Cancer predisposition syndromes as a risk factor for early second primary neoplasms after childhood cancer - A national cohort study

Autor: Nicolas Waespe, Marc Ansari, Jean-Pierre Bourquin, Maja Beck-Popovic, Fabiën N. Belle, Jochen Rössler, Shelagh Redmond, Ben D. Spycher, Nicolas von der Weid, Jeanette Greiner, Katrin Scheinemann, Claudia E. Kuehni, Christina Schindera, Freimut H. Schilling, Pierluigi Brazzola

Publikováno v: European journal of cancer, Vol. 145 (2021) pp. 71-80
Waespe, Nicolas; Belle, Fabiën N.; Redmond, Shelagh; Schindera, Christina; Spycher, Ben D.; Rössler, Jochen; Ansari, Marc; Kuehni, Claudia E. (2021). Cancer predisposition syndromes as a risk factor for early second primary neoplasms after childhood cancer-A national cohort study. European journal of cancer, 145, pp. 71-80. Elsevier 10.1016/j.ejca.2020.11.042

Background: Childhood cancer patients are at increased risk of second primary neoplasms (SPNs). We assessed incidence and risk factors for early SPNs with a focus on cancer predisposition syndromes (CPSs). Patients and methods: This cohort study used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacba93b3aead1ce124526b0cc6cbdda
https://doi.org/10.5167/uzh-213020

Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes

Autor: Anna Byrjalsen, René Mathiasen, Peder Skov Wehner, Nanna Moeller Barnkob, Kjeld Schmiegelow, David Scheie, Henrik Hasle, Lisa Lyngsie Hjalgrim, Ruta Tuckuviene, Mana M. Mehrjouy, Charlotte Kvist Lautrup, Karin Wadt, Adrian O. Laspiur, Thomas Hansen, Tina Elisabeth Olsen, Maria Rossing, Peter Wad Sackett, Pernille Axel Gregersen, Anne-Marie Gerdes, Ulrik Stoltze, Niels Tommerup, Ramneek Gupta, Rasmus L. Marvig

Publikováno v: Byrjalsen, A, Hansen, T V O, Stoltze, U K, Mehrjouy, M M, Barnkob, N M, Hjalgrim, L L, Mathiasen, R, Lautrup, C K, Gregersen, P A, Hasle, H, Wehner, P S, Tuckuviene, R, Sackett, P W, Laspiur, A O, Rossing, M, Marvig, R L, Tommerup, N, Olsen, T E, Scheie, D, Gupta, R, Gerdes, A M, Schmiegelow, K & Wadt, K 2020, ' Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high frequency of cancer prone syndromes ', PLOS Genetics, vol. 16, no. 12, e1009231 . https://doi.org/10.1371/JOURNAL.PGEN.1009231
Byrjalsen, A, Hansen, T, Stoltze, U, Mehrjouy, M, Barnkob, N, Hjalgrim, L, Mathiasen, R, Lautrup, C K, Gregersen, P, Hasle, H, Wehner, P, Tuckuviene, R, Sackett, P, Laspiu, A, Rossing, M, Marvig, R, Tommerup, N, Olsen, T, Scheie, D, Gupta, R, Gerdes, A-M, Schmiegelow, K & Wadt, K 2020, ' Nationwide Germline Whole Genome Sequencing of 198 Consecutive Pediatric Cancer Patients Reveals a High Incidence of Cancer Prone Syndromes ', Pediatric Blood & Cancer, vol. 67, no. Suppl. 4, 0719 / #1167, pp. S323 .
PLoS Genetics
Byrjalsen, A, Hansen, T V O, Stoltze, U K, Mehrjouy, M M, Barnkob, N M, Hjalgrim, L L, Mathiasen, R, Lautrup, C K, Gregersen, P A, Hasle, H, Wehner, P S, Tuckuviene, R, Sackett, P W, Laspiur, A O, Rossing, M, Marvig, R L, Tommerup, N, Olsen, T E, Scheie, D, Gupta, R, Gerdes, A M, Schmiegelow, K & Wadt, K 2020, ' Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes ', PLOS Genetics, vol. 16, no. 12, e1009231 . https://doi.org/10.1371/JOURNAL.PGEN.1009231
Byrjalsen, A, Hansen, T V O, Stoltze, U K, Mehrjouy, M M, Barnkob, N M, Hjalgrim, L L, Mathiasen, R, Lautrup, C K, Gregersen, P A, Hasle, H, Wehner, P S, Tuckuviene, R, Sackett, P W, Laspiur, A O, Rossing, M, Marvig, R L, Tommerup, N, Olsen, T E, Scheie, D, Gupta, R, Gerdes, A-M, Schmiegelow, K & Wadt, K 2020, ' Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high frequency of cancer prone syndromes ', PLOS Genetics, vol. 16, no. 12, e1009231 . https://doi.org/10.1371/journal.pgen.1009231
PLoS Genetics, Vol 16, Iss 12, p e1009231 (2020)
Byrjalsen, A, Hansen, T V O, Stoltze, U K, Mehrjouy, M M, Barnkob, N M, Hjalgrim, L L, Mathiasen, R, Lautrup, C K, Gregersen, P A, Hasle, H, Wehner, P S, Tuckuviene, R, Sackett, P W, Laspiur, A O, Rossing, M, Marvig, R L, Tommerup, N, Olsen, T E, Scheie, D, Gupta, R, Gerdes, A-M, Schmiegelow, K & Wadt, K 2020, ' Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes ', PLOS Genetics, vol. 16, no. 12, e1009231 . https://doi.org/10.1371/journal.pgen.1009231
Byrjalsen, A, Hansen, T, Stoltze, U, Mehrjouy, M, Barnkob, N, Hjalgrim, L, Mathiasen, R, Lautrup, C, Gregersen, P, Hasle, H, Wehner, P, Tuckuviene, R, Sackett, P, Laspiur, A, Rossing, M, Marvig, R, Tommerup, N, Olsen, T, Scheie, D, Gupta, R, Gerdes, A-M, Schmiegelow, K & Wadt, K 2020, ' Nationwide Germline Whole Genome Sequencing of 198 Consecutive Pediatric Cancer Patients Reveals a High Incidence of Cancer Prone Syndromes ', Pediatric Blood & Cancer, vol. 67, no. Suppl .4, 0719, pp. S323 . < https://onlinelibrary.wiley.com/toc/15455017/2020/67/S4 >

PURPOSE: Historically, cancer predisposition syndromes (CPSs) were rarely established for children with cancer. This nationwide, population-based study investigated how frequently children with cancer had or were likely to have a CPS. METHODS: Childr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6228024a6be5c771cf845435951de106
https://doi.org/10.1371/journal.pgen.1009231