Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Neng Lv"'
Generation of Nonhuman Primate Model of Cone Dysfunction through In Situ AAV-Mediated CNGB3 Ablation
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 869-879 (2020)
Summary: A major challenge to the development of therapies for human retinal degenerative diseases is the lack of an ideal preclinical model because of the physiological differences between humans and most model animals. Despite the successful genera
Externí odkaz:
https://doaj.org/article/571d939e02fd463f818f67aa04f3fe52
Autor:
Kun-Chao Wu, Ji-Neng Lv, Hui Yang, Feng-Mei Yang, Rui Lin, Qiang Lin, Ren-Juan Shen, Jun-Bin Wang, Wen-Hua Duan, Min Hu, Jun Zhang, Zhan-Long He, Zi-Bing Jin
Publikováno v:
Research, Vol 2020 (2020)
Human visual acuity is anatomically determined by the retinal fovea. The ontogenetic development of the fovea can be seriously hindered by oculocutaneous albinism (OCA), which is characterized by a disorder of melanin synthesis. Although people of al
Externí odkaz:
https://doaj.org/article/730fd131296948a2b6604765885fffed
Autor:
Wen-Li Deng, Mei-Ling Gao, Xin-Lan Lei, Ji-Neng Lv, Huan Zhao, Kai-Wen He, Xi-Xi Xia, Ling-Yun Li, Yu-Chen Chen, Yan-Ping Li, Deng Pan, Tian Xue, Zi-Bing Jin
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1267-1281 (2018)
Summary: Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the most common causes of this disease. Here, we generated induced p
Externí odkaz:
https://doaj.org/article/057a39d2e177461b8b7b95cf6cd7f0f7
Publikováno v:
Chemosphere.
Knowledge of the fate and transport of nanoscale zero-valent iron (nZVI) in saturated porous media is crucial to the development of in situ remediation technologies. This work systematically compared the retention and transport of carboxymethyl cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adda13e6b5bd8b02317d4f6bd0d84694
https://pubmed.ncbi.nlm.nih.gov/36495971
https://pubmed.ncbi.nlm.nih.gov/36495971
Generation of Nonhuman Primate Model of Cone Dysfunction through In Situ AAV-Mediated CNGB3 Ablation
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 869-879 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 869-879 (2020)
Summary A major challenge to the development of therapies for human retinal degenerative diseases is the lack of an ideal preclinical model because of the physiological differences between humans and most model animals. Despite the successful generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93322c83c910b48d77fbb9b1e9d8857d
http://europepmc.org/articles/PMC7479327
http://europepmc.org/articles/PMC7479327
Autor:
Lue Xiang, Ji-Neng Lv, Jia Qu, Zi-Bing Jin, Kun-Chao Wu, Xiao Zhang, Jie Chen, Xiu-Feng Huang, Deng Pan, Guang-Hui Jin, Xue-Bi Cai, Fan Lu, Bin Lu
Publikováno v:
Clinical Genetics. 96:61-71
Adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) protein participates in a broad range of cellular processes and acts as a mediator for mutant ARL2BP in cilium-associated retinitis pigmentosa and for mutant HRG4 in mitochondria-related p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d822efc5ac2e35bb806359d8cc6b797f
https://doi.org/10.1111/cge.13541
https://doi.org/10.1111/cge.13541
Autor:
Ji-Neng Lv, Feng Gu, Jinsong Li, Xiaoyu Liu, Junhao Fu, Tianxiang Tu, Jia Qu, Zongming Song, Qing Li, Xiujuan Lv, Jinwei Zhang, Xidi Yin
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Adenine base editors (ABE) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. However, the low activity of ABE at certain sites remains a major bottleneck that precludes efficacious applications. Here, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae642dbc4e3aab5bd860f2215d188ad0
https://pubmed.ncbi.nlm.nih.gov/34625552
https://pubmed.ncbi.nlm.nih.gov/34625552
Autor:
Zongming Song, Xiexie Liu, Ji-Neng Lv, Xiaoyu Liu, Junzhao Zhao, Haihua Xie, Chenchen Zhou, Yuanyuan Liu, Bang Wang, Xiubin He, Yong Liu, Xiujuan Lv, Mingchun Li, Feng Gu, Lianchao Tang, Changbao Liu
Publikováno v:
The Journal of Biological Chemistry
Clustered regularly interspaced short palindromic repeat–Cas12a has been harnessed to manipulate the human genome; however, low cleavage efficiency and stringent protospacer adjacent motif hinder the use of Cas12a-based therapy and applications. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7595f67ca5aefcb1841f84fec2c1f167
http://europepmc.org/articles/PMC7961096
http://europepmc.org/articles/PMC7961096
Autor:
Lue, Xiang, Juan, Zhang, Feng-Qin, Rao, Qiao-Li, Yang, Hui-Yi, Zeng, Sheng-Hai, Huang, Zhen-Xiang, Xie, Ji-Neng, Lv, Dan, Lin, Xue-Jiao, Chen, Kun-Chao, Wu, Fan, Lu, Xiu-Feng, Huang, Qi, Chen
Publikováno v:
Investigative Opthalmology & Visual Science. 63:24
Abundant retinal microRNA-183 cluster (miR-183C) has been reported to be a key player in photoreceptor development and functionality in mice. However, whether there is a protagonist in this cluster remains unclear. Here, we used a mutant mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f3168523e7b45d83cc62666a5eb111
https://doi.org/10.1167/iovs.63.4.24
https://doi.org/10.1167/iovs.63.4.24
Publikováno v:
Journal of hazardous materials. 396
Non-reducible solution anions have been well recognized to affect reactivity of ZVI in dechlorinating chlorinated hydrocarbons. However, their effects and corresponding functional mechanisms on electron efficiency (ee) of ZVI remain unclear. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca540d385240253e6c7d2d930f263bf1
https://pubmed.ncbi.nlm.nih.gov/32315940
https://pubmed.ncbi.nlm.nih.gov/32315940