Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling

Autor: Juilland, M., Thome, M.

Publikováno v: Frontiers in immunology, vol. 9, pp. 1927

The scaffold proteins CARMA1-3 (encoded by the genes CARD11, -14 and -10) and CARD9 play major roles in signaling downstream of receptors with immunoreceptor tyrosine activation motifs (ITAMs), G-protein coupled receptors (GPCR) and receptor tyrosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::8d78291d5c1e5e91f3e36b59bf85c7e4
https://serval.unil.ch/notice/serval:BIB_7A5968ADA94D

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination

Autor: Daniel E. Speiser, Pedro Romero, Laurent Derré, Camilla Jandus, Olivier Michielin, Daniel Olive, Sonia Pastor, Jean-Paul Rivals, Donata Rimoldi

Publikováno v: Journal of Clinical Investigation, vol. 120, no. 1, pp. 157-167
Derré, Laurent; Rivals, Jean-Paul; Jandus, Camilla; Pastor, Sonia; Rimoldi, Donata; Romero, Pedro; Michielin, Olivier; Olive, Daniel; Speiser, Daniel E (2010). BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. Journal of clinical investigation, 120(1), pp. 157-67. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI40070

The function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4) and programmed cell death 1 (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21284e9eff3c34c2f726a6abd031552
https://doi.org/10.1172/jci40070

Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells

Autor: A. Karolina Palucka, Donata Rimoldi, Jean Davoust, Patrick Blanco, Jean Charles Cerottini, Mahyar Nouri-Shirazi, Nicolas Taquet, Eve-Marie Neidhart-Berard, Jacques Banchereau, Frederic Berard

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 192, no. 11, pp. 1535-44

The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T cell clones against multiple tumor antigens. This could be obtained using the antigen present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016a1cace8515d94fea44e0c56ccf805
https://doi.org/10.1084/jem.192.11.1535

Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues

Autor: Petra Baumgaertner, Laurent Derré, Pedro Romero, Nathalie Rufer, Marc Bruyninx, Daphné Schmid, Daniel E. Speiser, Mathias Ferber, Vincent Zoete, Antoine Leimgruber, Olivier Michielin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 39, pp. 15010-15015

Naturally acquired immune responses against human cancers often include CD8+T cells specific for the cancer testis antigen NY-ESO-1. Here, we studied T cell receptor (TCR) primary structure and function of 605 HLA-A*0201/NY-ESO-1157–165-specific CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606501cad886f8a6113771e2d4e2b318
https://pubmed.ncbi.nlm.nih.gov/18809922

In Vivo Persistence of Codominant Human CD8+ T Cell Clonotypes Is Not Limited by Replicative Senescence or Functional Alteration

Autor: Marc Bruyninx, Estelle Devevre, Pedro Romero, Patricia Corthesy, Nathalie Rufer, Laurent Derré, Cédric Touvrey, Verena Voelter, Hanspeter Pircher, Daniel E. Speiser, Petra Baumgaertner, Yolanda D. Mahnke

Publikováno v: Journal of Immunology, vol. 179, no. 4, pp. 2368-2379
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 179 (4), pp.2368-2379. ⟨10.4049/jimmunol.179.4.2368⟩

T cell responses to viral epitopes are often composed of a small number of codominant clonotypes. In this study, we show that tumor Ag-specific T cells can behave similarly. In a melanoma patient with a long lasting HLA-A2/NY-ESO-1-specific T cell re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b4edcb9a614d3b245cc5c5689af6f8
https://serval.unil.ch/notice/serval:BIB_96E2EC572F21