Autor:
Gergely Imre, Verena Krähling, Madeleine Eichler, Sandra Trautmann, Nerea Ferreirós, M. Javad Aman, Fatah Kashanchi, Krishnaraj Rajalingam, Stefan Pöhlmann, Stephan Becker, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102266- (2021)
Summary: Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths. EBOV glycoprotein (EBOV-GP) is the only viral surface protein and is responsible for
Externí odkaz:
https://doaj.org/article/a4d3b8fd63584eefb7be8371826ef0f5
Autor:
Lisa Kornstädt, Sandra Pierre, Andreas Weigert, Stefanie Ebersberger, Tim J. Schäufele, Anja Kolbinger, Tobias Schmid, Jennifer Cohnen, Dominique Thomas, Nerea Ferreirós, Bernhard Brüne, Ingo Ebersberger, Klaus Scholich
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Next to their role in IgE-mediated allergic diseases and in promoting inflammation, mast cells also have antiinflammatory functions. They release pro- as well as antiinflammatory mediators, depending on the biological setting. Here we aimed to better
Externí odkaz:
https://doaj.org/article/7e735f31a36b485bbd14ab87216dc27f
Autor:
Christian Fork, Andrea E. Vasconez, Patrick Janetzko, Carlo Angioni, Yannick Schreiber, Nerea Ferreirós, Gerd Geisslinger, Matthias S. Leisegang, Dieter Steinhilber, Ralf P. Brandes
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 386-392 (2017)
Nonsteroidal anti-inflammatory drugs are the most widely used medicine to treat pain and inflammation, and to inhibit platelet function. Understanding the expression regulation of enzymes of the prostanoid pathway is of great medical relevance. Histo
Externí odkaz:
https://doaj.org/article/9bf37fdf2b6e410a8cb48d901a0dbe37
Autor:
Sebastian Luger, Annette Schwebler, Rajkumar Vutukuri, Nerea Ferreiros Bouzas, Sandra Labocha, Yannick Schreiber, Robert Brunkhorst, Helmuth Steinmetz, Josef Pfeilschifter, Waltraud Pfeilschifter
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 11 (2018)
Background: Sphingolipids are versatile signaling molecules derived from membrane lipids of eukaryotic cells. Ceramides regulate cellular processes such as proliferation, differentiation and apoptosis and are involved in cellular stress responses. Ex
Externí odkaz:
https://doaj.org/article/95ad1416b8f548539b5a84dda46762ab
Autor:
Johannes Vogt, Jenq‐Wei Yang, Arian Mobascher, Jin Cheng, Yunbo Li, Xingfeng Liu, Jan Baumgart, Carine Thalman, Sergei Kirischuk, Petr Unichenko, Guilherme Horta, Konstantin Radyushkin, Albrecht Stroh, Sebastian Richers, Nassim Sahragard, Ute Distler, Stefan Tenzer, Lianyong Qiao, Klaus Lieb, Oliver Tüscher, Harald Binder, Nerea Ferreiros, Irmgard Tegeder, Andrew J Morris, Sergiu Gropa, Peter Nürnberg, Mohammad R Toliat, Georg Winterer, Heiko J Luhmann, Jisen Huai, Robert Nitsch
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 1, Pp 25-38 (2015)
Abstract Loss of plasticity‐related gene 1 (PRG‐1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks. A recently reported
Externí odkaz:
https://doaj.org/article/d9725db74d88432db8fdfb78fb4c4402
Autor:
Katja Schmitz, Natasja de Bruin, Philipp Bishay, Julia Männich, Annett Häussler, Christine Altmann, Nerea Ferreirós, Jörn Lötsch, Alfred Ultsch, Michael J Parnham, Gerd Geisslinger, Irmgard Tegeder
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 11, Pp 1398-1422 (2014)
Abstract R‐flurbiprofen is the non‐cyclooxygenase inhibiting R‐enantiomer of the non‐steroidal anti‐inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease. Because of its anti‐inflammatory, endocannabinoid
Externí odkaz:
https://doaj.org/article/21bfba4003aa438daa7566e0f3f1b1e4
Autor:
Julia Homann, Jing Suo, Mike Schmidt, Natasja de Bruin, Klaus Scholich, Gerd Geisslinger, Nerea Ferreirós
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143141 (2015)
The activation and infiltration of polymorphonuclear neutrophils (PMN) are critical key steps in inflammation. PMN-mediated inflammation is limited by anti-inflammatory and pro-resolving mechanisms, including specialized pro-resolving lipid mediators
Externí odkaz:
https://doaj.org/article/5059d766afb144c5abe279618083501c