Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

Autor: Speca, DJ, Ogata, G, Mandikian, D, Bishop, HI, Wiler, SW, Eum, K, Wenzel, HJ, Doisy, ET, Matt, L, Campi, KL, Golub, MS, Nerbonne, JM, Hell, JW, Trainor, BC, Sack, JT, Schwartzkroin, PA, Trimmer, JS

Publikováno v: Genes, brain, and behavior, vol 13, iss 4
Speca, DJ; Ogata, G; Mandikian, D; Bishop, HI; Wiler, SW; Eum, K; et al.(2014). Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes, Brain and Behavior, 13(4), 394-408. doi: 10.1111/gbb.12120. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7j75t5d2

The Kv2.1 delayed rectifier potassium channel exhibits high-level expression in both principal and inhibitory neurons throughout the central nervous system, including prominent expression in hippocampal neurons. Studies of in vitro preparations sugge

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https://escholarship.org/uc/item/7j75t5d2

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Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.

Autor: Walker EC; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Program in Immunology, Division of Biological and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA., Javati S; Infection and Immunity Unit, Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Todd EM; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Matlam JP; Infection and Immunity Unit, Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Lin X; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Bryant M; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Krone E; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Ramani R; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Chandra P; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Green TP; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Anaya EP; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Zhou JY; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA., Alexander KA; Department of Pediatrics, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, MO, USA., Tong RS; Department of Pediatrics, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, MO, USA., Yuasi L; Infection and Immunity Unit, Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Boluarte S; Department. of Pediatrics, Division of Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Yang F; Department. of Pediatrics, Division of Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Greenberg L; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Nerbonne JM; Departments of Developmental Biology and Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA., Greenberg MJ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Clemens RA; Department. of Pediatrics, Division of Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Philips JA; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Wilson LD; Division of Comparative Medicine, Research Animal Diagnostic Laboratory, Washington University School of Medicine, St. Louis, MO, USA., Halabi CM; Department of Pediatrics, Division of Nephrology and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., DeBosch BJ; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology & Nutrition, Indiana University School of Medicine, Indianapolis, IN, USA., Blyth CC; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute and School of Medicine, University of Western Australia, Nedlands, Western Australia, Australia.; Department of Infectious Diseases, Perth Children's Hospital, Nedlands, Western Australia, Australia.; Department of Microbiology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Western Australia, Australia., Druley TE; Department of Pediatrics, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, MO, USA., Kazura JW; Center for Global Health & Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Pomat WS; Infection and Immunity Unit, Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.; Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute and School of Medicine, University of Western Australia, Nedlands, Western Australia, Australia., Morley SC; Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA. morleys@wustl.edu.; Program in Immunology, Division of Biological and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA. morleys@wustl.edu.; Dept. of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. morleys@wustl.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

Loss of Intracellular Fibroblast Growth Factor 14 (iFGF14) Increases the Excitability of Mature Hippocampal and Cortical Pyramidal Neurons.

Autor: Ransdell JL, Carrasquillo Y, Bosch MK, Mellor RL, Ornitz DM, Nerbonne JM

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 04. Date of Electronic Publication: 2024 May 04.

Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse.

Autor: Lesage A; CNRS, INSERM, L'institut du Thorax , Nantes Université, Nantes, France., Lorenzini M; CNRS, INSERM, L'institut du Thorax , Nantes Université, Nantes, France., Burel S; CNRS, INSERM, L'institut du Thorax , Nantes Université, Nantes, France., Sarlandie M; CNRS, INSERM, L'institut du Thorax , Nantes Université, Nantes, France., Bibault F; CNRS, INSERM, L'institut du Thorax , Nantes Université, Nantes, France., Lindskog C; Department of Immunology, Genetics and Pathology, Cancer Precision Medicine, Uppsala University, Uppsala, Sweden., Maloney D; Bioinformatics Solutions Inc. , Waterloo, ON, Canada., Silva JR; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Townsend RR; Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, MO, USA.; Department of Medicine, Washington University Medical School, St. Louis, MO, USA., Nerbonne JM; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.; Department of Medicine, Washington University Medical School, St. Louis, MO, USA.; Department of Developmental Biology, Washington University Medical School, St. Louis, MO, USA., Marionneau C; CNRS, INSERM, L'institut du Thorax , Nantes Université, Nantes, France.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2023 Sep 04; Vol. 155 (9). Date of Electronic Publication: 2023 Jul 27.