Application of a dual mechanistic approach to support bilastine dose selection for older adults

Autor: Chaejin Kim, Valentina Lo Re, Monica Rodriguez, John C. Lukas, Nerea Leal, Cristina Campo, Aintzane García‐Bea, Elena Suarez, Stephan Schmidt, Valvanera Vozmediano

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1006-1017 (2021)

Abstract The objective of this study was to evaluate bilastine dosing recommendations in older adults and overcome the limitation of insufficient data from phase I studies in this underrepresented population. This was achieved by integrating bilastin

Externí odkaz: https://doaj.org/article/2409e3bfd14a4f6db9eeca7e4cc482ea

Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions

Autor: M. G. M. de Sain-van der Velden, T.J. de Koning, C. Oussoren, Nerea Leal, Cornelus F. van Nostrum, Monica Rodriguez, Feilong Sun, Thierry K. Slot, Thijs Rooimans, Wim E. Hennink, Peter M. van Hasselt, G.E.P.J. Janssens, Roderick H. J. Houwen, M. van der Ham, Herman Vromans, Tanca Minderhoud

Publikováno v: Gastroenterology, 161(3), 1056. W.B. Saunders Ltd
Lipophilic Drug Delivery Despite Cholestasis Study Group 2021, ' Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions ', Gastroenterology, vol. 161, no. 3, pp. 1056-1059.e5 . https://doi.org/10.1053/j.gastro.2021.05.056

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c9671ac00c41cd32e4445d1ca784d3
https://hdl.handle.net/1874/412888

Tacrolimus pharmacokinetics in the early post-liver transplantation period and clinical applicability via Bayesian prediction

Autor: Nerea Leal, Andrés Valdivieso, Itziar Oteo, Mikel Gastaca, Jorge Ortiz de Urbina, Elena Suarez, Rosario Calvo, John C. Lukas

Publikováno v: European Journal of Clinical Pharmacology. 69:65-74

To define and validate a pharmacokinetic (PK) model for tacrolimus (TAC) that includes patient pathophysiology and has clinical applicability in the first 2 weeks post-liver transplantation (PLT). Routine monitoring records [dose, trough levels (Cmin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8740f1af28cd84d56af85c9599c5e70
https://doi.org/10.1007/s00228-012-1300-z

Pathophysiological idiosyncrasies and pharmacokinetic realities may interfere with tacrolimus dose titration in liver transplantation

Autor: Mikel Gastaca, Itziar Oteo, John C. Lukas, Andrés Valdivieso, Jorge Ortiz de Urbina, Rosario Calvo, Elena Suarez, Nerea Leal

Publikováno v: European Journal of Clinical Pharmacology. 67:671-679

To explore the main factors that make it difficult to empirically monitor tacrolimus (TAC) in the early period post-liver transplantation (LTx), with a specific focus on those aspects related to patient idiosyncrasy and clinical status as well as to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8db4bb774ca9896d149ccb20f291e5
https://doi.org/10.1007/s00228-011-0998-3

Altered dose-to-effect of propofol due to pharmacokinetics in rats with experimental diabetes mellitus

Autor: Nerea Leal, L. De La Fuente, F Z Agrad, John C. Lukas, Elena Suarez, Rosario Calvo

Publikováno v: Journal of Pharmacy and Pharmacology. 57:317-325

Pathology related alterations in the pharmacokinetics or the pharmacodynamics of propofol could contribute to the observed large variability in the hypnotic dose. We have tested the influence of diabetes mellitus on the induction dose and the pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b8f304ea80912b8291e8db85fe44ef
https://doi.org/10.1211/0022357055498