Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Neoplasias [ENFERMEDADES]"'
Autor:
Vivek Subbiah, Robert J. Kreitman, Zev A. Wainberg, Anas Gazzah, Ulrik Lassen, Alexander Stein, Patrick Y. Wen, Sascha Dietrich, Maja J. A. de Jonge, Jean-Yves Blay, Antoine Italiano, Kan Yonemori, Daniel C. Cho, Filip Y. F. L. de Vos, Philippe Moreau, Elena Elez Fernandez, Jan H. M. Schellens, Christoph C. Zielinski, Suman Redhu, Aislyn Boran, Vanessa Q. Passos, Palanichamy Ilankumaran, Yung-Jue Bang
Publikováno v:
Nature medicine, vol 29, iss 5
Scientia
Nature Medicine, 29(5), 1103-1112. Nature Publishing Group
Scientia
Nature Medicine, 29(5), 1103-1112. Nature Publishing Group
BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4ebaa45d1da62d0ac5f9e5a60659de
http://www.scopus.com/inward/record.url?scp=85152683237&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85152683237&partnerID=8YFLogxK
Publikováno v:
Scientia
Introduction Identifying polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) gene is gaining importance to be able to predict fluoropyrimidine-associated toxicity. The aim of this project was to describe the frequency of the DPYD variants DPY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6ba0b4b10b7e7a80c2356c440bae04
https://doi.org/10.1093/oncolo/oyad077
https://doi.org/10.1093/oncolo/oyad077
Autor:
Z, Kuzbari, C, Bandlamudi, C, Loveday, A, Garrett, M, Mehine, A, George, H, Hanson, K, Snape, A, Kulkarni, S, Allen, S, Jezdic, R, Ferrandino, C B, Westphalen, E, Castro, J, Rodon, J, Mateo, G J, Burghel, M F, Berger, D, Mandelker, C, Turnbull
Publikováno v:
Scientia
Germline; Tumour-only sequencing Línia germinal; Seqüenciació només de tumors Línea germinal; Secuenciación solo de tumors Background The European Society for Medical Oncology Precision Medicine Working Group (ESMO PMWG) was reconvened to updat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff765a5346fd311ae520e0d112a204fb
https://doi.org/10.1016/j.annonc.2022.12.003
https://doi.org/10.1016/j.annonc.2022.12.003
Autor:
Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S. Walter, Sarah Blagden, Alan Anthoney, Barbara J. Klencke, Mark M. Kowalski, Udai Banerji
Publikováno v:
Scientia
Gemcitabina; Cáncer avanzado Gemcitabina; Càncer avançat Gemcitabine; Advanced cancer Purpose: This was a Phase I/II trial of the novel checkpoint kinase 1 (Chk1) inhibitor SRA737 given in combination with gemcitabine. Its objectives were to estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b8b8b6c13c4102f92013713c378bda
https://doi.org/10.1158/1078-0432.ccr-22-2074
https://doi.org/10.1158/1078-0432.ccr-22-2074
Autor:
Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul
Publikováno v:
Scientia
Biological activity; Solid tumors Actividad biológica; Tumores sólidos Activitat biològica; Tumors sòlids A phase I trial (NCT03447314; 204686) evaluated the safety and efficacy of GSK1795091, a Toll-like receptor 4 (TLR4) agonist, in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a2c776e6853dfc712d9d3e7b04e11
https://doi.org/10.1111/cts.13387
https://doi.org/10.1111/cts.13387
Autor:
Lucas Moreno, Steven G. DuBois, Julia Glade Bender, Audrey Mauguen, Nick Bird, Vickie Buenger, Michela Casanova, François Doz, Elizabeth Fox, Lia Gore, Douglas S. Hawkins, Shai Izraeli, David T.W. Jones, Pamela R. Kearns, Jan J. Molenaar, Karsten Nysom, Stefan Pfister, Gregory Reaman, Malcolm Smith, Brenda Weigel, Gilles Vassal, Christian Michel Zwaan, Xavier Paoletti, Alexia Iasonos, Andrew D.J. Pearson
Publikováno v:
Scientia
PURPOSE There is an increasing need to evaluate innovative drugs for childhood cancer using combination strategies. Strong biological rationale and clinical experience suggest that multiple agents will be more efficacious than monotherapy for most di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cfed0b001a0a7bb4dbc82e8b4ec2a0
https://hdl.handle.net/11351/9922
https://hdl.handle.net/11351/9922
Autor:
Maria Lozano-Rabella, Andrea Garcia-Garijo, Jara Palomero, Anna Yuste-Estevanez, Florian Erhard, Roc Farriol-Duran, Juan Martín-Liberal, Maria Ochoa-de-Olza, Ignacio Matos, Jared J. Gartner, Michael Ghosh, Francesc Canals, August Vidal, Josep Maria Piulats, Xavier Matías-Guiu, Irene Brana, Eva Muñoz-Couselo, Elena Garralda, Andreas Schlosser, Alena Gros
Publikováno v:
Scientia
Immunogenicity; Proteogenomics Inmunogenicidad; Proteogenómica Immunogenicitat; Proteogenòmica Purpose: Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from noncanonical (nonC) aberrantly translated proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe8c7b8c02cd12225ff5cd0e3f083be
https://hdl.handle.net/11351/9824
https://hdl.handle.net/11351/9824
Autor:
Jason J. Luke, Marwan Fakih, Charles Schneider, E. Gabriela Chiorean, Johanna Bendell, Rebecca Kristeleit, Razelle Kurzrock, Sarah P. Blagden, Irene Brana, Laura W. Goff, Kevin O’Hayer, Ryan Geschwindt, Michael Smith, Feng Zhou, Aung Naing
Publikováno v:
Scientia
Background Indoleamine 2,3-dioxygenase 1 (IDO1), an interferon-inducible enzyme, contributes to tumor immune intolerance. Immune checkpoint inhibition may increase interferon levels; combining IDO1 inhibition with immune checkpoint blockade represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a86bc969a7907b279383b86ec75a315
https://hdl.handle.net/11351/9837
https://hdl.handle.net/11351/9837
Autor:
Ferrara, Gia, Aguina, Molly, Mirochnick, Emily, Wiphatphumiprates, Parima, Moreira, Daniel, Sniderman, Elizabeth, VELASCO, PABLO
Publikováno v:
Scientia
Pediatric cancer; Psychosocial studies; Quality of life Càncer pediàtric; Estudis psicosocials; Qualitat de vida Cáncer pediátrico; Estudios psicosociales; Calidad de vida Background The COVID-19 pandemic altered healthcare systems globally, caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3991::3e61c8229948ac787ea1e2410cbc28a0
https://hdl.handle.net/11351/9963
https://hdl.handle.net/11351/9963
Publikováno v:
Scientia
Càncer; Planificació sanitària; Catalunya Cancer; Health planning; Catalonia Cáncer; Planificación sanitaria; Cataluña En aquest document es presenta una avaluació de l’impacte del càncer a Catalunya fins al 2025 (any triat per seguir la me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3991::0a8902478970ab9e4c3d25375c3006a5
https://hdl.handle.net/11351/9855
https://hdl.handle.net/11351/9855