Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Neoplasms/enzymology"'
Autor:
Ahmet Ucar, Adam J. Pearson, Emanuele Giurisato, Fuhui Chen, Brian A. Telfer, Qiuping Xu, Wei Zhang, Katherine G. Finegan, Cathy Tournier, Jingwei Zhang, Nisha Ali, Blanca Risa, Hao Zhang
Publikováno v:
Oncogene
Xu, Q, Zhang, J, Telfer, B A, Zhang, H, Ali, N, Chen, F, Risa, B, Pearson, A J, Zhang, W, Finegan, K G, Ucar, A, Giurisato, E & Tournier, C 2021, ' The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion ', Oncogene, vol. 40, no. 23, pp. 3929-3941 . https://doi.org/10.1038/s41388-021-01798-2
Xu, Q, Zhang, J, Telfer, B A, Zhang, H, Ali, N, Chen, F, Risa, B, Pearson, A J, Zhang, W, Finegan, K G, Ucar, A, Giurisato, E & Tournier, C 2021, ' The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion ', Oncogene, vol. 40, no. 23, pp. 3929-3941 . https://doi.org/10.1038/s41388-021-01798-2
There is overwhelming clinical evidence that the extracellular-regulated protein kinase 5 (ERK5) is significantly dysregulated in human breast cancer. However, there is no definite understanding of the requirement of ERK5 in tumor growth and metastas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896d0c414fb1aed540c0888f7e226723
http://europepmc.org/articles/PMC8195737
http://europepmc.org/articles/PMC8195737
Autor:
Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton
Publikováno v:
Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
Autor:
Alexander So, Mariela Castelblanco, Hans Acha-Orbea, Tomohiro Matsumura, Véronique Chobaz, Nathalie Busso, Teruo Kusano, Takeshi Nishino, Driss Ehirchiou, Ken Okamoto, Sonia Nasi, Christine Lavanchy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature communications, vol. 10, no. 1, pp. 4904
Nature Communications
Nature communications, vol. 10, no. 1, pp. 4904
Nature Communications
Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bc8d18e5e6e17285be9cac5cbdc0f2
https://doaj.org/article/a917fab180ef4bcfad65767813174f1d
https://doaj.org/article/a917fab180ef4bcfad65767813174f1d
Publikováno v:
Biochemical and biophysical research communications, vol. 513, no. 3, pp. 546-552
Whilst effects of anti-cancer drugs have been thoroughly explored, little is known about the repercussion of drug cessation. However, this has important clinical relevance since several clinical protocols such as intermittent drug scheduling lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50127f306a84e9b0f9602438657ddcb
https://doi.org/10.1016/j.bbrc.2019.04.044
https://doi.org/10.1016/j.bbrc.2019.04.044
Autor:
Paulette Bioulac-Sage, Vincent Dunet, Christine Sempoux, Charles Balabaud, Valérie Paradis, Annette S. H. Gouw
Publikováno v:
American Journal of Surgical Pathology, 45(4), 477-487. LIPPINCOTT WILLIAMS & WILKINS
The American journal of surgical pathology, vol. 45, no. 4, pp. 477-487
The American journal of surgical pathology, vol. 45, no. 4, pp. 477-487
Some hepatocellular adenoma (HCA) subtypes are characterized by different CTNNB1 mutations, leading to different beta-catenin activation levels, hence variable immunostaining patterns of glutamine synthetase (GS) expression, and different risks of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf676561e4153b68726a654d05bc846
https://research.rug.nl/en/publications/fbfefb97-661a-4aff-a123-a929e2f58f53
https://research.rug.nl/en/publications/fbfefb97-661a-4aff-a123-a929e2f58f53
Autor:
Anne E. Kiltie, Chee Kin Then, Sophie Ellermann, J.A. Newman, Junetha Syed, Ignacio Torrecilla, Iolanda Vendrell, Kristijan Ramadan, Juri Na, Roman Fischer
Publikováno v:
Cell Death & Disease
Cell death & disease, 12(2). Nature Publishing Group
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
Cell death & disease, 12(2). Nature Publishing Group
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e55e65e62a3c0343b3c0eabc9e8bfa
https://doi.org/10.1038/s41419-021-03437-w
https://doi.org/10.1038/s41419-021-03437-w
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8746, p 8746 (2020)
International Journal of Molecular Sciences, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩
International Journal of Molecular Sciences, Vol 21, Iss 8746, p 8746 (2020)
International Journal of Molecular Sciences, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩
International audience; Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dea2c1fa620f63c25246da202a39d52b
https://pubmed.ncbi.nlm.nih.gov/33228136
https://pubmed.ncbi.nlm.nih.gov/33228136
Autor:
Christine Sempoux, Laurence de Leval, Pedro Romero, Justine Bouilly, Inês Monteiro, João Vasco Santos, Edoardo Missiaglia, Amedeo Sciarra
Publikováno v:
Virchows Archiv
Virchows Archiv, vol. 479, no. 1, pp. 209-214
Virchows Archiv, vol. 479, no. 1, pp. 209-214
CD73 converts AMP to adenosine, an immunosuppressive metabolite that promotes tumorigenesis. This study presents a systematic evaluation of CD73 expression in benign, hyperplastic, and neoplastic thyroid. CD73 expression was assessed by immunohistoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53be8a7b5c8b285a85d9d885655570d3
https://pubmed.ncbi.nlm.nih.gov/34019179
https://pubmed.ncbi.nlm.nih.gov/34019179
Autor:
Sever Nİ, Cengiz Şahin S
S6K2, the newer member of S6 Kinase family, is a crucial modulator of Akt/mTOR signaling pathway and is a member of AGC kinase family that regulates cellular growth and survival. S6K1 and S6K2 share high sequence similarity; therefore, S6K2 had been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3566::e5363f8a19eca66db919f2b666c006db
Autor:
Alfred L. Garfall, Alison K. Spencer, Vasilena Gocheva, Marsha L. Quick, Jemila C. Kester, Robert L. Bowman, Leila Akkari, Johanna A. Joyce
Publikováno v:
Genes and Development, vol. 30, no. 2, pp. 220-232
Proteases are important for regulating multiple tumorigenic processes, including angiogenesis, tumor growth, and invasion. Elevated protease expression is associated with poor patient prognosis across numerous tumor types. Several multigene protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f810c9c89de5e9fcdba280b4411e1958
https://doi.org/10.1101/gad.270439.115
https://doi.org/10.1101/gad.270439.115