Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Nelson Ruiz-Opazo"'
Autor:
Victoria L. M. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, David B. Seder, Nelson Ruiz-Opazo, Allan J. Walkey
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Background Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutrophil/NETs-mediated prog
Externí odkaz:
https://doaj.org/article/bfd51311bea44c489d92e19eed9b0408
Autor:
Victoria L. M. Herrera, Christopher M. Gromisch, Julius L. Decano, Khristine Amber Pasion, Glaiza L. A. Tan, Ning Hua, Courtney E. Takahashi, David M. Greer, Nelson Ruiz-Opazo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Progressive secondary brain injury—induced by dysregulated neuroinflammation in spontaneous intracerebral hemorrhage (sICH)—underlies high sICH-mortality and remains without FDA-approved pharmacotherapy. Clinical insight that hematoma-di
Externí odkaz:
https://doaj.org/article/33396bd56af74fc98fcb9f472609131a
Autor:
Victoria L. M. Herrera, Allan J. Walkey, Mai Q. Nguyen, Christopher M. Gromisch, Julie Z. Mosaddhegi, Matthew S. Gromisch, Bakr Jundi, Soeren Lukassen, Saskia Carstensen, Ridiane Denis, Anna C. Belkina, Rebecca M. Baron, Mayra Pinilla-Vera, Meike Mueller, W. Taylor Kimberly, Joshua N. Goldstein, Irina Lehmann, Angela R. Shih, Roland Eils, Bruce D. Levy, Nelson Ruiz-Opazo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-24 (2022)
Abstract Neutrophil-mediated secondary tissue injury underlies acute respiratory distress syndrome (ARDS) and progression to multi-organ-failure (MOF) and death, processes linked to COVID-19-ARDS. This secondary tissue injury arises from dysregulated
Externí odkaz:
https://doaj.org/article/e3433c566fb14028b1c283831cb361bc
Autor:
Joanne T. deKay, Ivette F. Emery, Jonathan Rud, Ashley Eldridge, Christine Lord, David J. Gagnon, Teresa L. May, Victoria L. M. Herrera, Nelson Ruiz-Opazo, Richard R. Riker, Douglas B. Sawyer, Sergey Ryzhov, David B. Seder
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract SARS-CoV-2 infection results in a spectrum of outcomes from no symptoms to widely varying degrees of illness to death. A better understanding of the immune response to SARS-CoV-2 infection and subsequent, often excessive, inflammation may in
Externí odkaz:
https://doaj.org/article/7f8cafdfa06e450c8c3f9913a5c5c788
Autor:
Saskia Carstensen, Meike Müller, Glaiza L. A. Tan, Khristine Amber Pasion, Jens M. Hohlfeld, Victoria L. M. Herrera, Nelson Ruiz-Opazo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background and objectiveThe correlation (Rs > 0.7) of neutrophils expressing the dual endothelin1/signal peptide receptor (DEspR+CD11b+/CD66b+) with severity of hypoxemia (SF-ratio) and multi-organ failure (SOFA-score) in patients with acute respirat
Externí odkaz:
https://doaj.org/article/a402768b25f34218b6105a4db2b4c356
Autor:
Victoria L. M. Herrera, Courtney E. Takahashi, Mai Q. Nguyen, Julie Z. Mosaddeghi, Ridiane Denis, David M. Greer, Nelson Ruiz-Opazo
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectiveCumulative clinical, cellular, and molecular evidence reinforces the role of neutrophils in secondary brain injury in spontaneous intracerebral hemorrhage (sICH). However, since generalized neutrophil inhibition is detrimental, identificatio
Externí odkaz:
https://doaj.org/article/47537858567741b68273da9d1eb5323e
Autor:
Christopher M. Gromisch, Glaiza L. A. Tan, Khristine Amber Pasion, Ann-Marie Moran, Matthew S. Gromisch, Mark W. Grinstaff, Francis J. Carr, Victoria L. M. Herrera, Nelson Ruiz-Opazo
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-21 (2021)
Abstract Background Pancreatic peritoneal carcinomatosis (PPC), with the worst median overall-survival (mOS), epitomizes the incurability of metastatic cancer. Cancer stem cells (CSCs) underpin this incurability. However, inhibitors of CSC-stemness f
Externí odkaz:
https://doaj.org/article/5ea42cacfaf84367ad190f7c6d297db5
Autor:
Victoria L Herrera, Khristine A Pasion, Ann Marie Moran, Roberta Zaninello, Maria Francesca Ortu, Giovanni Fresu, Daniela Antonella Piras, Giuseppe Argiolas, Chiara Troffa, Valeria Glorioso, Wanda Masala, Nicola Glorioso, Nelson Ruiz-Opazo
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116724 (2015)
Identification of susceptibility genes for essential hypertension in humans has been a challenge due to its multifactorial pathogenesis complicated by gene-gene and gene-environment interactions, developmental programing and sex specific differences.
Externí odkaz:
https://doaj.org/article/34adf1faa6984d42999b771880b37258
Autor:
Victoria L Herrera, Julius L Decano, Glaiza A Tan, Ann M Moran, Khristine A Pasion, Yuichi Matsubara, Nelson Ruiz-Opazo
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85821 (2014)
A priori, a common receptor induced in tumor microvessels, cancer cells and cancer stem-like cells (CSCs) that is involved in tumor angiogenesis, invasiveness, and CSC anoikis resistance and survival, could underlie contemporaneous coordination of th
Externí odkaz:
https://doaj.org/article/e62466500160493eb73ed05c0ed7c44e
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107888 (2014)
Multiple clinical studies show that arterial stiffness, measured as pulse wave velocity (PWV), precedes hypertension and is an independent predictor of hypertension end organ diseases including stroke, cardiovascular disease and chronic kidney diseas
Externí odkaz:
https://doaj.org/article/432f3453c4ff4e73b7422335435c1f56