Výsledky vyhledávání - "Neng-Bin Xie"

Bisulfite-Free and Single-Base Resolution Detection of Epigenetic DNA Modification of 5-Methylcytosine by Methyltransferase-Directed Labeling with APOBEC3A Deamination Sequencing

Autor: Jun Xiong, Ke-Ke Chen, Neng-Bin Xie, Tong-Tong Ji, Si-Yu Yu, Feng Tang, Conghua Xie, Yu-Qi Feng, Bi-Feng Yuan

Publikováno v: Analytical Chemistry. 94:15489-15498

DNA methylation (5-methylcytosine, 5mC) is the most prevalent epigenetic modification that is predominantly found in CG dinucleotides in mammalian genomes. In-depth investigation of the functions of 5mC heavily relies on the quantitative measurement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d604da30a6bd493b75b665f7d71f8018
https://doi.org/10.1021/acs.analchem.2c03808

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Single-Base Resolution Detection of Adenosine-to-Inosine RNA Editing by Endonuclease-Mediated Sequencing

Autor: Juan-Juan Chen, Xue-Jiao You, Lin Li, Neng-Bin Xie, Jiang-Hui Ding, Bi-Feng Yuan, Yu-Qi Feng

Publikováno v: Analytical Chemistry. 94:8740-8747

RNA molecules contain diverse modifications that play crucial roles in a wide variety of biological processes. Adenosine-to-inosine (A-to-Ino) RNA editing is one of the most prevalent modifications among all types of RNA. Abnormal A-to-InoRNA editing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c29ae54ce6bb1dd905f896fef9d8e7d
https://doi.org/10.1021/acs.analchem.2c01226

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Bisulfite-free and single-nucleotide resolution sequencing of DNA epigenetic modification of 5-hydroxymethylcytosine using engineered deaminase

Autor: Neng-Bin Xie, Min Wang, Tong-Tong Ji, Xia Guo, Jiang-Hui Ding, Bi-Feng Yuan, Yu-Qi Feng

Publikováno v: Chemical Science. 13:7046-7056

The discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes is a landmark in epigenomics study. Similar to 5-methylcytosine (5mC), 5hmC is viewed as a critical epigenetic modification. Deciphering the functions of 5hmC necessitates the locat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166c85aec80b064926eda975234d2b2a
https://doi.org/10.1039/d2sc01052f

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Engineered APOBEC3C Sequencing Enables Bisulfite-Free and Direct Detection of DNA Methylation at a Single-Base Resolution

Autor: Min Wang, Neng-Bin Xie, Ke-Ke Chen, Tong-Tong Ji, Jun Xiong, Xia Guo, Si-Yu Yu, Feng Tang, Conghua Xie, Yu-Qi Feng, Bi-Feng Yuan

Publikováno v: Analytical chemistry.

DNA methylation (5-methylcytosine, 5mC) is the most important epigenetic modification in mammals. Deciphering the roles of 5mC relies on the quantitative detection of 5mC at the single-base resolution. Bisulfite sequencing (BS-seq) is the most often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f06f5ea7be2e9702081c15963a4329f
https://pubmed.ncbi.nlm.nih.gov/36563112

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Quantitative and site-specific detection of inosine modification in RNA by acrylonitrile labeling-mediated elongation stalling

Autor: Jiang-Hui Ding, Meng-Yuan Chen, Neng-Bin Xie, Conghua Xie, Nanxiang Xiong, Jin-Gang He, Jie Wang, Cheng Guo, Yu-Qi Feng, Bi-Feng Yuan

Publikováno v: Biosensorsbioelectronics. 219

RNA molecules contain diverse modifications that play crucial roles in a wide variety of biological processes. Inosine is one of the most prevalent modifications in RNA and dysregulation of inosine is correlated with many human diseases. Herein, we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5270d60adba05f98d20c56081deb35f2
https://pubmed.ncbi.nlm.nih.gov/36279821

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Transformation of 5-Carboxylcytosine to Cytosine Through C–C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation

Autor: Cheng-Jie Ma, Xiang Zhou, Xiaoxue Zhang, Jiang-Hui Ding, Yang Feng, Yu-Qi Feng, Chengqi Yi, Bi-Feng Yuan, Neng-Bin Xie, Xue-Jiao You, Wan-Bing Tao

Publikováno v: CCS Chemistry. 3:994-1008

Active demethylation of 5-methylcytosine (5mC) can be realized through ten-eleven translocation (TET) dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC)...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c90ae95cd92d9422dec75a3d3fa9629
https://doi.org/10.31635/ccschem.020.202000286

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