Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nerea Cuesta-Gomez"'
Autor:
Joshua Hefler, Rena Pawlick, Braulio A. Marfil-Garza, Aducio Thiesen, Nerea Cuesta-Gomez, Sanaz Hatami, Darren H. Freed, Constantine Karvellas, David L. Bigam, A.M. James Shapiro
Publikováno v:
Liver Research, Vol 8, Iss 1, Pp 46-53 (2024)
Background and aim: The liver is susceptible to ischemia-reperfusion injury (IRI) during hepatic surgery, when the vessels are compressed to control bleeding, or liver transplantation, when there is an obligate period of ischemia. The hallmark of IRI
Externí odkaz:
https://doaj.org/article/693f51dceabc49638b6ca0e12260321d
Autor:
Lauren P. Westhaver, Sarah Nersesian, Riley J. Arseneau, Joshua Hefler, Breanna K.V. Hargreaves, Alexander Edgar, Yara Azizieh, Nerea Cuesta-Gomez, Dayne L. Izquierdo, A.M. James Shapiro, Boris L. Gala-Lopez, Jeanette E. Boudreau
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27122- (2024)
Ex vivo normothermic machine perfusion (NMP) preserves donor organs and permits real-time assessment of allograft health, but the most effective indicators of graft viability are uncertain. Mitochondrial DNA (mtDNA), released consequent to traumatic
Externí odkaz:
https://doaj.org/article/48e0c9824b6843ca8c66c51224be8bf1
Autor:
Nerea Cuesta-Gomez, Kevin Verhoeff, Nidheesh Dadheech, Tiffany Dang, Ila Tewari Jasra, Mario Bermudez de Leon, Rena Pawlick, Braulio Marfil-Garza, Perveen Anwar, Haide Razavy, Patricio Adrián Zapata-Morin, Glen Jickling, Aducio Thiesen, Doug O’Gorman, Michael S. Kallos, A. M. James Shapiro
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and cardiomyocytes. However, translation of these regenerative ce
Externí odkaz:
https://doaj.org/article/871ddb8a83944edb9407894503394516
Autor:
Ila Tewari Jasra, Nerea Cuesta-Gomez, Kevin Verhoeff, Braulio A. Marfil-Garza, Nidheesh Dadheech, A. M. James Shapiro
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Mitochondria are the powerhouse of the cell and dynamically control fundamental biological processes including cell reprogramming, pluripotency, and lineage specification. Although remarkable progress in induced pluripotent stem cell (iPSC)-derived c
Externí odkaz:
https://doaj.org/article/b2e9252fe80a4403ba987809445a0117
Autor:
Purushothaman Kuppan, Jordan Wong, Sandra Kelly, Jiaxin Lin, Jessica Worton, Chelsea Castro, Joy Paramor, Karen Seeberger, Nerea Cuesta-Gomez, Colin C. Anderson, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2201 (2023)
One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) micropart
Externí odkaz:
https://doaj.org/article/16b9bbccce744ae580602897ab1613e8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10132 (2023)
Mesenchymal stromal cells (MSC) show promise as cellular therapeutics. Psoriasis is a chronic inflammatory disease affecting the skin and the joints. Injury, trauma, infection and medications can trigger psoriasis by disrupting epidermal keratinocyte
Externí odkaz:
https://doaj.org/article/9f236413961349109b7531b1a869fc8b
Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for the treatment of inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory and regenerative potentials. MSCs can be sourced f
Externí odkaz:
https://doaj.org/article/a888e7ce3d414a8bb7cc212c7879a0e6
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10132
Mesenchymal stromal cells (MSC) show promise as cellular therapeutics. Psoriasis is a chronic inflammatory disease affecting the skin and the joints. Injury, trauma, infection and medications can trigger psoriasis by disrupting epidermal keratinocyte
Autor:
Kevin Verhoeff, Braulio A Marfil-Garza, Zofia Czarnecka, Nerea Cuesta-Gomez, Ila Tewari Jasra, Nidheesh Dadheech, Peter A Senior, A M James Shapiro
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Historically, only patients with brittle diabetes or severe recurrent hypoglycemia have been considered for islet transplantation (ITx). This population has been selected to optimize the risk-benefit profile considering risks of long-term immunosuppr
Autor:
Nerea Cuesta-Gomez, Kevin Verhoeff, Nidheesh Dadheech, Rena Pawlick, Braulio Marfil-Garza, Haide Razavy, A.M. James Shapiro
SummaryGeneration of pure pancreatic progenitor cells (PPs) is critical for clinical translation of stem cell derived islets. Herein, we performed PP differentiation with and without AKT/P70 inhibitor AT7867 and characterized the resulting cells at p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::348a8c6e596bc7fec65c679c2ca8fb9e
https://doi.org/10.1101/2023.05.11.538780
https://doi.org/10.1101/2023.05.11.538780