Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nelson Jeng Yeou, Chear"'
Autor:
Aiman Nadhirah Zul Aznal, Nurul Aqmar Mohamad Nor Hazalin, Zurina Hassan, Noorul Hamizah Mat, Nelson Jeng-Yeou Chear, Lay Kek Teh, Mohd Zaki Salleh, Farah Wahida Suhaimi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Adolescence is a critical developmental period during which exposure to psychoactive substances like kratom (Mitragyna speciosa) can cause long-lasting deleterious effects. Here, we evaluated the effects of mitragynine, the main alkaloid of kratom, a
Externí odkaz:
https://doaj.org/article/60ef325c8c884cd88968fe9e373ec44d
Autor:
Jia Lin Teh, Siti Fairus Abdul Rahman, Gregory Domnic, Lengishwarra Satiyasilan, Nelson Jeng Yeou Chear, Darshan Singh, Nethia Mohana-Kumaran
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Objective The spheroid model provides a physiological platform to study cancer cell biology and drug sensitivity. Usage of bovine collagen I for spheroid assays is costly especially when experiments are conducted in 24-well plates, as high v
Externí odkaz:
https://doaj.org/article/798d59ac402f42ef9d91b1247f172136
Autor:
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi-Yeong Khaw, Francisco León, Wen-Nee Tan, Siti R. Yusof, Christopher R. McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan
Publikováno v:
Metabolites, Vol 13, Iss 3, p 390 (2023)
The Uncaria genus is notable for its therapeutic potential in treating age-related dementia, such as Alzheimer’s disease. A phytochemical study of the leaves of Malaysian Uncaria attenuata Korth., afforded an undescribed natural corynanthe-type oxi
Externí odkaz:
https://doaj.org/article/59206ecad3da457e9c9c0a6ce70310fb
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Parallel to the growing use of kratom, there is a wealth of evidence from self-report, preclinical, and early clinical studies on therapeutic benefits of its alkaloids in particular for treating pain, managing substance use disorder, and coping with
Externí odkaz:
https://doaj.org/article/a1678a3899b74e15988f2d345e57a552
Autor:
Majed Ahmed Al-Mansoub, Muhammad Asif, Vageesh Revadigar, Mohamed A. Hammad, Nelson Jeng-Yeou Chear, Mohammad Razak Hamdan, Amin Malik Shah Abdul Majid, Mohd Zaini Asmawi, Vikneswaran Murugaiyah
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 57 (2021)
The ethanolic extract of resinous sediment (EERS) of Etlingera elatior young inflorescence was examined for its anticancer effect and potential antioxidant activity. The anticancer effect of the EERS was evaluated on four human cancer cell lines, HCT
Externí odkaz:
https://doaj.org/article/db979441b9b148e9bcef921b7bb990b7
Autor:
Thenmoly Damodaran, Nelson Jeng-Yeou Chear, Vikneswaran Murugaiyah, Mohd Nizam Mordi, Surash Ramanathan
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Kratom (Mitragyna speciosa Korth), a popular opioid-like plant holds its therapeutic potential in pain management and opioid dependence. However, there are growing concerns about the safety or potential toxicity risk of kratom after prolo
Externí odkaz:
https://doaj.org/article/6f6ef41238a94efe9c7685f91d9c49a4
Autor:
Wen-Nee Tan, Kashvintha Nagarajan, Vuanghao Lim, Juzaili Azizi, Kooi-Yeong Khaw, Woei-Yenn Tong, Chean-Ring Leong, Nelson Jeng-Yeou Chear
Publikováno v:
Journal of Fungi, Vol 8, Iss 5, p 519 (2022)
Endophytic fungi are a promising source of bioactive metabolites with a wide range of pharmacological activities. In the present study, MS-based metabolomics was conducted to study the metabolomes variations of endophytic Diaporthe fraxini ED2 grown
Externí odkaz:
https://doaj.org/article/3a62008998974e759a9a24ddfab9e28b
Autor:
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw
Publikováno v:
Biology, Vol 11, Iss 2, p 307 (2022)
Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections. There are research interests in recent years on terpene-derived metabolites (dite
Externí odkaz:
https://doaj.org/article/2cdb9f07bc25445b8d571810e16103b3
Autor:
Mohammad Farris Iman Leong Bin Abdullah, Kok Leng Tan, Salbiah Mohd Isa, Nur Sabrina Yusoff, Nelson Jeng Yeou Chear, Darshan Singh
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234639 (2020)
Background and aimKratom, or Mitragyna speciosa Korth., is a tropical plant that has been reported to exhibit opioid-like effects. Although opioids have been demonstrated to alter the lipid profile of regular users, data on the lipid-altering effects
Externí odkaz:
https://doaj.org/article/46d06e716d0944e1b51e218c261c157b
Publikováno v:
Molecules, Vol 26, Iss 5, p 1489 (2021)
The leaves of Carica papaya (CP) are rich in natural antioxidants. Carica papaya has traditionally been used to treat various ailments, including skin diseases. This study aims to decipher the antioxidant effects and phytochemical content of differen
Externí odkaz:
https://doaj.org/article/a9f56593fdfb47f992e5872bf829e2af