Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Neophytos Kouphou"'
Autor:
Nathan J Cheetham, Milla Kibble, Andrew Wong, Richard J Silverwood, Anika Knuppel, Dylan M Williams, Olivia KL Hamilton, Paul H Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B Ploubidis, Ellen J Thompson, Ruth CE Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H Malim, Ruth E Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex SF Kwong, Katie Doores, Nishi Chaturvedi, Emma L Duncan, Nicholas J Timpson, Claire J Steves
Publikováno v:
eLife, Vol 12 (2023)
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher levels of SARS-CoV
Externí odkaz:
https://doaj.org/article/3b470fcd4a024f3f9f98813d3730e991
Autor:
Nicola Sweeney, Blair Merrick, Rui Pedro Galão, Suzanne Pickering, Alina Botgros, Harry D Wilson, Adrian W Signell, Gilberto Betancor, Mark Kia Ik Tan, John Ramble, Neophytos Kouphou, Sam Acors, Carl Graham, Jeffrey Seow, Eithne MacMahon, Stuart J D Neil, Michael H Malim, Katie Doores, Sam Douthwaite, Rahul Batra, Gaia Nebbia, Jonathan D Edgeworth
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249791 (2021)
During the first wave of the global COVID-19 pandemic the clinical utility and indications for SARS-CoV-2 serological testing were not clearly defined. The urgency to deploy serological assays required rapid evaluation of their performance characteri
Externí odkaz:
https://doaj.org/article/2e399c613b574b219ea8a3ec333a2c1b
Autor:
Suzanne Pickering, Gilberto Betancor, Rui Pedro Galão, Blair Merrick, Adrian W Signell, Harry D Wilson, Mark Tan Kia Ik, Jeffrey Seow, Carl Graham, Sam Acors, Neophytos Kouphou, Kathryn J A Steel, Oliver Hemmings, Amita Patel, Gaia Nebbia, Sam Douthwaite, Lorcan O'Connell, Jakub Luptak, Laura E McCoy, Philip Brouwer, Marit J van Gils, Rogier W Sanders, Rocio Martinez Nunez, Karen Bisnauthsing, Geraldine O'Hara, Eithne MacMahon, Rahul Batra, Michael H Malim, Stuart J D Neil, Katie J Doores, Jonathan D Edgeworth
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008817 (2020)
There is a clear requirement for an accurate SARS-CoV-2 antibody test, both as a complement to existing diagnostic capabilities and for determining community seroprevalence. We therefore evaluated the performance of a variety of antibody testing tech
Externí odkaz:
https://doaj.org/article/9e47f97b555e4d8f826354c685f40001
Autor:
Nathan J Cheetham, Milla Kibble, Andrew Wong, Richard J Silverwood, Anika Knuppel, Dylan M Williams, Olivia KL Hamilton, Paul H Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B Ploubidis, Ellen J Thompson, Ruth CE Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H Malim, Ruth E Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex SF Kwong, Katie Doores, Nishi Chaturvedi, Emma L Duncan, Nicholas J Timpson, Claire J Steves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e00db25466fd2b79f0be05df8a35437
https://doi.org/10.7554/elife.80428.sa2
https://doi.org/10.7554/elife.80428.sa2
Autor:
Jia Zhe Su, Michael H. Malim, Daniel Cox, Neophytos Kouphou, Sam Acors, Carl Graham, Ana Maria Ortega-Prieto, Luke B Snell, Cassandra Fairhead, Stuart J. D. Neil, Liane Dupont, Helena Winstone, Thomas Lechmere, Rui Pedro Galão, Sadie R. Hallett, Gaia Nebbia, Isabella Huettner, Nathalia Almeida, Marie Jose Lista, Adela Alcolea-Medina, Thomas J. A. Maguire, Suzanne Pickering, Manu Shankar-Hari, Rahul Batra, Jonathan D. Edgeworth, Jose M. Jimenez-Guardeño, Katie J. Doores, Ruth E Dickenson, Jeffrey Seow, Themoula Charalampous, Harry Wilson, Blair Merrick
Publikováno v:
Nature Microbiology
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
Dupont, L, Snell, L B, Graham, C, Seow, J, Merrick, B, Lechmere, T, Maguire, T J A, Hallett, S R, Pickering, S, Charalampous, T, Alcolea-Medina, A, Huettner, I, Jimenez-Guardeño, J M, Acors, S, Almeida, N, Cox, D, Dickenson, R E, Galao, R P, Kouphou, N, Lista, M J, Ortega-Prieto, A M, Wilson, H, Winstone, H, Fairhead, C, Su, J Z, Nebbia, G, Batra, R, Neil, S, Shankar-Hari, M, Edgeworth, J D, Malim, M H & Doores, K J 2021, ' Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern ', Nature Microbiology, vol. 6, no. 11, pp. 1433-1442 . https://doi.org/10.1038/s41564-021-00974-0
COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses of convalescent sera provi
Autor:
Julia S. El-Sayed Moustafa, Anne U. Jackson, Sarah M. Brotman, Li Guan, Sergio Villicaña, Amy L. Roberts, Antonino Zito, Lori Bonnycastle, Michael R. Erdos, Narisu Narisu, Heather M. Stringham, Ryan Welch, Tingfen Yan, Timo Lakka, Stephen Parker, Jaakko Tuomilehto, Jeffrey Seow, Carl Graham, Isabella Huettner, Sam Acors, Neophytos Kouphou, Samuel Wadge, Emma L. Duncan, Claire J. Steves, Katie J. Doores, Michael H. Malim, Francis S. Collins, Päivi Pajukanta, Michael Boehnke, Heikki A. Koistinen, Markku Laakso, Mario Falchi, Jordana T. Bell, Laura J. Scott, Karen L. Mohlke, Kerrin S. Small
Background COVID-19 severity varies widely. Although some demographic and cardio-metabolic factors, including age and obesity, are associated with increasing risk of severe illness, the underlying mechanism(s) are uncertain. Subjects/methods In a met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8dc312d4f924b005861eb6f705e43c
http://hdl.handle.net/10138/346665
http://hdl.handle.net/10138/346665
Autor:
Nathan J. Cheetham, Milla Kibble, Andrew Wong, Richard J. Silverwood, Anika Knuppel, Dylan M. Williams, Olivia K. L. Hamilton, Paul H. Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B. Ploubidis, Ellen J. Thompson, Ruth C. E. Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H. Malim, Ruth E. Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex S. F. Kwong, Katie J. Doores, Nishi Chaturvedi, Emma L. Duncan, Nicholas J. Timpson, Claire J. Steves
SARS-CoV-2 antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. From cross-sectional antibody testing of 9,361 individuals from TwinsUK and ALSPAC UK p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93be47a54c39dffd6263121637084f9f
https://doi.org/10.1101/2022.05.19.22275214
https://doi.org/10.1101/2022.05.19.22275214
Autor:
Ana Maria Ortega-Prieto, Cassandra Fairhead, Carl Graham, Themoula Charalampous, Harry Wilson, Stuart J. D. Neil, Jose M. Jimenez-Guardeño, Neophytos Kouphou, Thomas Lechmere, Helena Winstone, Rui Pedro Galão, Jeffrey Seow, Michael H. Malim, Isabella Huettner, Ruth E Dickenson, Liane Dupont, Rahul Batra, Jia Su, Marie Jose Lista, Adela Alcolea-Medina, Daniel Cox, Gaia Nebbia, Katie J. Doores, Luke B Snell, Jonathan D. Edgeworth, Manu Shankar-Hari, Nathalia Almeida, Sam Acors, Suzanne Pickering, Blair Merrick, Thomas J. A. Maguire, Sadie R. Hallett
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
As SARS-CoV-2 variants continue to emerge globally, a major challenge for COVID-19 vaccination is the generation of a durable antibody response with cross-neutralizing activity against both current and newly emerging viral variants. Cross-neutralizin
Autor:
Carl Graham, Jeffrey Seow, Isabella Huettner, Hataf Khan, Neophytos Kouphou, Sam Acors, Helena Winstone, Suzanne Pickering, Rui Pedro Galao, Maria Jose Lista, Jose M Jimenez-Guardeno, Adam G. Laing, Yin Wu, Magdalene Joseph, Luke Muir, Weng M Ng, Helen M. E. Duyvesteyn, Yuguang Zhao, Thomas A. Bowden, Manu Shankar-Hari, Annachiara Rosa, Peter Cherepanov, Laura E McCoy, Adrian C Hayday, Stuart J.D. Neil, Michael H Malim, Katie J Doores
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The interaction of the SARS–CoV–2 Spike receptor binding domain (RBD) with the ACE2 receptor on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies and several neutralizing epitopes on RBD have been mol
Autor:
Neophytos Kouphou, Nicola Sweeney, Alina Botgros, Blair Merrick, Sam Douthwaite, Sam Acors, Adrian W. Signell, Gilberto Betancor, Rahul Batra, Rui Pedro Galão, Harry Wilson, Mark Kia Ik Tan, Jeffrey Seow, Michael H. Malim, Carl Graham, Gaia Nebbia, Jonathan D. Edgeworth, Eithne MacMahon, Katie J. Doores, John Ramble, Suzanne Pickering, Stuart J. D. Neil
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249791 (2021)
PLoS ONE
PLoS ONE
During the first wave of the global COVID-19 pandemic the clinical utility and indications for SARS-CoV-2 serological testing were not clearly defined. The urgency to deploy serological assays required rapid evaluation of their performance characteri