Výsledky vyhledávání - "Neo C. Hoang"

A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms

Autor: Victoria A. Engel, Yangshin Park, Neo C. Hoang, Li Wan, Ruslan Sanishvili, Mu Wang, Alexandra Beilina, Mark R. Cookson, Jingling Liao, Misook Oh, Chun-Xiang Wu, Xylena Reed, Yuichiro Takagi, Steven M. Johnson, Mark Federici, Quyen Q. Hoang, R. Jeremy Nichols

Leucine-rich repeat kinase 2 (LRRK2) is a large 286 kDa multi-domain protein whose mutation is a common cause of Parkinson’s disease (PD). One of the common sites of familial PD-associated mutations occurs at residue Arg-1441 in the GTPase domain o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20427395ab0d2d9d90f7388d1038b9f9

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Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics

Autor: Yangshin Park, Xylena Reed, Mark Federici, Yuichiro Takagi, Ruslan Sanishvili, Mu Wang, Quyen Q. Hoang, Jingling Liao, R. Jeremy Nichols, Neo C. Hoang, Mark R. Cookson, Steven M. Johnson, Chun-Xiang Wu, Victoria A. Engel

Publikováno v: The Journal of biological chemistry. 294(15)

Mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). Recently, we showed that a disease-associated mutation R1441H rendered the GTPase domain of LRRK2 catalytically less active and thereby trapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb3e96a808232699e93bb6cd87d6ac1
https://pubmed.ncbi.nlm.nih.gov/30796162

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