Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nen Saito"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Bow-tie architecture is a layered network structure that has a narrow middle layer with multiple inputs and outputs. Such structures are widely seen in the molecular networks in cells, suggesting that a universal evolutionary mechanism under
Externí odkaz:
https://doaj.org/article/ce1a3bf16fd34ab48d237f11c99ea77a
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Shape measurements are crucial for evolutionary and developmental biology; however, they present difficulties in the objective and automatic quantification of arbitrary shapes. Conventional approaches are based on anatomically prominent land
Externí odkaz:
https://doaj.org/article/af5f44ce80334a92bd32e55feb351f27
Autor:
Yudai Hatakeyama, Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto, Honda Naoki, Shinji Takada
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Neuromesodermal progenitor (NMP) cells produce and receive Wnt ligands. Here, the authors show that mutual intercellular exchange of Wnt ligands reduces heterogeneity between NMP cells and makes NMP populations robust to environmental stress.
Externí odkaz:
https://doaj.org/article/dbf569909e2848698b13c9d176e72f9c
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1011034 (2023)
The genetic code refers to a rule that maps 64 codons to 20 amino acids. Nearly all organisms, with few exceptions, share the same genetic code, the standard genetic code (SGC). While it remains unclear why this universal code has arisen and been mai
Externí odkaz:
https://doaj.org/article/a105ba71fb644036b3181af699082eed
Autor:
Nen Saito, Satoshi Sawai
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103087- (2021)
Summary: Macropinocytosis refers to the non-specific uptake of extracellular fluid, which plays ubiquitous roles in cell growth, immune surveillance, and virus entry. Despite its widespread occurrence, it remains unclear how its initial cup-shaped pl
Externí odkaz:
https://doaj.org/article/f367cd6ce583496399c1144977293471
Autor:
Daisuke Imoto, Nen Saito, Akihiko Nakajima, Gen Honda, Motohiko Ishida, Toyoko Sugita, Sayaka Ishihara, Koko Katagiri, Chika Okimura, Yoshiaki Iwadate, Satoshi Sawai
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009237 (2021)
Navigation of fast migrating cells such as amoeba Dictyostelium and immune cells are tightly associated with their morphologies that range from steady polarized forms that support high directionality to those more complex and variable when making fre
Externí odkaz:
https://doaj.org/article/209d54d962e84374aebd4258c6fc93b1
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009143 (2021)
Microbial communities display remarkable diversity, facilitated by the secretion of chemicals that can create new niches. However, it is unclear why cells often secrete even essential metabolites after evolution. Based on theoretical results indicati
Externí odkaz:
https://doaj.org/article/a4714773773844a88cfbd6fbbfbc709e
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 10, p e1005042 (2016)
As cells grow and divide under a given environment, they become crowded and resources are limited, as seen in bacterial biofilms and multicellular aggregates. These cells often show strong interactions through exchanging chemicals, as evident in quor
Externí odkaz:
https://doaj.org/article/31924458ee6c46d7afa52e873e3284c1
Publikováno v:
New Journal of Physics, Vol 16, Iss 6, p 063013 (2014)
Despite its ubiquity among organisms, genetic redundancy is presumed to reduce total population fitness and is therefore unlikely to evolve. This study evaluates an evolutionary model with high-dimensional genotype–phenotype mapping (GPM) by applyi
Externí odkaz:
https://doaj.org/article/9e24c175d42d47248d39edc1b477bc9d
Autor:
Nen Saito, Macoto Kikuchi
Publikováno v:
New Journal of Physics, Vol 15, Iss 5, p 053037 (2013)
Dynamics in biological networks are, in general, robust against several perturbations. We investigate a coupled map network as a model motivated by gene regulatory networks and design systems that are robust against phenotypic perturbations (perturba
Externí odkaz:
https://doaj.org/article/003ad5675cc545f4b79476c3153d584d