Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Nelson Varela"'
Autor:
Angel T. Alvarado, Ana María Muñoz, Nelson Varela, Luis Sullón-Dextre, Mario Pineda, Mario Bolarte-Arteaga, María R. Bendezú, Jorge A. García, Haydee Chávez, Felipe Surco-Laos, Elizabeth J. Melgar-Merino, Pompeyo A. Cuba-Garcia, Aura Molina-Cabrera, Bertha Pari-Olarte, Mario Bonifaz-Hernandez, Juan F. Panay-Centeno, José Kong-Chirinos, José Almeida-Galindo
Publikováno v:
Pharmacia, Vol 70, Iss 3, Pp 603-618 (2023)
Epilepsy is the most common neurological disorder with a worldwide incidence of 20% and a treatment failure rate of 25–30%. The fluctuation in serum levels, efficacy and safety of antiepileptic drugs can be attributed to single nucleotide polymorph
Externí odkaz:
https://doaj.org/article/54ad39ba28e64d798a178479c1a537a4
Autor:
Andrés López-Cortés, Lavanya Prathap, Esteban Ortiz-Prado, Nikolaos C. Kyriakidis, Ángela León Cáceres, Isaac Armendáriz-Castillo, Antonella Vera-Guapi, Verónica Yumiceba, Katherine Simbaña-Rivera, Gabriela Echeverría-Garcés, Jennyfer M. García-Cárdenas, Andy Pérez-Villa, Patricia Guevara-Ramírez, Andrea Abad-Sojos, Jhommara Bautista, Lourdes Puig San Andrés, Nelson Varela, Santiago Guerrero
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access to nutrients due to poor vascularization in the tissue, phenomenon known as hypoxia. Hypoxic tumors are able to regulate the expression of certain gen
Externí odkaz:
https://doaj.org/article/232a46b4edde474ab4010ae0d3483ad3
Autor:
Angel T. Alvarado, Roberto Ybañez-Julca, Ana María Muñoz, César Tejada-Bechi, Roberto Cerro, Luis Abel Quiñones, Nelson Varela, César André Alvarado, Erick Alvarado, María R. Bendezú, Jorge A. García
Publikováno v:
Pharmacia, Vol 68, Iss 4, Pp 891-898 (2021)
Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 and 0.051 for CYP2D6*4. The percentages of genotypes described were 97% CYP2D
Externí odkaz:
https://doaj.org/article/9aa32c519b2544ad813c85c46e552922
Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population
Autor:
Angel Tito Alvarado, Ana María Muñoz, María Saravia Bartra, Milton Valderrama-Wong, Daniela González, Luis Abel Quiñones, Nelson Varela, María Rocío Bendezú, Jorge Antonio García, Berta Loja-Herrera
Publikováno v:
Pharmacia, Vol 68, Iss 4, Pp 747-754 (2021)
The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), resp
Externí odkaz:
https://doaj.org/article/4c7e3cda72634e93be5a9379aab2d789
Publikováno v:
Cirugía del Uruguay, Vol 34, Iss 5-6, Pp 337-341 (2020)
Presentado en sesión de 24 de julio de 1963
Externí odkaz:
https://doaj.org/article/2ad462784bbd43debfe8eff8f5644def
Publikováno v:
Cirugía del Uruguay, Vol 27, Iss 5, Pp 508-524 (2020)
Presentado en sesión de 12 de setiembre de 1956
Externí odkaz:
https://doaj.org/article/cc98fd2d762240958c8200d3d5730571
Autor:
Alfonso Santos Dubra, Nelson Varela
Publikováno v:
Cirugía del Uruguay, Vol 26, Iss 2, Pp 296-304 (2020)
Presentado en sesión de 27 de julio de 1955
Externí odkaz:
https://doaj.org/article/69b4cf8599c147df80ab7a3bcd11780f
Publikováno v:
Cirugía del Uruguay, Vol 22, Iss 1, Pp 102-107 (2020)
Presentado en sesión de 6 de junio de 1951
Externí odkaz:
https://doaj.org/article/c521ab79159c450481213fe4acc3caf8
Autor:
Stephania Contreras-Castillo, Anita Plaza, Jana Stojanova, Gustavo Navarro, Rodolfo Carmona, Fernando Corvalán, Leslie Cerpa, Christopher Sandoval, Daniel Muñoz, Marina Leiva, Luis E. Castañeda, Nayaret Farias, Carolina Alvarez, Gabriel Llull, Sergio Mezzano, Leopoldo Ardiles, Nelson Varela, María S. Rodríguez, Claudio Flores, Juan Pablo Cayún, Paola Krall, Luis A. Quiñones
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and transport of these drugs, namely
Externí odkaz:
https://doaj.org/article/c28dddbae4df42c68dc8fa4a41bc383e
Autor:
Andrés López-Cortés, Patricia Guevara-Ramírez, Nikolaos C. Kyriakidis, Carlos Barba-Ostria, Ángela León Cáceres, Santiago Guerrero, Esteban Ortiz-Prado, Cristian R. Munteanu, Eduardo Tejera, Doménica Cevallos-Robalino, Ana María Gómez-Jaramillo, Katherine Simbaña-Rivera, Adriana Granizo-Martínez, Gabriela Pérez-M, Silvana Moreno, Jennyfer M. García-Cárdenas, Ana Karina Zambrano, Yunierkis Pérez-Castillo, Alejandro Cabrera-Andrade, Lourdes Puig San Andrés, Carolina Proaño-Castro, Jhommara Bautista, Andreina Quevedo, Nelson Varela, Luis Abel Quiñones, César Paz-y-Miño
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively.Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of hum
Externí odkaz:
https://doaj.org/article/12ff2b56580a4125942a16060c739b52