Výsledky vyhledávání - "Nelson M. S. Wat"

Akademický článek

Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction.

Autor: Yu-Cho Woo, Annette W K Tso, Aimin Xu, Lawrence S C Law, Carol H Y Fong, Tai-Hing Lam, Su-Vui Lo, Nelson M S Wat, Bernard M Y Cheung, Karen S L Lam

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36868 (2012)

BACKGROUND: Adipose tissue inflammation and dysregulated adipokine secretion are implicated in obesity-related insulin resistance and type 2 diabetes. We evaluated the use of serum adiponectin, an anti-inflammatory adipokine, and several proinflammat

Externí odkaz: https://doaj.org/article/7f4b4cd66d8347059d431b5a97fa3311

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Akademický článek

The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study.

Autor: Chloe Y Y Cheung, Annette W K Tso, Bernard M Y Cheung, Aimin Xu, Carol H Y Fong, K L Ong, Lawrence S C Law, Nelson M S Wat, Edward D Janus, Pak C Sham, Karen S L Lam

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28598 (2011)

ContextThe KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies.ObjectiveThis study aimed to evaluate whether the E23K variant could pr

Externí odkaz: https://doaj.org/article/f861cd18556a428d8a5ddc33c012c322

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Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population

Autor: Karen S.L. Lam, Chloe Y Y Cheung, A. W. K. Tso, Kwok Leung Ong, Edward D. Janus, Nelson M. S. Wat, Pak C. Sham, Aimin Xu, Bernard M.Y. Cheung, Carol H. Y. Fong

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 95:1395-1403

Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants.This study aimed to examine 13 previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595f69899719b0a85e96c99f7d8ef158
https://doi.org/10.1210/jc.2009-1465

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Pro-inflammatory adipokines as predictors of incident cancers in a chinese cohort of low obesity prevalence in Hong Kong

Autor: Yu Cho Woo, Bernard M.Y. Cheung, Carol H. Y. Fong, A. W. K. Tso, Tai Hing Lam, Yu Wang, Jean Woo, Aimin Xu, Karen Siu-Ling Lam, CY Yeung, Su-Vui Lo, Nelson M. S. Wat

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78594 (2013)
PLoS ONE

Background Cytokines released from adipose tissues induce chronic low-grade inflammation, which may enhance cancer development. We investigated whether indices of obesity and circulating adipokine levels could predict incident cancer risk. Materials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be94a69235644177133b86a37e88e99f
http://hdl.handle.net/10722/193374

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Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study

Autor: Cheng, Chen, Annette W K, Tso, Bernard M Y, Cheung, Lawrence S C, Law, K L, Ong, Nelson M S, Wat, Edward D, Janus, Aimin, Xu, Karen S L, Lam

Publikováno v: Clinical endocrinology. 76(4)

Pigment epithelium-derived factor (PEDF) is secreted from the adipose tissue. It circulates at high concentrations, and was reported to play a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Previous cross-sectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab2145d7842d20c3647e4c4bd273609a
https://pubmed.ncbi.nlm.nih.gov/21777264

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High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects

Autor: Cheng, Chen, Bernard M Y, Cheung, Annette W K, Tso, Yudong, Wang, Lawrence S C, Law, Kwok Leung, Ong, Nelson M S, Wat, Aimin, Xu, Karen S L, Lam

Publikováno v: Diabetes Care

OBJECTIVE To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1c5ddbdbc0759398d93101765277f7e
https://pubmed.ncbi.nlm.nih.gov/21750278

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The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study

Autor: Lawrence S. C. Law, Edward D Janus, A. W. K. Tso, Aimin Xu, Karen S.L. Lam, Pak C. Sham, Nelson M. S. Wat, Bernard M.Y. Cheung, Kwok Leung Ong, Chloe Y Y Cheung, Carol H. Y. Fong

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28598 (2011)
PLoS ONE

Context: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. Objective: This study aimed to evaluate whether the E23K variant cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d30015cb67622f0f2a4f9a26731b1d
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22163043/pdf/?tool=EBI

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Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study

Autor: Kwok Leung Ong, Lawrence S. C. Law, Bernard M.Y. Cheung, Aimin Xu, A. W. K. Tso, Cheng Chen, Edward D Janus, Nelson M. S. Wat, Karen S.L. Lam

Publikováno v: The Journal of clinical endocrinology and metabolism. 95(11)

Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A recent study found that PEDF played a causal role in obesity-induced insulin resistance and metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5bfd82f8822be5b0b51e53c19bace9
https://pubmed.ncbi.nlm.nih.gov/20685859

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Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort

Autor: Annette W K, Tso, Aimin, Xu, Pak C, Sham, Nelson M S, Wat, Yu, Wang, Carol H Y, Fong, Bernard M Y, Cheung, Edward D, Janus, Karen S L, Lam

Publikováno v: Diabetes care. 30(10)

Adipocyte fatty acid-binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role in glucose homeostasis in experimental animals. We have previously shown that circulating A-FABP levels are associated with the metabolic syndrome, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b862d4a8ae03be35c1e804f8b7c486e
https://pubmed.ncbi.nlm.nih.gov/17620449

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Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis

Autor: M.T. Chau, Carol H.Y. Fong, M.H. Yau, Aimin Xu, Dennis C.Y. Yeung, C.W.S. Cheung, Karen S.L. Lam, Nelson M. S. Wat

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 27(8)

Objective— Adipocyte fatty acid–binding protein (A-FABP) has been shown to be an important player in atherosclerosis in animal models. However, the clinical relevance of these findings is still unknown. This study aims to examine the relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcdf2d508a1faeb52d2771a4200903b
https://pubmed.ncbi.nlm.nih.gov/17510463

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