Impact of media supplements FGF2, LIF and IGF1 on the genome activity of porcine embryos produced in vitro

Autor: Alexandra Rosenbaum Bartkova, Lucie Nemcova, Frantisek Strejcek, Ahmed Gad, Veronika Kinterova, Martin Morovic, Michal Benc, Radek Prochazka, Jozef Laurincik

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract In this article, we focused on the impact of precisely chemically modified FLI maturation medium enriched with fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), insulin-like growth factor 1 (IGF1), and polyvinyl alcohol (P

Externí odkaz: https://doaj.org/article/0461f2912d654599bc10af92afd1e41f

A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition

Autor: Petra Zemankova, Marta Cerna, Klara Horackova, Corinna Ernst, Jana Soukupova, Marianna Borecka, Britta Blümcke, Leona Cerna, Monika Cerna, Vaclava Curtisova, Tatana Dolezalova, Petra Duskova, Lenka Dvorakova, Lenka Foretova, Ondrej Havranek, Jan Hauke, Eric Hahnen, Miloslava Hodulova, Milena Hovhannisyan, Lucie Hruskova, Marketa Janatova, Maria Janikova, Sandra Jelinkova, Pavel Just, Marcela Kosarova, Monika Koudova, Vera Krutilkova, Eva Machackova, Katerina Matejkova, Renata Michalovska, Adela Misove, Petr Nehasil, Barbora Nemcova, Jan Novotny, Ales Panczak, Pavel Pesek, Ondrej Scheinost, Drahomira Springer, Barbora Stastna, Viktor Stranecky, Ivan Subrt, Spiros Tavandzis, Eva Tureckova, Kamila Vesela, Zdenka Vlckova, Michal Vocka, Barbara Wappenschmidt, Tomas Zima, Zdenek Kleibl, Petra Kleiblova

Publikováno v: Breast, Vol 75, Iss , Pp 103721- (2024)

Germline CHEK2 pathogenic variants confer an increased risk of female breast cancer (FBC). Here we describe a recurrent germline intronic variant c.1009-118_1009-87delinsC, which showed a splice acceptor shift in RNA analysis, introducing a premature

Externí odkaz: https://doaj.org/article/550a6d19812d49439f776d55972c1a43

The Replication Database: Documenting the Replicability of Psychological Science

Autor: Lukas Röseler, Leonard Kaiser, Christopher Doetsch, Noah Klett, Christian Seida, Astrid Schütz, Balazs Aczel, Nadia Adelina, Valeria Agostini, Samuel Alarie, Nihan Albayrak-Aydemir, Alaa Aldoh, Ali H. Al-Hoorie, Flavio Azevedo, Bradley J. Baker, Charlotte Lilian Barth, Julia Beitner, Cameron Brick, Hilmar Brohmer, Subramanya Prasad Chandrashekar, Kai Li Chung, Jamie P. Cockcroft, Jamie Cummins, Veronica Diveica, Tsvetomira Dumbalska, Emir Efendic, Mahmoud Elsherif, Thomas Evans, Gilad Feldman, Adrien Fillon, Nico Förster, Joris Frese, Oliver Genschow, Vaitsa Giannouli, Biljana Gjoneska, Timo Gnambs, Amélie Gourdon-Kanhukamwe, Christopher J. Graham, Helena Hartmann, Clove Haviva, Alina Herderich, Leon P. Hilbert, Darías Holgado, Ian Hussey, Zlatomira G. Ilchovska, Tamara Kalandadze, Veli-Matti Karhulahti, Leon Kasseckert, Maren Klingelhöfer-Jens, Alina Koppold, Max Korbmacher, Louisa Kulke, Niclas Kuper, Annalise LaPlume, Gavin Leech, Feline Lohkamp, Nigel Mantou Lou, Dermot Lynott, Maximilian Maier, Maria Meier, Maria Montefinese, David Moreau, Kellen Mrkva, Monika Nemcova, Danna Oomen, Julian Packheiser, Shubham Pandey, Frank Papenmeier, Mariola Paruzel-Czachura, Yuri G. Pavlov, Zoran Pavlović, Charlotte R. Pennington, Merle-Marie Pittelkow, Willemijn Plomp, Paul E. Plonski, Ekaterina Pronizius, Andrew Adrian Pua, Katarzyna Pypno-Blajda, Manuel Rausch, Tobias R. Rebholz, Elena Richert, Jan Philipp Röer, Robert Ross, Kathleen Schmidt, Aleksandrina Skvortsova, Matthias F. J. Sperl, Alvin W. M. Tan, J. Lukas Thürmer, Aleksandra Tołopiło, Wolf Vanpaemel, Leigh Ann Vaughn, Steven Verheyen, Lukas Wallrich, Lucia Weber, Julia K. Wolska, Mirela Zaneva, Yikang Zhang

Publikováno v: Journal of Open Psychology Data, Vol 12, Iss 1, Pp 8-8 (2024)

In psychological science, replicability—repeating a study with a new sample achieving consistent results (Parsons et al., 2022)—is critical for affirming the validity of scientific findings. Despite its importance, replication efforts are few and

Externí odkaz: https://doaj.org/article/713c9840de3c483bbd141bbebbac950a

Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma

Autor: Tomas Sychra, Alzbeta Spalenkova, Stepan Balatka, Radka Vaclavikova, Karolina Seborova, Marie Ehrlichova, Jaroslav Truksa, Cristian Sandoval-Acuña, Vlasta Nemcova, Arpad Szabo, Kamila Koci, Tereza Tesarova, Lei Chen, Iwao Ojima, Martin Oliverius, Pavel Soucek

Publikováno v: iScience, Vol 27, Iss 2, Pp 109044- (2024)

Summary: Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most promising way to improv

Externí odkaz: https://doaj.org/article/a032fb8b23884f2993b71832d334ba03

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