Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Nenad, Sestan"'
Autor:
Lee T. Kissel, Sirisha Pochareddy, Joon-Yong An, Nenad Sestan, Stephan J. Sanders, Xuran Wang, Donna M. Werling
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 4, Pp 100321- (2024)
Background: Sex-differential biology may contribute to the consistently male-biased prevalence of autism spectrum disorder (ASD). Gene expression differences between males and females in the brain can indicate possible molecular and cellular mechanis
Externí odkaz:
https://doaj.org/article/d733114370664bbfa9b5ddbb8c72e4f3
Autor:
McKinzie A. Garrison, Yeongjun Jang, Taejeong Bae, Adriana Cherskov, Sarah B. Emery, Liana Fasching, Attila Jones, John B. Moldovan, Cindy Molitor, Sirisha Pochareddy, Mette A. Peters, Joo Heon Shin, Yifan Wang, Xiaoxu Yang, Schahram Akbarian, Andrew Chess, Fred H. Gage, Joseph G. Gleeson, Jeffrey M. Kidd, Michael McConnell, Ryan E. Mills, John V. Moran, Peter J. Park, Nenad Sestan, Alexander E. Urban, Flora M. Vaccarino, Christopher A. Walsh, Daniel R. Weinberger, Sarah J. Wheelan, Alexej Abyzov, BSMN Consortium
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-18 (2023)
Abstract Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that p
Externí odkaz:
https://doaj.org/article/169288af9ac84d8b8a7875b0a5f4336c
Autor:
Anthony G. Boghdadi, Joshua Spurrier, Leon Teo, Mingfeng Li, Mario Skarica, Benjamin Cao, William C. Kwan, Tobias D. Merson, Susan K. Nilsson, Nenad Sestan, Stephen M. Strittmatter, James A. Bourne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Astrocytes are important players in ischemic stroke. Here, the authors use single nuclei transcriptomics to characterise marmoset astrocytes following brain injury. At functional level, they show that NogoAexpressing astrocytes limit macrophage infil
Externí odkaz:
https://doaj.org/article/7d7d2c9ecae3430ebc0d5c40de26ce6f
Autor:
Lindsay Liang, Siavash Fazel Darbandi, Sirisha Pochareddy, Forrest O. Gulden, Michael C. Gilson, Brooke K. Sheppard, Atehsa Sahagun, Joon-Yong An, Donna M. Werling, John L. R. Rubenstein, Nenad Sestan, Kevin J. Bender, Stephan J. Sanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across devel
Externí odkaz:
https://doaj.org/article/7348d7aab02f4d87839686b6a126df57
Autor:
Benxia Hu, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A. Crowley, Sirisha Pochareddy, The PsychENCODE Consortium, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H. Geschwind
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to ch
Externí odkaz:
https://doaj.org/article/58d534607fbd40f0b3a815f520ae49df
Autor:
Lori Glenwinkel, Seth R Taylor, Kasper Langebeck-Jensen, Laura Pereira, Molly B Reilly, Manasa Basavaraju, Ibnul Rafi, Eviatar Yemini, Roger Pocock, Nenad Sestan, Marc Hammarlund, David M Miller III, Oliver Hobert
Publikováno v:
eLife, Vol 10 (2021)
The generation of the enormous diversity of neuronal cell types in a differentiating nervous system entails the activation of neuron type-specific gene batteries. To examine the regulatory logic that controls the expression of neuron type-specific ge
Externí odkaz:
https://doaj.org/article/af7e725ca0754a56a5647a1273beb41c
Autor:
Nicola Micali, Suel-Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O’Brien, Seungmae Seo, Joo-Heon Shin, Brian G. Rash, Shaojie Ma, Yanhong Wang, Nicolas A. Olivares, Jon I. Arellano, Kristen R. Maynard, Elana J. Fertig, Alan J. Cross, Roland W. Bürli, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad Sestan, Pasko Rakic, Carlo Colantuoni, Ronald D. McKay
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imagi
Externí odkaz:
https://doaj.org/article/09028c601a8b4575b9d6ec90dadc6fb0
Autor:
Donna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon-Yong An, Brooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, André M.M. Sousa, Andrew T.N. Tebbenkamp, Navjot Kaur, Forrest O. Gulden, Michael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, Lambertus Klei, A. Ercument Cicek, Joseph D. Buxbaum, Homa Adle-Biassette, Jean-Leon Thomas, Kimberly A. Aldinger, Diana R. O’Day, Ian A. Glass, Noah A. Zaitlen, Michael E. Talkowski, Kathryn Roeder, Matthew W. State, Bernie Devlin, Stephan J. Sanders, Nenad Sestan
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to the variation in expression, and some neuropsychiatric disorder loci may exert their effects through this mechani
Externí odkaz:
https://doaj.org/article/659cb161cbb744e39a67fefdafb36d56
Autor:
Maria Teresa Dell’Anno, Xingxing Wang, Marco Onorati, Mingfeng Li, Francesca Talpo, Yuichi Sekine, Shaojie Ma, Fuchen Liu, William B. J. Cafferty, Nenad Sestan, Stephen M. Strittmatter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The optimal type or regional origin of stem cells for regenerative applications in the nervous system has not yet been established. Here the authors show that human neuroepithelial stem cells from the developing spinal cord, but not those from the de
Externí odkaz:
https://doaj.org/article/0c6bf4dc8dc74542a0664aa648168a87
Autor:
Phan Q Duy, Pasko Rakic, Seth L Alper, Stephanie M Robert, Adam J Kundishora, William E Butler, Christopher A Walsh, Nenad Sestan, Daniel H Geschwind, Sheng Chih Jin, Kristopher T Kahle
Publikováno v:
Cerebral Cortex. 33:4262-4279
Pediatric hydrocephalus, the leading reason for brain surgery in children, is characterized by enlargement of the cerebral ventricles classically attributed to cerebrospinal fluid (CSF) overaccumulation. Neurosurgical shunting to reduce CSF volume is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36856f552f08ff977d2e115522751d35
https://doi.org/10.1093/cercor/bhac341
https://doi.org/10.1093/cercor/bhac341