Type II innate lymphoid cell plasticity contributes to impaired reconstitution after allogeneic hematopoietic stem cell transplantation

Autor: Sonia J. Laurie, Joseph P. Foster, Danny W. Bruce, Hemamalini Bommiasamy, Oleg V. Kolupaev, Mostafa Yazdimamaghani, Samantha G. Pattenden, Nelson J. Chao, Stefanie Sarantopoulos, Joel S. Parker, Ian J. Davis, Jonathan S. Serody

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Type II innate lymphoid cells (ILC2s) maintain homeostasis and barrier integrity in mucosal tissues. In both mice and humans, ILC2s poorly reconstitute after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Determining the mec

Externí odkaz: https://doaj.org/article/deafa590173041a485a51c32ab3e3f46

The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children

Autor: Sarah M. Heston, Rebecca R. Young, Kirsten Jenkins, Paul L. Martin, Andre Stokhuyzen, Doyle V. Ward, Shakti K. Bhattarai, Vanni Bucci, Mehreen Arshad, Nelson J. Chao, Patrick C. Seed, Matthew S. Kelly

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk of colonization by antibiotic-resistant bacteria. We performe

Externí odkaz: https://doaj.org/article/d2335a9a9731460b886256ce7c724bc0

Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Autor: Huisheng Ai, Nelson J. Chao, David A. Rizzieri, Xiaojun Huang, Thomas R. Spitzer, Jianxiang Wang, Mei Guo, Armand Keating, Elizabeth F. Krakow, Didier Blaise, Jun Ma, Depei Wu, John Reagan, Usama Gergis, Rafael F. Duarte, Preet M. Chaudhary, Kaixun Hu, Changlin Yu, Qiyun Sun, Ephraim Fuchs, Bo Cai, Yajing Huang, Jianhui Qiao, David Gottlieb, Kirk R. Schultz, Mingyao Liu, Xiequn Chen, Wenming Chen, Jianmin Wang, Xiaohui Zhang, Jianyong Li, He Huang, Zimin Sun, Fei Li, Linhua Yang, Liansheng Zhang, Lijuan Li, Kaiyan Liu, Jie Jin, Qifa Liu, Daihong Liu, Chunji Gao, Chuanbo Fan, Li Wei, Xi Zhang, Liangding Hu, Weijing Zhang, Yuyang Tian, Weidong Han, Jun Zhu, Zhijian Xiao, Daobin Zhou, Bolong Zhang, Yongqian Jia, Yongqing Zhang, Xiaoxiong Wu, Xuliang Shen, Xuzhang Lu, Xinrong Zhan, Xiuli Sun, Yi Xiao, Jingbo Wang, Xiaodong Shi, Bo Zheng, Jieping Chen, Banghe Ding, Zhao Wang, Fan Zhou, Mei Zhang, Yizhuo Zhang, Jie Sun, Bing Xia, Baoan Chen, Liangming Ma

Publikováno v: Heliyon, Vol 9, Iss 4, Pp e14924- (2023)

Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MS

Externí odkaz: https://doaj.org/article/856fec91f1344a8b9074383ae4ab2604

Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia

Autor: Sharareh Siamakpour-Reihani, Felicia Cao, Jing Lyu, Yi Ren, Andrew B. Nixon, Jichun Xie, Amy T. Bush, Mark D. Starr, James R. Bain, Michael J. Muehlbauer, Olga Ilkayeva, Virginia Byers Kraus, Janet L. Huebner, Nelson J. Chao, Anthony D. Sung

Publikováno v: PLoS ONE, Vol 17, Iss 6 (2022)

Although hematopoietic stem cell transplantation (HCT) is the only curative treatment for acute myeloid leukemia (AML), it is associated with significant treatment related morbidity and mortality. There is great need for predictive biomarkers associa

Externí odkaz: https://doaj.org/article/b4b09d353c214ef2b6362d7af17d6400

Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality

Autor: Ko Maung, Sendhilnathan Ramalingam, Mohammad Chaudhry, Yi Ren, Sin-Ho Jung, Kristi Romero, Kelly Corbet, Nelson J. Chao, Taewoong Choi, Anna Mae Diehl, Louis Diehl, Cristina Gasparetto, Mitchell Horwitz, Gwynn Douglas Long, Richard D. Lopez, David A. Rizzieri, Stefanie Sarantopoulos, Keith M. Sullivan, Mustafa R. Bashir, Anthony D. Sung, Gianfranco D. Alpini

Publikováno v: PLoS ONE, Vol 15, Iss 9 (2020)

Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic ste

Externí odkaz: https://doaj.org/article/c1d9528417af4ac88e3b02f0974c2a02