Výsledky vyhledávání - "Nelson M. S. Wat"

Akademický článek

Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction.

Autor: Yu-Cho Woo, Annette W K Tso, Aimin Xu, Lawrence S C Law, Carol H Y Fong, Tai-Hing Lam, Su-Vui Lo, Nelson M S Wat, Bernard M Y Cheung, Karen S L Lam

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36868 (2012)

BACKGROUND: Adipose tissue inflammation and dysregulated adipokine secretion are implicated in obesity-related insulin resistance and type 2 diabetes. We evaluated the use of serum adiponectin, an anti-inflammatory adipokine, and several proinflammat

Externí odkaz: https://doaj.org/article/7f4b4cd66d8347059d431b5a97fa3311

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Akademický článek

The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study.

Autor: Chloe Y Y Cheung, Annette W K Tso, Bernard M Y Cheung, Aimin Xu, Carol H Y Fong, K L Ong, Lawrence S C Law, Nelson M S Wat, Edward D Janus, Pak C Sham, Karen S L Lam

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28598 (2011)

ContextThe KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies.ObjectiveThis study aimed to evaluate whether the E23K variant could pr

Externí odkaz: https://doaj.org/article/f861cd18556a428d8a5ddc33c012c322

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Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population

Autor: Karen S.L. Lam, Chloe Y Y Cheung, A. W. K. Tso, Kwok Leung Ong, Edward D. Janus, Nelson M. S. Wat, Pak C. Sham, Aimin Xu, Bernard M.Y. Cheung, Carol H. Y. Fong

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 95:1395-1403

Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants.This study aimed to examine 13 previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595f69899719b0a85e96c99f7d8ef158
https://doi.org/10.1210/jc.2009-1465

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Pro-inflammatory adipokines as predictors of incident cancers in a chinese cohort of low obesity prevalence in Hong Kong

Autor: Yu Cho Woo, Bernard M.Y. Cheung, Carol H. Y. Fong, A. W. K. Tso, Tai Hing Lam, Yu Wang, Jean Woo, Aimin Xu, Karen Siu-Ling Lam, CY Yeung, Su-Vui Lo, Nelson M. S. Wat

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78594 (2013)
PLoS ONE

Background Cytokines released from adipose tissues induce chronic low-grade inflammation, which may enhance cancer development. We investigated whether indices of obesity and circulating adipokine levels could predict incident cancer risk. Materials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be94a69235644177133b86a37e88e99f
http://hdl.handle.net/10722/193374

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Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study

Autor: Cheng, Chen, Annette W K, Tso, Bernard M Y, Cheung, Lawrence S C, Law, K L, Ong, Nelson M S, Wat, Edward D, Janus, Aimin, Xu, Karen S L, Lam

Publikováno v: Clinical endocrinology. 76(4)

Pigment epithelium-derived factor (PEDF) is secreted from the adipose tissue. It circulates at high concentrations, and was reported to play a causal role in obesity-induced insulin resistance and metabolic dysfunctions in mice. Previous cross-sectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab2145d7842d20c3647e4c4bd273609a
https://pubmed.ncbi.nlm.nih.gov/21777264

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High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects

Autor: Cheng, Chen, Bernard M Y, Cheung, Annette W K, Tso, Yudong, Wang, Lawrence S C, Law, Kwok Leung, Ong, Nelson M S, Wat, Aimin, Xu, Karen S L, Lam

Publikováno v: Diabetes Care

OBJECTIVE To investigate whether circulating levels of fibroblast growth factor 21 (FGF21), which previously has been shown to be elevated in obesity, could predict the development of type 2 diabetes in a 5.4-year, population-based, prospective study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1c5ddbdbc0759398d93101765277f7e
https://pubmed.ncbi.nlm.nih.gov/21750278

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The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study

Autor: Lawrence S. C. Law, Edward D Janus, A. W. K. Tso, Aimin Xu, Karen S.L. Lam, Pak C. Sham, Nelson M. S. Wat, Bernard M.Y. Cheung, Kwok Leung Ong, Chloe Y Y Cheung, Carol H. Y. Fong

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28598 (2011)
PLoS ONE

Context: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. Objective: This study aimed to evaluate whether the E23K variant cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d30015cb67622f0f2a4f9a26731b1d
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22163043/pdf/?tool=EBI

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Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study

Autor: Kwok Leung Ong, Lawrence S. C. Law, Bernard M.Y. Cheung, Aimin Xu, A. W. K. Tso, Cheng Chen, Edward D Janus, Nelson M. S. Wat, Karen S.L. Lam

Publikováno v: The Journal of clinical endocrinology and metabolism. 95(11)

Pigment epithelium-derived factor (PEDF), a serine protease inhibitor, is secreted from the adipose tissue and circulates at high concentrations. A recent study found that PEDF played a causal role in obesity-induced insulin resistance and metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5bfd82f8822be5b0b51e53c19bace9
https://pubmed.ncbi.nlm.nih.gov/20685859

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Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis

Autor: Nelson M. S. Wat, Daniel Y. T. Fong, Pak C. Sham, Aimin Xu, Karen S.L. Lam, Dennis C.Y. Yeung, Carol H. Y. Fong, MT Chau, Stephen C W Cheung, Yu Wang

Publikováno v: European heart journal. 29(17)

Aims Epidermal fatty-acid-binding protein (E-FABP) is highly homologous to adipocyte FABP (A-FABP), which mediates obesity-related metabolic syndrome (MetS), diabetes and atherosclerosis in animals. Combined deficiency of E-FABP and A-FABP protects a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d394d429b7b7cd8653bf734019f81ec4
https://pubmed.ncbi.nlm.nih.gov/18603624

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Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort

Autor: Annette W K, Tso, Aimin, Xu, Pak C, Sham, Nelson M S, Wat, Yu, Wang, Carol H Y, Fong, Bernard M Y, Cheung, Edward D, Janus, Karen S L, Lam

Publikováno v: Diabetes care. 30(10)

Adipocyte fatty acid-binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role in glucose homeostasis in experimental animals. We have previously shown that circulating A-FABP levels are associated with the metabolic syndrome, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b862d4a8ae03be35c1e804f8b7c486e
https://pubmed.ncbi.nlm.nih.gov/17620449

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