Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nelson Miguel Varela"'
Autor:
Juan Pablo Cayún, Leslie Carol Cerpa, Alicia Colombo, Dante Daniel Cáceres, José Luis Leal, Felipe Reyes, Carolina Gutiérrez-Cáceres, Susan Calfunao, Nelson Miguel Varela, Luis Abel Quiñones
Publikováno v:
Current Oncology, Vol 31, Iss 1, Pp 274-295 (2024)
Colorectal cancer is a common disease, both in Chile and worldwide. The most widely used chemotherapy schemes are based on 5-fluorouracil (5FU) as the foundational drug (FOLFOX, CapeOX). Genetic polymorphisms have emerged as potential predictive biom
Externí odkaz:
https://doaj.org/article/963d0bfa7f8141508105364e2a0002dd
Publikováno v:
Biomédica: revista del Instituto Nacional de Salud, Vol 41, Iss 3, Pp 403-408 (2021)
Se presenta el caso clínico de una paciente de 10 años diagnosticada con miocardiopatía dilatada, quien registró valores en el índice internacional normalizado (International Normalized Ratio, INR) superiores a 10 con la dosis estándar de aceno
Externí odkaz:
https://doaj.org/article/4cf44dd1e16a433a9b78a83e62d250c9
Autor:
Ángel Tito Alvarado, Ana María Muñoz, Berta Loja, Jessica Michiko Miyasato, Jorge Antonio García, Roberto Andrés Cerro, Luis Abel Quiñones, Nelson Miguel Varela
Publikováno v:
Biomédica: revista del Instituto Nacional de Salud, Vol 39, Iss 3, Pp 601-610 (2019)
Introducción. El citocromo CYP2C9 metaboliza, aproximadamente, el 15 % de los fármacos prescritos. Su gen presenta alelos cuyas frecuencias difieren entre grupos étnicos y poblaciones. Los alelos CYP2C9*2 y CYP2C9*3 dan cuenta de una enzima con ac
Externí odkaz:
https://doaj.org/article/d2728c109266448a8e5a8a41aa184753
Autor:
Mario Rojo MSc, Angela Margarita Roco PhD, Marcelo Suarez MSc, Maria Alejandra Lavanderos PhD, Gabriel Verón MSc, Maria Paz Bertoglia PhD, Annabella Arredondo MD, Elena Nieto MD, Juan Carlos Rubilar MSc, Francisca Tamayo PCh, Daniela Cruz MSc, Jessica Muñoz MSc, Gabriela Bravo MSc, Patricio Salas MD, Fanny Mejías MD, Paulo Véliz MSc, Gerald Godoy MSc, Nelson Miguel Varela PhD, G. Llull MSc, Luis Abel Quiñones PhD
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 26 (2020)
Despite the development of new oral agents over the last decade, vitamin K antagonists (VKAs) remain the most widely used anticoagulants for treating and preventing thromboembolism worldwide. In Chile, the Ministry of Health indicates that acenocouma
Externí odkaz:
https://doaj.org/article/b3dbe867447c497f89dcb22acc4925d3
Autor:
Angela Margarita Roco, Luis Abel Quiñones, José A G Agúndez, Elena eGarcía-Martín, Valentina eSquicciarini, Carla Estefania Miranda, Joselyn eGaray, Nancy eFarfán, Iván Nicolás Saavedra, Dante Daniel Caceres, Carol eIbarra, Nelson Miguel Varela
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile is 133.7/100,000 inhabitants and it is the second cause of death, after cardiovascular diseases. Most of the antineoplastic drugs are metabolized to be detoxified, and s
Externí odkaz:
https://doaj.org/article/b109014d66f44d5f8560f6dd3656da52
Publikováno v:
Biomédica
We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, forcing the discontinuati
Autor:
Ángel Tito, Alvarado, Ana María, Muñoz, Berta, Loja, Jessica Michiko, Miyasato, Jorge Antonio, García, Roberto Andrés, Cerro, Luis Abel, Quiñones, Nelson Miguel, Varela
Publikováno v:
Biomédica : Revista del Instituto Nacional de Salud
Introduction: CYP2C9 metabolizes approximately 15% of the prescribed drugs. Its gene has alleles whose frequencies differ between ethnic groups and populations. The alleles CYP2C9*2 and CYP2C9*3 account for an enzyme with decreased activity and their