Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Nelson O Gekara"'
Autor:
Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)
The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo
Externí odkaz:
https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87859 (2014)
Polymorphonuclear leukocytes (PMNs) are essential for the human innate immune defense, limiting expansion of invading microorganisms. PMN turnover is controlled by apoptosis, but the regulating signaling pathways remain elusive, largely due to inhere
Externí odkaz:
https://doaj.org/article/bf340c2d000e4e3b866a2f07c0738954
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10250 (2010)
BACKGROUND: Toll-like receptors (TLRs) are among the first-line sentinels for immune detection and responsiveness to pathogens. The TLR2 subfamily of TLRs (TLR1, TLR2, TLR6) form heterodimers with each other and are thus able to recognize a broad ran
Externí odkaz:
https://doaj.org/article/ff4af3766daa40ee80844fac7efeaf34
Autor:
Maria Lopez Chiloeches, Anna Bergonzini, Océane C. B. Martin, Nicole Bergstein, Saskia F. Erttmann, Kyaw Min Aung, Nelson O. Gekara, Javier F. Avila Cariño, Ioannis S. Pateras, Teresa Frisan
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionTyphoid toxin-expressing Salmonella enterica causes DNA damage in the intestinal mucosa in vivo, activating the DNA damage response (DDR) in the absence of inflammation. To understand whether the tissue microenvironment constrains the inf
Externí odkaz:
https://doaj.org/article/0545a211a7184a09a1424f21bc292d35
Autor:
Saskia F. Erttmann, Nelson O. Gekara
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102046- (2023)
Summary: Bacterial membrane vesicles have emerged as gadgets allowing remote communication between the microbiota and distal host organs. Here we describe a protocol for enriching vesicles from serum and colon that could widely be adapted for other t
Externí odkaz:
https://doaj.org/article/00b4bcbfa7df4accbf1ddb0290b6a4ac
Publikováno v:
Cell Research. 33:325-327
Autor:
Saskia F. Erttmann, Patrycja Swacha, Kyaw Min Aung, Björn Brindefalk, Hui Jiang, Anetta Härtlova, Bernt Eric Uhlin, Sun N. Wai, Nelson O. Gekara
The microbiota are vital for immune homeostasis and provide a competitive barrier to bacterial and fungal pathogens. Here, we investigated how gut commensals modulate systemic immunity and response to viral infection. Antibiotic suppression of the gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad90aaabdc5f38c94fdde351588e4a2
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194835
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194835
Publikováno v:
Methods in enzymology. 625
Detection of DNA damage in cells is fundamental for the study of DNA repair and genome-instability associated processes including carcinogenesis. Many studies often rely on cytotoxicity assays to estimate genotoxicity. However, measurements of cytoto
Publikováno v:
Methods in enzymology. 625
Inflammasomes are multiprotein signaling platforms responsible for the maturation of pro-IL-1β and pro-IL-18 as well as the induction of an inflammatory cell death termed pyroptosis. Most inflammasomes consist of an upstream sensor, in most cases an
Publikováno v:
Methods in enzymology. 625
Ubiquitination is a reversible posttranslational modification that regulates nearly all cellular processes. The ubiquitin polypeptide is conjugated via its C-terminus to amine groups of lysine residues on target protein. Additionally, ubiquitins moie