Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Nephtali, Marina"'
Autor:
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial
Externí odkaz:
https://doaj.org/article/460633936e6841f2ab72308399796298
Autor:
Yichao Yu, Christopher Payne, Nephtali Marina, Alla Korsak, Paul Southern, Ana García‐Prieto, Isabel N. Christie, Rebecca R. Baker, Elizabeth M. C. Fisher, Jack A. Wells, Tammy L. Kalber, Quentin A. Pankhurst, Alexander V. Gourine, Mark F. Lythgoe
Publikováno v:
Advanced Science, Vol 9, Iss 6, Pp n/a-n/a (2022)
Abstract Astrocytes play crucial and diverse roles in brain health and disease. The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existing
Externí odkaz:
https://doaj.org/article/3d7a471dc06340348c33afdea1613ef6
Autor:
Yasumasa Okada, Julian F. R. Paton, José López-Barneo, Richard J. A. Wilson, Nephtali Marina, Mieczyslaw Pokorski
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/3a592b4107d948678258180c45b61263
Autor:
Marie K. Holt, Daniel R. Cook, Daniel I. Brierley, James E. Richards, Frank Reimann, Alexander V. Gourine, Nephtali Marina, Stefan Trapp
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp 101024- (2020)
Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used as anti-diabetic drugs and are approved for obesity treatment. However, GLP-1RAs also affect heart rate (HR) and arterial blood pressure (ABP) in rodents and humans. Although th
Externí odkaz:
https://doaj.org/article/616c2c12738749848d745f5405c9d843
Autor:
Richard Ang, Nephtali Marina
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization i
Externí odkaz:
https://doaj.org/article/a0ead2d4f61641dabf25f2c79ab19937
Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity
Autor:
Shahriar Sheikhbahaei, Egor A. Turovsky, Patrick S. Hosford, Anna Hadjihambi, Shefeeq M. Theparambil, Beihui Liu, Nephtali Marina, Anja G. Teschemacher, Sergey Kasparov, Jeffrey C. Smith, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Circuits of the preBötzinger complex generate rhythms needed for breathing. Here, the authors provide evidence, using a combination of chemogenetic approaches and approaches to inhibit vesicular release, that astrocytes play a role in regulating res
Externí odkaz:
https://doaj.org/article/988bcc66305d4c098978f289c873fba5
Autor:
Asif Machhada, Stefan Trapp, Nephtali Marina, Robert C.M. Stephens, John Whittle, Mark F. Lythgoe, Sergey Kasparov, Gareth L. Ackland, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents,
Externí odkaz:
https://doaj.org/article/8cdfec5411aa48e89ca82cdf35f8635d
Autor:
Patrick S. Hosford, Natalia Ninkina, Vladimir L. Buchman, Jeffrey C. Smith, Nephtali Marina, Shahriar SheikhBahaei
Publikováno v:
Brain Sciences, Vol 10, Iss 9, p 583 (2020)
Synuclein (α, β, and γ) proteins are highly expressed in presynaptic terminals, and significant data exist supporting their role in regulating neurotransmitter release. Targeting the gene encoding α-synuclein is the basis of many animal models of
Externí odkaz:
https://doaj.org/article/6ce6a6308b2c44c1bcccb101ee746cff
Autor:
Shefeeq M. Theparambil, Noemí Esteras, Philip G. Haydon, Patrick S. Hosford, Anna Hadjihambi, Anja G. Teschemacher, Alla Korsak, Mark F. Lythgoe, Egor A. Turovsky, Nephtali Marina, Alexander V. Gourine, Yichao Yu, Alice Braga
Publikováno v:
The Journal of Neuroscience
Teschemacher, A G 2020, ' Mechanosensory signalling in astrocytes ', Journal of Neuroscience . https://doi.org/10.1523/JNEUROSCI.1249-20.2020
Teschemacher, A G 2020, ' Mechanosensory signalling in astrocytes ', Journal of Neuroscience . https://doi.org/10.1523/JNEUROSCI.1249-20.2020
Mechanosensitivity is a well-known feature of astrocytes, however, its underlying mechanisms and functional significance remain unclear. There is evidence that astrocytes are acutely sensitive to decreases in cerebral perfusion pressure and may funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048d950691e1f343934537a3549a6335
http://europepmc.org/articles/PMC7724146
http://europepmc.org/articles/PMC7724146
Autor:
Yichao Yu, Christopher Payne, Nephtali Marina, Alla Korsak, Paul Southern, Ana García‐Prieto, Isabel N. Christie, Rebecca R. Baker, Elizabeth M. C. Fisher, Jack A. Wells, Tammy L. Kalber, Quentin A. Pankhurst, Alexander V. Gourine, Mark F. Lythgoe
Publikováno v:
Adv Sci (Weinh)
Magnetomechanical Stimulation Magnetomechanical stimulation enables remote and selective control of brain cell activity without any need for genetic modification. Antibody‐functionalized magnetic particles are targeted to the mechanosensitive astro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab4a270213b9774dfa5b87a12f9e87
https://europepmc.org/articles/PMC8867192/
https://europepmc.org/articles/PMC8867192/
