Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Neng Wei Hu"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S468- (2023)
Externí odkaz:
https://doaj.org/article/c709913c8a354b019978a781523ad2e2
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S436- (2023)
Externí odkaz:
https://doaj.org/article/23fb9eabd88e4467bbd7dcae53843003
Autor:
Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei Hu
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 6, Pp 1213-1219 (2023)
Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus. Recent evidence i
Externí odkaz:
https://doaj.org/article/0a9ffba41e18447cbef73f89a346a903
Autor:
Zhengtao Hu, Pengpeng Yu, Yangyang Zhang, Yin Yang, Manyi Zhu, Shuangying Qin, Ji-Tian Xu, Dongxiao Duan, Yong Wu, Deguo Wang, Michael J. Rowan, Neng-Wei Hu
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated stress response (ISR) via multiple pathologies including neuronal hyperactivation, microvascular hypoxia, and neuroinflammation. Increasing eIF2α pho
Externí odkaz:
https://doaj.org/article/800bf20ce0ae46ac9292771104346e06
Autor:
Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T. Corbett, Graham Fraser, Michael S. Perkinton, Dominic M. Walsh, Andrew Billinton, Michael J. Rowan
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 582-590 (2019)
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid β-protein (Aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechani
Externí odkaz:
https://doaj.org/article/ff95f3803853489a8ff9a0588ee8803a
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2053-2065 (2018)
Summary: Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively non-specific
Externí odkaz:
https://doaj.org/article/db63ff2ac5b94a9bbb1113ccfef06acf
Autor:
Yangyang, Zhang, Yin, Yang, Zhengtao, Hu, Manyi, Zhu, Shuangying, Qin, Pengpeng, Yu, Bo, Li, Jitian, Xu, Tomas, Ondrejcak, Igor, Klyubin, Michael J, Rowan, Neng-Wei, Hu
Publikováno v:
Journal of Alzheimer's Disease. 89:335-350
Background: Cognitive decline in Alzheimer’s disease (AD) correlates with the extent of tau pathology, in particular tau hyperphosphorylation, which is strongly age-associated. Although elevation of cerebrospinal fluid or blood levels of phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca018623833782f9ebc426179af0644
https://doi.org/10.3233/jad-220351
https://doi.org/10.3233/jad-220351
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
How endogenously produced soluble amyloid ß-protein (Aß) affects synaptic plasticity in vulnerable circuits should provide insight into early Alzheimer’s disease pathophysiology. McGill-R-Thy1-APP transgenic rats, modeling Alzheimer’s disease a
Externí odkaz:
https://doaj.org/article/af9f4d8afc5844dc879ec920be994be1
Autor:
Yin Yang, Tomas Ondrejcak, Neng-Wei Hu, Sadia Islam, Eugene O'Rourke, Richard Reilly, Colm Cunningham, Michael Rowan, Igor Klyubin
Non-invasive sensory stimulation in the range of the brain’s gamma rhythm (30-100 Hz) is emerging as a new potential therapeutic strategy for the treatment of Alzheimer’s disease (AD). Here we investigated the effect of repeated combined exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e36c3af72c048cc362843dc9e063f0db
https://doi.org/10.22541/au.167565800.07181637/v1
https://doi.org/10.22541/au.167565800.07181637/v1
Autor:
Ondrejcak, Tomas, Klyubin, Igor, Neng-Wei Hu, O'Malley, Tiernan T., Corbett, Grant T., Winters, Róisín, Perkinton, Michael S., Billinton, Andy, Prenderville, Jack A., Walsh, Dominic M., Rowan, Michael J.
Publikováno v:
Journal of Neuroscience; 8/9/2023, Vol. 43 Issue 32, p5870-5879, 10p