Výsledky vyhledávání - "Nengqian Chen"

Purification and characterization of a new isozyme of thiol:protein-disulfide oxidoreductase from rat hepatic microsomes. Relationship of this isozyme to cytosolic phosphatidylinositol-specific phospholipase C form 1A

Autor: Jordan L. Holtzman, Nengqian Chen, Sri Prakash Srivastava, Yuxiu Liu

Publikováno v: Journal of Biological Chemistry. 266:20337-20344

Thiol:protein-disulfide oxidoreductase catalyzes the GSH reduction of protein disulfides to sulfhydryls. Chromatography of solubilized hepatic microsomes on Mono Q yielded two peaks, Q-2 and Q-5, which contained all the thiol:protein-disulfide oxidor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d7725c9ebe3f846cb94dfe91ecf4b55
https://doi.org/10.1016/s0021-9258(18)54928-0

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The in vitro NADPH-dependent inhibition by CCl4 of the ATP-dependent calcium uptake of hepatic microsomes from male rats. Studies on the mechanism of the inactivation of the hepatic microsomal calcium pump by the CCl3.radical

Autor: Nengqian Chen, S. P. Srivastava, J. L. Holtzman

Publikováno v: Journal of Biological Chemistry. 265:8392-8399

The hepatotoxicity of CCl4 is mediated through its initial reduction by cytochrome P-450 to the CCl3.radical. This radical then damages important metabolic systems such as the ATP-dependent microsomal Ca2+ pump. Previous studies from our laboratory o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::263865d19a12eacd046d10fb1caa20e2
https://doi.org/10.1016/s0021-9258(19)38899-4

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Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion

Autor: Nengqian Chen, Yasuhiro Tsuboi, Youngki Kim, Michael M. Paparella, Jizhen Lin, Steven K. Juhn, G. Scott Giebink, Patricia A. Schachern, Chap T. Le

Publikováno v: Acta oto-laryngologica. 122(2)

Otitis media with mucoid effusion, characterized by mucous cell metaplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a common otological disease that frequently affects young children. Multiple factors are invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6acd317593f7e85065283016b5e900
https://pubmed.ncbi.nlm.nih.gov/11936906

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The effect of substrates and inhibitors of cytochrome P-450 on the NADPH inhibition of the ATP-dependent, hepatic, microsomal calcium pump

Autor: Jordan L. Holtzman, Nengqian Chen, P. Srivastava

Publikováno v: FEBS Letters. (1-2):135-137

In hepatic microsomes one or more isozymes of cytochrome P-450 inhibits the ATP-dependent Ca2+ pump. This inhibition is reversible by GSH and appears to be due to a direct oxidation of the pump proteins by the oxygenated cytochrome. To determine whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baf8a69936997a76950462abfc7e683

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