Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids

Autor: Nemanichvili, Nikoloz, Spruit, Cindy M, Berends, Alinda J, Gröne, Andrea, Rijks, Jolianne M, Verheije, Monique H, de Vries, Robert P, Pharmacology, dPB I&I, Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Afd Pharmacology, dI&I I&I-1, VPDC pathologie, dPB CR

Publikováno v: Glycobiology, 32(9), 791. Oxford University Press

Sialic acids are used as a receptor by several viruses and variations in the linkage type or C-5 modifications affect the binding properties. A species barrier for multiple viruses is present due to α2,3- or α2,6-linked sialic acids. The C-5 positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22daed9ce13febb945bfd4c0277f7866
https://dspace.library.uu.nl/handle/1874/422489

Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals

Autor: Nemanichvili, Nikoloz, Berends, Alinda J, Wubbolts, Richard W, Gröne, Andrea, Rijks, Jolianne M, de Vries, Robert P, Verheije, Monique H, VP pathologie, dI&I I&I-1, dPB I&I, Celbiologie, IOV CCB, dB&C I&I, dPB CR, VPDC pathologie, Afd Chemical Biology and Drug Discovery, Pharmacology, Chemical Biology and Drug Discovery

Publikováno v: Viruses
Volume 13
Issue 4
Viruses, 13(4), 1. Multidisciplinary Digital Publishing Institute (MDPI)
Viruses, Vol 13, Iss 586, p 586 (2021)

The trimeric hemagglutinin-esterase fusion protein (HEF) of influenza D virus (IDV) binds 9-O-acetylated sialic acid receptors, which are expressed in various host species. While cattle are the main reservoir for IDV, the viral genome has also been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48b5c2433280efdd2a83da43ff6c13c
https://dspace.library.uu.nl/handle/1874/411840

Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties

Autor: Nemanichvili, Nikoloz, Tomris, Ilhan, Turner, Hannah L, McBride, Ryan, Grant, Oliver C, van der Woude, Roosmarijn, Aldosari, Mohammed H, Pieters, Roland J, Woods, Robert J, Paulson, James C, Boons, Geert-Jan, Ward, Andrew B, Verheije, Monique H, de Vries, Robert P, Chemical Biology and Drug Discovery, Pharmaceutics, dPB I&I, LS Pathologie, Afd Chemical Biology and Drug Discovery, Afd Pharmaceutics, Sub Chemical Biology and Drug Discovery

Publikováno v: Journal of Molecular Biology, 431(4), 842. Academic Press Inc.

Influenza A virus carries hundreds of trimeric hemagglutinin (HA) proteins on its viral envelope that interact with various sialylated glycans on a host cell. This interaction represents a multivalent binding event that is present in all the current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76036eaab094aa08c976ab806388ca
https://dspace.library.uu.nl/handle/1874/376022

Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids.

Autor: Nemanichvili N; Division of Pathology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands., Spruit CM; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands., Berends AJ; Division of Pathology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands., Gröne A; Division of Pathology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands., Rijks JM; Dutch Wildlife Health Centre, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands., Verheije MH; Division of Pathology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands., de Vries RP; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.

Publikováno v: Glycobiology [Glycobiology] 2022 Aug 18; Vol. 32 (9), pp. 791-802.

Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties.

Autor: Nemanichvili N; Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584, CL, Utrecht, the Netherlands., Tomris I; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands., Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., McBride R; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Immunology & Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Grant OC; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA 30602, USA., van der Woude R; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands., Aldosari MH; Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands; Drug sector, Saudi Food and Drug Authority, Riyadh, Saudi Arabia., Pieters RJ; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands., Woods RJ; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA 30602, USA., Paulson JC; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Immunology & Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Boons GJ; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands; Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA 30602, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Verheije MH; Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584, CL, Utrecht, the Netherlands. Electronic address: m.h.verheije@uu.nl., de Vries RP; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584, CG, Utrecht, the Netherlands. Electronic address: r.vries@uu.nl.

Publikováno v: Journal of molecular biology [J Mol Biol] 2019 Feb 15; Vol. 431 (4), pp. 842-856. Date of Electronic Publication: 2018 Dec 29.