Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nengneng, Cheng"'
Publikováno v:
Journal of Alzheimer's Disease. 87:873-886
Background: RE1-silencing transcription factor (REST) is known to silence target genes involved in synaptic plasticity and neuronal differentiation. Although previous studies implicate REST in neurodegenerative diseases, its function in the progressi
Autor:
Guoying Cao, Jufang Wu, Jinjie He, Jingjing Wang, Jicheng Yu, Basheng Zhang, Jiayan Lu, Jing Zhang, Shangzhi Chen, Xiaojie Wu, Nengneng Cheng
Publikováno v:
Clinical Drug Investigation. 41:89-97
Tegoprazan is one of the potassium-competitive acid blockers (P-CABs). It exhibits its anti-secretory effects by competitively and reversibly blocking the availability of K+ of the H+, K+-ATPase. This study was designed to investigate the safety and
Publikováno v:
Xenobiotica. 50:670-676
This study aimed to observe the influence of Sophora flavescens alcohol extract (SFAE) on hepatic metabolic profiling in rats to explore the possible mechanism of hepatotoxicity induced by S. flave...
Autor:
Qi Xiangyu, Huiti Li, Tingbo Ding, Jibin Dong, Chen Yan, Min Wei, Shuang Hu, Yang Cao, Nengneng Cheng, Li Yali, Mo Mingguang, Bin Lou, Deyong Ye, Yong Chu, Xiaoxia Li, Xian-Cheng Jiang, Taomin Huang, Lu Zhou
Publikováno v:
European Journal of Medicinal Chemistry. 163:864-882
The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxyben
Publikováno v:
Molecules, Vol 22, Iss 11, p 1809 (2017)
Our previous study showed that kurarinone was the main hepatotoxic ingredient of Sophora flavescens, accumulating in the liver. This study characterized the mechanism of Sophora flavescens extract (ESF) hepatotoxicity and hepatic accumulation of kura
Externí odkaz:
https://doaj.org/article/fef560ef6040469dba0acb276c441721
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(6)
This study aimed to observe the influence of
Autor:
Yutong, Huang, Taoming, Huang, Xiaonuo, Zhen, Yali, Li, Mingguang, Mo, Deyong, Ye, Nengneng, Cheng
Publikováno v:
Die Pharmazie. 74(9)
Insulin resistance is a typical precursor and primary feature of type 2 diabetes mellitus (T2DM). Sphingomyelin (SM) is a kind of sphingolipid located in animal brain, liver, kidney and muscle. Sphingomyelin synthase 2 (SMS2) is the key enzyme in the
Autor:
Jiahong Yang, Dadui Ren, Xuemei Zhang, Jing Zhang, Hong Xin, Nengneng Cheng, Yingxue Li, Junqiu Liu, Jia Luo
Publikováno v:
Phytomedicine. 67:153163
Background Renal interstitial fibrosis is a common pathway through which chronic kidney disease progresses to end-stage renal disease. There are currently no effective drugs available to treat kidney fibrosis, so traditional medicine is likely to be
Autor:
Wenxin Yao, Li Ling, Xiaoxia Li, Nengneng Cheng, Zhiqing Pang, Jingjing Zhao, Bo Zhang, Peicheng Xu
Publikováno v:
Journal of Colloid and Interface Science. 458:14-21
Long term retention of antimicrobials with effective drug concentration in gingival crevicular fluid (GCF) is of vital importance for the treatment of chronic periodontitis. In this study, a novel epithelial cell-targeting nanoparticle drug delivery
Publikováno v:
Pharmaceutical Biology. 54:619-627
Kurarinone, the most abundant prenylated flavonoid in Sophora flavescens Aiton (Leguminosae), is a promising antitumor therapeutic. However, it shows significant hepatotoxicity. Furthermore, how kurarinone is metabolized in humans remains unclear.The