Targets, Mechanisms and Cytotoxicity of Half-Sandwich Ir(III) Complexes Are Modulated by Structural Modifications on the Benzazole Ancillary Ligand

Autor: M. Isabel Acuña, Ana R. Rubio, Marta Martínez-Alonso, Natalia Busto, Ana María Rodríguez, Nerea Davila-Ferreira, Carl Smythe, Gustavo Espino, Begoña García, Fernando Domínguez

Publikováno v: Cancers; Volume 15; Issue 1; Pages: 107

Cancers are driven by multiple genetic mutations but evolve to evade treatments targeting specific mutations. Nonetheless, cancers cannot evade a treatment that targets mitochondria, which are essential for tumor progression. Iridium complexes have s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1ab896c8e87e616dcffcd33111f428

New half-sandwich ruthenium(II) complexes as proteosynthesis inhibitors in cancer cells

Autor: Enrique Ortega, Fernando Domínguez, Nerea Davila-Ferreira, Delia Bautista, José Ruiz, Vanesa Porto, Viktor Brabec, M. Dolores Santana, Francisco J. Ballester, Hana Kostrhunova

Publikováno v: DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname

Half-sandwich ruthenium(ii) complexes [(η6-p-cymene)Ru(C^N)-(X)]0/+ (X = Cl, py or 4-NMe2-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec24b722993556818a62af563623173
http://hdl.handle.net/10201/101952