Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Nening Dennis"'
3
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
Autor: Luke Marsden, Colin Cooper, Jorge Zamora, Barbara Kremeyer, Jonathan Kay, Steven Hazell, Mahbubl Ahmed, Tim Dudderidge, Edward Rowe, Hongwei Zhang, William Howat, Freddie C. Hamdy, Tapio Visakorpi, Paul C. Boutros, Gunes Gundem, Bissan Al-Lazikani, S. Edwards, David C. Wedge, Inigo Martincorena, Charles E. Massie, Douglas F. Easton, Gerhardt Attard, Nicholas van As, Anne Y. Warren, Dan J. Woodcock, Naomi Livni, Johann S. de Bono, Nening Dennis, Adam Lambert, Clare Verrill, Alan Thompson, Niedzica Camacho, Daniel Leongamornlert, William B. Isaacs, Christopher S. Foster, Hayley C. Whitaker, Pardeep Kumar, Daniel Brewer, Christopher Greenman, Declan Cahill, Simon Tavaré, Yong-Jie Lu, Stuart McLaren, Ultan McDermott, David T. Jones, Sue Merson, Rosalind A. Eeles, Vincent Khoo, Steve Hawkins, Daniel M. Berney, Cyril Fisher, Hayley J. Luxton, Lucy Matthews, Ludmil B. Alexandrov, G. Steven Bova, Adam Butler, David Nicol, Andy G. Lynch, Michael Fraser, Tokhir Dadaev, Keiran Raine, Mohammed J. R. Ghori, Katalin Karaszi, Jon W. Teague, Chris Sander, Robert G. Bristow, Peter Van Loo, Nimish Shah, Chris Ogden, Paul Workman, Andrew Menzies, Lucy Stebbings, Stefan C. Dentro, Cathy Corbishley, Thomas J. Mitchell, Zsofia Kote-Jarai, Pelvender Gill, Andrew Futreal, Elizabeth Bancroft, David E. Neal, Sarah Thomas, Anthony C. H. Ng, Erik Mayer, Yongwei Yu, Vincent Gnanapragasam, Valeria Bo
Publikováno v: Nature genetics, vol 50, iss 5
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3ffd6b6e74bb3d2b3dcdbbf64a4967
http://ora.ox.ac.uk/objects/uuid:
Zobrazit plný text záznamu
4
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
Autor: Jeremy Clark, Adam Lambert, Clare Verrill, Naomi Livni, Niedzica Camacho, Nimish Shah, Pardeep Kumar, Christopher S. Foster, Keiran Raine, Mohammed J. R. Ghori, David E. Neal, Rosalind A. Eeles, David C. Wedge, Gill Pelvender, Hayley J. Luxton, Steve Hawkins, Erik Mayer, Hongwei Zhang, William B. Isaacs, David Nicol, Colin Cooper, Katalin Karaszi, Charles E. Massie, Chris Ogden, Yong-Jie Lu, William J. Howat, Cyril Fisher, Anne Y. Warren, Sue Merson, Adam Butler, Ultan McDermott, Gunes Gundem, Peter Van Loo, Andy G. Lynch, Jorge Zamora, Luke Marsden, Daniel M. Berney, Barbara Kremeyer, Jonathan D. Kay, Freddie C. Hamdy, Steven Hazell, Tim Dudderidge, Vincent Jeyaseelan Gnanapragasam, Hayley C. Whitaker, Daniel Brewer, David T. Jones, Yongwei Yu, Lucy Matthews, S. Edwards, Sarah Thomas, Tapio Visakorpi, Kerstin Haase, Nening Dennis, Alan Thompson, G. Steven Bova, Zsofia Kote-Jarai
Publikováno v: PLoS Genetics
Camacho, N, Van Loo, P, Edwards, S, Kay, J D, Matthews, L, Haase, K, Clark, J, Dennis, N, Thomas, S, Kremeyer, B, Zamora, J, Butler, A P, Gundem, G, Merson, S, Luxton, H, Hawkins, S, Ghori, M, Marsden, L, Lambert, A, Karaszi, K, Pelvender, G, Massie, C E, Kote-Jarai, Z S, Raine, K, Jones, D, Howat, W J, Hazell, S, Livni, N, Fisher, C, Ogden, C, Kumar, P, Thompson, A, Nicol, D, Mayer, E, Dudderidge, T, Yu, Y, Zhang, H, Shah, N C, Gnanapragasam, V J, Isaacs, W, Visakorpi, T, Hamdy, F, Berney, D, Verrill, C, Warren, A Y, Wedge, D C, Lynch, A G, Foster, C S, Lu, Y J, Bova, G S, Whitaker, H C, McDermott, U, Neal, D E, Eeles, R, Cooper, C S & Brewer, D S 2017, ' Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1007001
PLoS Genetics, Vol 13, Iss 9, p e1007001 (2017)
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b33623a5f7d436ea4c8a3a65c23b69
https://www.repository.cam.ac.uk/handle/1810/273974
Zobrazit plný text záznamu
5
Mutational signatures of ionizing radiation in second malignancies
Autor: Hayley J. Luxton, David Nicol, Chris Ogden, Tokhir Dadaev, Katalin Karaszi, Douglas F. Easton, David E. Neal, Michael R. Stratton, David C. Wedge, Adam Butler, William J. Howat, Jon W. Teague, Sam Behjati, Elizabeth Bancroft, Susanna L. Cooke, Yongwei Yu, Barbara Kremeyer, Peter Van Loo, Pardeep Kumar, Freddie C. Hamdy, Helen Davies, Gunes Gundem, Simon Tavaré, Sarah Thomas, Christopher S. Foster, Anthony C. H. Ng, Erik Mayer, Naomi Livni, Niedzica Camacho, Sarah O’Meara, Cyril Fisher, Gill Pelvender, Nening Dennis, Ultan McDermott, David T. Jones, Jorge Zamora, Adam Lambert, Andy G. Lynch, Mette Jorgensen, Manasa Ramakrishna, Bhavisha Khatri, Andy Menzies, Steven Hazell, Nimish Shah, Susan Merson, Jilur Ghori, Rosalind A. Eeles, Yong-Jie Lu, Anne Y. Warren, Claire Hardy, Adrienne M. Flanagan, Rebecca Shepherd, Tim Dudderidge, Jonathan Kay, Calli Latimer, Ludmil B. Alexandrov, G. Steven Bova, Patrick S. Tarpey, Serena Nik-Zainal, Claire Verrill, Hongwei Zhang, Steve Hawkins, P. Andrew Futreal, Christopher Greenman, Peter J. Campbell, Daniel Leongamornlert, Nischalan Pillay, Keiran Raine, Charlie E. Massi, Sandra L. Edwards, Alan J. Thompson, Lucy Matthews, Cathy Corbishley, Andrea L. Richardson, Adam Shlien, Lucy Stebbings, Christophe Badie, Hayley C. Whitaker, Nicola D. Roberts, Vincent J. Gnanapragasam, Zsofia Kote-Jarai, Daniel M. Berney, Colin Cooper, Daniel Brewer
Publikováno v: Europe PubMed Central
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Behjati, S, Gundem, G, Wedge, DC, Roberts, ND, Tarpey, PS, Cooke, SL, Van, L P, Alexandrov, LB, Ramakrishna, M, Davies, H, Nik-Zainal, S, Hardy, C, Latimer, C, Raine, KM, Stebbings, L, Menzies, A, Jones, D, Shepherd, R, Butler, AP & Teague, JW 2016, ' Mutational signatures of ionizing radiation in second malignancies. ', Nature Communications, vol. 7 . https://doi.org/10.1038/ncomms12605
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32a7d5e46ccdd97f9b6dec571c3de76
https://www.nature.com/articles/ncomms12605#supplementary-information
Zobrazit plný text záznamu
6
Stem cell factor as a novel diagnostic marker for early malignant germ cells
Autor: Brenda Summersgill, Alan McIntyre, R.R. de Krijger, A. J. M. Gillis, Friedemann Honecker, Hans Stoop, Janet Shipley, Martine Cools, Carsten Bokemeyer, Katja P. Wolffenbuttel, Nening Dennis, J. W. Oosterhuis, Lhj Looijenga, Sls Drop, Gjm van de Geijn, M de Boer
Publikováno v: Journal of Pathology, 216(1), 43-54. John Wiley & Sons Ltd.
Carcinoma in situ (CIS) of the testis is the pre-invasive stage of type 11 testicular germ cell tumours (TGCTs) of adolescents and adults. These tumours are the most frequently diagnosed cancer in Caucasian adolescents and young adults. In dysgenetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6876a620da71600674b457aca85cb1
https://doi.org/10.1002/path.2378
Zobrazit plný text záznamu
7
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
Autor: Michael R. Stratton, Gunes Gundem, Victoria Goody, Laura Mudie, Cyril Fisher, Olivia Joseph, Stuart McLaren, Colin Cooper, Ben Robinson, Andrew Futreal, Paul C. Boutros, Rachel Hurst, Pardeep Kumar, Lucy Matthews, Daniel Leongamornlert, Charles E. Massie, Ludmil B. Alexandrov, Robert G. Bristow, Adam Butler, Mark Maddison, Rosalind A. Eeles, Hayley J. Luxton, David Nicol, Serena Nik-Zainal, Jon W. Teague, Jeremy Clark, Christopher Greenman, Douglas F. Easton, Chris Ogden, Peter Van Loo, Zsofia Kote-Jarai, Michael Fraser, Elizabeth Anderson, Hayley C. Whitaker, Ultan McDermott, Susanna L. Cooke, Barbara Kremeyer, Andrew Menzies, Daniel Brewer, David E. Neal, Anne Y. Warren, Naomi Livni, Manasa Ramakrishna, Jon Hinton, Niedzica Camacho, Andy G. Lynch, Richard Mithen, Jonathan Kay, Claire Hardy, Daniel M. Berney, Vincent Gnanapragasam, Jorge Zamora, Sarah Thomas, Erik Mayer, Thierry Voet, S. Edwards, Peter J. Campbell, Stephen J. Gamble, Cathy Corbishley, Steven Hazell, Keiran Raine, Tim Dudderidge, Nimish Shah, Sarah O’Meara, David T. Jones, C. R. J. Woodhouse, Christopher S. Foster, Sue Merson, David C. Wedge, Lucy Stebbings, Nening Dennis, Alan Thompson
Publikováno v: Nature genetics, vol 47, iss 4
Nature genetics
© 2015 Nature America, Inc. All rights reserved.Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5b47a3e9612f7d159660895d16db9b
https://www.repository.cam.ac.uk/handle/1810/267175
Zobrazit plný text záznamu
8
Amplification and Overexpression of the KIT Gene Is Associated with Progression in the Seminoma Subtype of Testicular Germ Cell Tumors of Adolescents and Adults
Autor: Alan McIntyre, Leendert H. J. Looijenga, Ad J. M. Gillis, Nening Dennis, J. Wolter Oosterhuis, Robert Huddart, Ruud J.H.L.M. van Gurp, Jeremy Clark, Beata Grygalewicz, Cyril Fisher, Brenda Summersgill, Colin Cooper, Janet Shipley, J. Stoop
Publikováno v: Cancer Research. 65:8085-8089
We have previously identified amplification at 4q12 in testicular germ cell tumors of adolescents and adults centered around the KIT gene encoding a tyrosine kinase transmembrane receptor. Analysis of primary testicular germ cell tumors totaling 190
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd529819be854dad8cc7a30c4fc67c60
https://doi.org/10.1158/0008-5472.can-05-0471
Zobrazit plný text záznamu
9
Amplification and overexpression of E2F3 in human bladder cancer
Autor: Robert Huddart, Gyula Kovacs, Andrew Dodson, Richard Wooster, Jeremy Clark, Cyril Fisher, Penny Flohr, Toby Roe, Andrew Feber, Paul H. Smith, Nening Dennis, Graham H. Goodwin, Alison Falconer, Sandra L. Edwards, Colin Cooper, Christopher S. Foster, A Fletcher
Publikováno v: Oncogene. 23:1627-1630
We demonstrate that, in human bladder cancer, amplification of the E2F3 gene, located at 6p22, is associated with overexpression of its encoded mRNA transcripts and high levels of expression of E2F3 protein. Immunohistochemical analyses of E2F3 prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39eadb12b2040210b8dcbcfd11f1100
https://doi.org/10.1038/sj.onc.1207274
Zobrazit plný text záznamu
10
High-density tissue microarrays from prostate needle biopsies
Autor: Penny Flohr, Frank McCarthy, Chris Parker, Sameer Jhavar, Nening Dennis, Colin Cooper
Publikováno v: Journal of Clinical Pathology
Background Formalin-fixed prostate biopsies are frequently the only tissue collected at the time of prostate cancer diagnosis. There is therefore a requirement for techniques that allow the use of these prostate biopsy specimens in a high-throughput
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5519bd76c067f47e0a40d4a31f8dca
https://doi.org/10.1136/jcp.2010.082339
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje