Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Nemes Mm"'
Publikováno v:
The Journal of General Physiology
A discussion of factors considered influential in making a polynucleotide an efficient inducer of interferon was presented. These factors were double-strandedness of the polynucleotides, the sugar moiety of the polynucleotides, thermal stability, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93535de1d5811aa8e21697e4e267c722
https://pubmed.ncbi.nlm.nih.gov/19873677
https://pubmed.ncbi.nlm.nih.gov/19873677
Publikováno v:
Experimental Biology and Medicine. 135:911-916
SummaryPreparations of high molecular weight rIn:rCn were exposed to sonic radiation. A decrease in the average molecular weight of the polynucleotide complexes after treatment was accompanied by an exponential decrease in viscosity of the preparatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad6650187ff4098aeba6a995d746b25
https://doi.org/10.3181/00379727-135-35169
https://doi.org/10.3181/00379727-135-35169
Publikováno v:
Experimental Biology and Medicine. 132:776-783
SummaryStudies were conducted in mice and chicks to measure the prophylactic and therapeutic efficacy of poly I:C in a variety of infections by both DNA and RNA viruses. Drug and virus were given by a variety of routes in a number of different regime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc5522a90243e38166f87cc362aaaac
https://doi.org/10.3181/00379727-132-34308
https://doi.org/10.3181/00379727-132-34308
Publikováno v:
Experimental Biology and Medicine. 132:212-218
SummaryCertain basic polyamines, such as neomycin, neamine, kanamycin, streptomycin, and spermine, added to poly I:C increased the Tm. The degree of termal stabilization was influenced by the molecular ratio of polyamine to poly I:C and by the ionic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed51df0592ddc85dbe098cefd8532b4d
https://doi.org/10.3181/00379727-132-34182
https://doi.org/10.3181/00379727-132-34182
Autor:
Maurice R. Hilleman, Nemes Mm
Publikováno v:
Experimental Biology and Medicine. 110:500-504
SummaryWestphal's lipid A assayed in mice and hamsters enhanced non-specific host resistance against the activities of viruses such as was demonstrated earlier for bacterial endotoxins and for other materials of microbial origin. Lipid A, given intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008fbbe8717dbb1758719eefa98abc60
https://doi.org/10.3181/00379727-110-27563
https://doi.org/10.3181/00379727-110-27563
Publikováno v:
Experimental Biology and Medicine. 112:468-478
SummaryChick embryo interferon was purified from allantoic fluid of embryonated eggs infected with influenza A virus. Purification consisted essentially of acid precipitation to remove virus and extraneous protein, concentration and purification by p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61587ac620318231794aa89a1fcabbdc
https://doi.org/10.3181/00379727-112-28080
https://doi.org/10.3181/00379727-112-28080
Publikováno v:
Experimental Biology and Medicine. 141:1068-1072
SummaryAppropriate reduction in size of poly C by degradation with ribonuclease prior to complexing with poly I effected marked reduction in toxicity for mice and antigenicity for rabbits of poly I:C without detectable reduction in in vivo or in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7eee9300cd142392a550f830fbfbb23
https://doi.org/10.3181/00379727-141-36934
https://doi.org/10.3181/00379727-141-36934
Sinee interferon1 per se shows little promise as a prophvlactic or therapeutic ageuit, interest has shifted to a search for acceptable inducers by which the body might be stimulated to make its own interferon. Shope2 demonstrated that a substance whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c595cdec5273ad92cb92dd21cbdb16c
https://europepmc.org/articles/PMC335701/
https://europepmc.org/articles/PMC335701/
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 132(2)
SummaryStudies in cell cultures, rabbits, and mice demonstrated the prophylactic and therapeutic efficacy against viral infections and of interferon induction by a variety of double-stranded RNA's of natural origin including fungi, animal, plant, ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0912cb474e1e54cae97fe92004a829ca
https://pubmed.ncbi.nlm.nih.gov/4311212
https://pubmed.ncbi.nlm.nih.gov/4311212
Autor:
Nemes Mm, Maurice R. Hilleman
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 119
SummaryA recently synthesized compound, 5-methylamino-2′-deoxyuridine (MADU) was shown to be highly active in suppressing infection with herpes simplex virus in vitro and to exert beneficial effect in therapeutic and prophylactic-therapeutic treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a883d585e0ce92df686a2505e0313a8
https://pubmed.ncbi.nlm.nih.gov/14328932
https://pubmed.ncbi.nlm.nih.gov/14328932