Zobrazeno 1 - 10
of 2 520
pro vyhledávání: '"Neoplasms/metabolism"'
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 389-395 (2021)
Introduction: Children and adolescents with cancer are particularly vulnerable to malnutrition and require special attention on nutritional assessment. An adequate nutritional status during treatment is essential in reducing morbidity and mortality,
Externí odkaz:
https://doaj.org/article/f8842576ab4a4afd90a59c02250c8e68
Publikováno v:
Cancer Epidemiology Biomarkers & Prevention. 31(12):2106-2115
Physical activity may reduce the risk of developing breast cancer via its effect on the insulin/insulin-like growth factor (IGF) signaling system. A systematic review searched for randomized controlled trials (RCT), Mendelian randomization and prospe
Publikováno v:
Journal of experimental & clinical cancer research. 42
BACKGROUND: Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to therapy. We studied the expressio
Autor:
Køstner, Anne Helene, Fuglestad, Anniken Jørlo, Georgsen, Jeanette Baehr, Nielsen, Patricia Switten, Christensen, Kristina Bang, Zibrandtsen, Helle, Parner, Erik Thorlund, Rajab, Ibraheem M, Potempa, Lawrence A, Steiniche, Torben, Kersten, Christian
Publikováno v:
Køstner, A H, Fuglestad, A J, Georgsen, J B, Nielsen, P S, Christensen, K B, Zibrandtsen, H, Parner, E T, Rajab, I M, Potempa, L A, Steiniche, T & Kersten, C 2023, ' Fueling the flames of colon cancer-does CRP play a direct pro-inflammatory role? ', Frontiers in Immunology, vol. 14, 1170443 . https://doi.org/10.3389/fimmu.2023.1170443
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists in two structurally and funct
Autor:
Seliger, Corinna, Rauer, Lisa, Wüster, Anne-Louise, Moeckel, Sylvia, Leidgens, Verena, Jachnik, Birgit, Ammer, Laura-Marie, Heckscher, Simon, Dettmer, Katja, Riemenschneider, Markus J., Oefner, Peter J., Proescholdt, Martin A., Vollmann-Zwerenz, Arabel, Hau, Peter
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 4; Pages: 3199
Glioblastomas are highly malignant brain tumors that derive from brain-tumor-initiating cells (BTICs) and can be subdivided into several molecular subtypes. Metformin is an antidiabetic drug currently under investigation as a potential antineoplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7108888aa61a10ac859ffd86185877f
https://epub.uni-regensburg.de/54264/
https://epub.uni-regensburg.de/54264/
Autor:
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Publikováno v:
Nature Communications, 14 (1)
Pavic, K, Gupta, N, Omella, J D, Derua, R, Aakula, A, Huhtaniemi, R, Määttä, J A, Höfflin, N, Okkeri, J, Wang, Z, Kauko, O, Varjus, R, Honkanen, H, Abankwa, D, Köhn, M, Hytönen, V P, Xu, W, Nilsson, J, Page, R, Janssens, V, Leitner, A & Westermarck, J 2023, ' Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A ', Nature Communications, vol. 14, 1143 . https://doi.org/10.1038/s41467-023-36693-9
Pavic, K, Gupta, N, Omella, J D, Derua, R, Aakula, A, Huhtaniemi, R, Määttä, J A, Höfflin, N, Okkeri, J, Wang, Z, Kauko, O, Varjus, R, Honkanen, H, Abankwa, D, Köhn, M, Hytönen, V P, Xu, W, Nilsson, J, Page, R, Janssens, V, Leitner, A & Westermarck, J 2023, ' Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A ', Nature Communications, vol. 14, 1143 . https://doi.org/10.1038/s41467-023-36693-9
The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and structural mechanisms of PP2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a638973e7be8ff61baa72320d130abe
https://trepo.tuni.fi/handle/10024/147130
https://trepo.tuni.fi/handle/10024/147130
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630518
The neutral red uptake (NRU) assay is a cell viability assay that can be used for the assessment of compound-induced cytotoxicity. It is based on the ability of living cells to incorporate neutral red, a weak cationic dye, in lysosomes. The quantific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c00048235960a00fe7fd54bf4e523d
https://hdl.handle.net/20.500.14017/ac107fb2-6fcb-4a33-916d-e820589bc870
https://hdl.handle.net/20.500.14017/ac107fb2-6fcb-4a33-916d-e820589bc870
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3075
Volume 24
Issue 4
Pages: 3075
Glioblastoma multiforme (GBM), a grade IV glioma, is a challenging disease for patients and clinicians, with an extremely poor prognosis. These tumours manifest a high molecular heterogeneity, with limited therapeutic options for patients. Since GBM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c5d60a5669951529f49da29bd929f5
http://orbilu.uni.lu/handle/10993/54560
http://orbilu.uni.lu/handle/10993/54560
Autor:
Beelen, Nicky A, Ehlers, Femke A I, Kooreman, Loes F S, Bos, Gerard M J, Wieten, Lotte, Thomas, Clement, Galluzzi, Lorenzo
Publikováno v:
The Immunological Synapse Part A, 173, 133-153
Methods in Cell Biology ISBN: 9780323901543
Methods in Cell Biology ISBN: 9780323901543
Adoptive natural killer (NK) cell-based immunotherapy poses a promising treatment approach in cancer. Despite minimal toxicities associated with NK cell infusion, the potential of NK cell therapy is inhibited by the immunosuppressive tumor microenvir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317544c2145bd449933b019b00d523c4
https://cris.maastrichtuniversity.nl/en/publications/1e391ac9-001c-46c4-b0a9-710a028c7c64
https://cris.maastrichtuniversity.nl/en/publications/1e391ac9-001c-46c4-b0a9-710a028c7c64
Autor:
Tadashi Matsuda, Kenji Oritani
Publikováno v:
Biological & pharmaceutical bulletin. 44(12):1810-1818
The signal-transducing adaptor protein (STAP) family, including STAP-1 and STAP-2, contributes to a variety of intracellular signaling pathways. The proteins in this family contain typical structures for adaptor proteins, such as Pleckstrin homology