Alcohol consumption, DNA methylation and colorectal cancer risk:Results from pooled cohort studies and Mendelian randomization analysis

Autor: Xuan Zhou, Lijuan Wang, Jiarui Xiao, Jing Sun, Lili Yu, Han Zhang, Xiangrui Meng, Shuai Yuan, Maria Timofeeva, Philip J. Law, Richard S. Houlston, Kefeng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li

Publikováno v: Zhou, X, Wang, L, Xiao, J, Sun, J, Yu, L, Zhang, H, Meng, X, Yuan, S, Timofeeva, M, Law, P J, Houlston, R S, Ding, K, Dunlop, M G, Theodoratou, E & Li, X 2022, ' Alcohol consumption, DNA methylation and colorectal cancer risk : Results from pooled cohort studies and Mendelian randomization analysis ', International Journal of Cancer, vol. 151, no. 1, pp. 83-94 . https://doi.org/10.1002/ijc.33945

Alcohol consumption is thought to be one of the modifiable risk factors for colorectal cancer (CRC). However, the causality and mechanisms by which alcohol exerts its carcinogenic effect are unclear. We evaluated the association between alcohol consu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387e6ec3a1c1d9acc9a11f893f6e495c
https://hdl.handle.net/20.500.11820/df01f2d1-dcc2-408e-9fa9-6bb5b0d8f4a2

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

Autor: Tracy O'Mara, Maxine Chen, Sally-Anne Mortlock, Dale Nyholt, Stuart MacGregor, Leanne WALLACE, Montserrat Garcia-Closas, Jolanta Lissowska, Krina Zondervan, Mark McEvoy, Peter Rogers, Mette Nyegaard

Publikováno v: Kho, P F, Mortlock, S, Endometrial Cancer Association Consortium, International Endometriosis Genetics Consortium, Rogers, P A W, Nyholt, D R, Montgomery, G W, Spurdle, A B, Glubb, D M, O'Mara, T A & Nyegaard, M 2021, ' Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus ', Human Genetics, vol. 140, no. 9, pp. 1353-1365 . https://doi.org/10.1007/s00439-021-02312-0

Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd533e78d75b151c7576c0aa30e47b1e
https://vbn.aau.dk/da/publications/d0b9177f-5536-4dbc-8363-0715ee0880dc

KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

Autor: Robert E. Lewis, Robert A. Svoboda, Kurt W. Fisher, Chaitra Rao, Hans Clevers, Chittibabu Guda, Adrian R. Black, Siddesh Southekal, Tomohiro Mizutani, Danielle E. Frodyma, Keith R. Johnson

Publikováno v: eLife, 10. eLife Sciences Publications
eLife, Vol 10 (2021)
eLife

The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bb2042ad67232ddc7d12f35e2d41bc
https://pure.knaw.nl/portal/en/publications/a93f93c2-06c8-4529-b2df-02797c4ce103

ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

Autor: Jane E. Aubin, Geoffrey Vargas, Edith Bonnelye, Sophie Vacher, Marie Brevet, Pascal Reboul, M Filipits, Ivan Bièche, C Boyault, W Jacot, Lamia Bouazza, Sandra Geraci, Keltouma Driouch, Francesco Pantano, Michael Gnant, Catherine Alix-Panabières, M Gervais, Laure Cayrefourcq, Philippe Clézardin, M Bouchet, M Mazel, Martine Croset, Claire Benetollo, C Kan, Martine Duterque-Coquillaud

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3 ⟩
Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩
Oncogene, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩

International audience; Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we established that ERRα promotes spontaneous metastatic dissemination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673afe46894df907867170c048c800d7
http://hdl.handle.net/20.500.12210/55264

A no-stop mutation in MAGEB4 is a possible cause of rare X-linked azoospermia and oligozoospermia in a consanguineous Turkish family

Autor: Moncef Benkhalifa, Stéphane Viville, Sabine Kliesch, Nicolas Charlet-Berguerand, Munevver Serdarogullari, Angeline Gaucherot, Isabelle Aknin, Ozlem Okutman, Frank Tüttelmann, Viviana Herbepin, Mustafa Bahceci, Meral Gultomruk, Ellen Goossens, Jean Marie Garnier, Valérie Lamour, Yoni Baert, Jean Muller, Emre Bakircioglu, Valerie Skory, Marius Teletin, Albrecht Röpke

Publikováno v: Journal of Assisted Reproduction and Genetics
Journal of Assisted Reproduction and Genetics, Springer Verlag, 2017, 34 (5), pp.683-694. ⟨10.1007/s10815-017-0900-z⟩
Journal of Assisted Reproduction and Genetics, 2017, 34 (5), pp.683-694. ⟨10.1007/s10815-017-0900-z⟩

PURPOSE: The purpose of this study was to identify mutations that cause non-syndromic male infertility using whole exome sequencing of family cases. METHODS: We recruited a consanguineous Turkish family comprising nine siblings with male triplets; tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fa96f08dd57f5a681ab1fecadd8899
https://doi.org/10.1007/s10815-017-0900-z