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Translational pharmacokinetic and pharmacodynamic modelling of the anti-ADAMTS-5 NANOBODY ^® (M6495) using the neo-epitope ARGS as a biomarker.

Autor: Pereira JNS; The Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany. joao.ns.pereira@merckgroup.com., Ottevaere I; Sanofi Ghent, Technologiepark 21, Zwijnaarde, B-9052, Belgium.; Present Address: argenx BVBA, Ghent, Belgium., Serruys B; Sanofi Ghent, Technologiepark 21, Zwijnaarde, B-9052, Belgium., Guehring H; The Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany., Ladel C; The Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.; Present Address: Independent Consultant, Darmstadt, Germany., Lindemann S; The Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany. sven.lindemann@merckgroup.com.

Publikováno v: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2024 Dec 20; Vol. 52 (1), pp. 8. Date of Electronic Publication: 2024 Dec 20.

Biglycan neo-epitope (BGN262), a novel biomarker for screening early changes in equine osteoarthritic subchondral bone

Autor: Adepu, S. ^{†, ∗}, Ekman, S. ^†, Leth, J. ^‡, Johansson, U. ^†, Lindahl, A. ^§, Skiöldebrand, E. ^†

Publikováno v: In Osteoarthritis and Cartilage October 2022 30(10):1328-1336

Specific Calprotectin Neo-epitope [CPa9-HNE] in Serum from Inflammatory Bowel Disease Patients Is Associated with Neutrophil Activity and Endoscopic Severity.

Autor: Mortensen, Joachim Høg¹ (AUTHOR) jhm@nordicbio.com, Sinkeviciute, Dovile^1,2 (AUTHOR), Manon-Jensen, Tina¹ (AUTHOR), Domislović, Viktor³ (AUTHOR), McCall, Kathryn⁴ (AUTHOR), Thudium, Christian S¹ (AUTHOR), Brinar, Marko³ (AUTHOR), Önnerfjord, Patrik² (AUTHOR), Goodyear, Carl S⁴ (AUTHOR), Krznarić, Željko³ (AUTHOR), Karsdal, Morten Asser¹ (AUTHOR), Bay-Jensen, Anne-Christine¹ (AUTHOR)

Publikováno v: Journal of Crohn's & Colitis. Sep2022, Vol. 16 Issue 9, p1447-1460. 14p.

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