17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.

Autor: Jakwerth CA; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Weckmann M; Member of the German Center for Lung Research (DZL), Germany.; Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany.; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Illi S; Member of the German Center for Lung Research (DZL), Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.; Comprehensive Pneumology Center-Munich, Munich, Germany., Charles H; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Zissler UM; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Oelsner M; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Guerth F; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Omony J; Member of the German Center for Lung Research (DZL), Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.; Comprehensive Pneumology Center-Munich, Munich, Germany., Nemani SSP; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Grychtol R; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany., Dittrich AM; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany., Skevaki C; Member of the German Center for Lung Research (DZL), Germany.; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics and., Foth S; Member of the German Center for Lung Research (DZL), Germany.; Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children's Hospital Marburg, University of Marburg, Marburg, Germany., Weber S; Member of the German Center for Lung Research (DZL), Germany.; Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children's Hospital Marburg, University of Marburg, Marburg, Germany., Alejandre Alcazar MA; Member of the German Center for Lung Research (DZL), Germany.; Institute for Lung Health and Cardio-Pulmonary Institute, Universities of Giessen and Marburg Lung Center, Giessen, Germany.; Translational Experimental Pediatrics, Experimental Pulmonology, Department of Pediatrics.; Center for Molecular Medicine Cologne and Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases, and.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., van Koningsbruggen-Rietschel S; Member of the German Center for Lung Research (DZL), Germany.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., Brock R; Member of the German Center for Lung Research (DZL), Germany.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., Blau S; Member of the German Center for Lung Research (DZL), Germany.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., Hansen G; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany.; Cluster of Excellence 2115 (RESIST), Hannover Medical School, Hanover, Germany., Bahmer T; Member of the German Center for Lung Research (DZL), Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany.; Internal Medicine Department I, University Hospital Schleswig-Holstein-Campus Kiel, Kiel, Germany., Rabe KF; Member of the German Center for Lung Research (DZL), Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany.; LungenClinic Grosshansdorf GmbH and Medical Clinics, Christian Albrechts University, Kiel, Germany., Brinkmann F; Member of the German Center for Lung Research (DZL), Germany.; Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany.; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Kopp MV; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Chaker AM; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany., Schaub B; Member of the German Center for Lung Research (DZL), Germany.; Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.; Comprehensive Pneumology Center-Munich, Munich, Germany., von Mutius E; Member of the German Center for Lung Research (DZL), Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.; Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Schmidt-Weber CB; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Apr 15; Vol. 209 (8), pp. 947-959.

COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding.

Autor: Nemani SSP; Division of Paediatric Pneumology and Allergology, University Medical Centre Schleswig-Holstein, Airway Research Centre North, member of the German Centre for Lung Research (DZL), Lübeck, Germany., Vermeulen CJ; Dept of Pulmonary Diseases, University Medical Centre Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, Groningen, The Netherlands., Pech M; Division of Paediatric Pneumology and Allergology, University Medical Centre Schleswig-Holstein, Airway Research Centre North, member of the German Centre for Lung Research (DZL), Lübeck, Germany., Faiz A; Dept of Pulmonary Diseases, University Medical Centre Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, Groningen, The Netherlands.; Dept of Pathology and Medical Biology, University Medical Centre Groningen, GRIAC, University of Groningen, Groningen, The Netherlands.; Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia.; School of Life Sciences, University of Technology, Sydney, NSW, Australia., Oliver BGG; Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia.; School of Life Sciences, University of Technology, Sydney, NSW, Australia., van den Berge M; Dept of Pulmonary Diseases, University Medical Centre Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, Groningen, The Netherlands., Burgess JK; Dept of Pathology and Medical Biology, University Medical Centre Groningen, GRIAC, University of Groningen, Groningen, The Netherlands.; Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia.; Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, NSW, Australia., Kopp MV; Division of Paediatric Pneumology and Allergology, University Medical Centre Schleswig-Holstein, Airway Research Centre North, member of the German Centre for Lung Research (DZL), Lübeck, Germany.; Pediatric Respiratory Medicine, Dept of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Weckmann M; Division of Paediatric Pneumology and Allergology, University Medical Centre Schleswig-Holstein, Airway Research Centre North, member of the German Centre for Lung Research (DZL), Lübeck, Germany.

Publikováno v: ERJ open research [ERJ Open Res] 2021 Jun 07; Vol. 7 (2). Date of Electronic Publication: 2021 Jun 07 (Print Publication: 2021).