Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nelson Humala"'
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
Externí odkaz:
https://doaj.org/article/d887ba793f1142b985b1d97d66d45514
Autor:
Lisa Sprinzen, Franklin Garcia, Angeliki Mela, Liang Lei, Pavan Upadhyayula, Aayushi Mahajan, Nelson Humala, Lisa Manier, Richard Caprioli, Alfredo Quiñones-Hinojosa, Patrizia Casaccia, Peter Canoll
Publikováno v:
Cells, Vol 13, Iss 3, p 219 (2024)
Isocitrate Dehydrogenase-1 (IDH1) is commonly mutated in lower-grade diffuse gliomas. The IDH1R132H mutation is an important diagnostic tool for tumor diagnosis and prognosis; however, its role in glioma development, and its impact on response to the
Externí odkaz:
https://doaj.org/article/29984ddfb1b640858558c0a9d472a605
Autor:
Trang T. T. Nguyen, Enyuan Shang, Chang Shu, Sungsoo Kim, Angeliki Mela, Nelson Humala, Aayushi Mahajan, Hee Won Yang, Hasan Orhan Akman, Catarina M. Quinzii, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Glioblastoma patients are treated with Aurora kinase A (AURKA) inhibitors but resistance can occur. Here, the authors show that AURKA inhibition induces metabolic reprogramming, which leads to increased mitochondrial activity and inhibition of oxidat
Externí odkaz:
https://doaj.org/article/f4ce109d7c6840f1a279ca28a9499ce7
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
Figure S1. Crizotinib resistant cells reveal a reprogrammed tumor metabolism. Figure S2. Crizotinib modulates fatty acid metabolism and mitochondrial parameters. Figure S3. Tracing analysis reveals distinct modulation of metabolism by MET inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3ca270b2531ae2a9908279f0411cd4
https://doi.org/10.1158/0008-5472.22423917.v1
https://doi.org/10.1158/0008-5472.22423917.v1
Autor:
Markus D. Siegelin, Peter Canoll, Jeffrey N. Bruce, Georg Karpel-Massler, Catarina M. Quinzii, Mike-Andrew Westhoff, Elena Bianchetti, Giulio Kleiner, Maria J. Sanchez-Quintero, Consuelo Torrini, Chang Shu, Junfei Zhao, Aayushi Mahajan, Nelson Humala, Angeliki Mela, Enyuan Shang, Trang T.T. Nguyen, Yiru Zhang
The receptor kinase c-MET has emerged as a target for glioblastoma therapy. However, treatment resistance emerges inevitably. Here, we performed global metabolite screening with metabolite set enrichment coupled with transcriptome and gene set enrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6927c0d5296b85502a38feeb20f8211
https://doi.org/10.1158/0008-5472.c.6511608.v1
https://doi.org/10.1158/0008-5472.c.6511608.v1
Autor:
Matei A. Banu, Athanassios Dovas, Michael G. Argenziano, Wenting Zhao, Henar Cuervo Grajal, Dominique M.O. Higgins, Colin P. Sperring, Brianna Pereira, Ling F. Ye, Aayushi Mahajan, Nelson Humala, Julia L. Furnari, Pavan S. Upadhyayula, Fereshteh Zandkarimi, Trang T. T. Nguyen, Peter B. Wu, Li Hai, Charles Karan, Aida Razavilar, Markus D. Siegelin, Jan Kitajewski, Jeffrey N. Bruce, Brent R. Stockwell, Peter A. Sims, Peter D. Canoll
Publikováno v:
bioRxiv
SUMMARYGlioma cells hijack developmental transcriptional programs to control cell state. During neural development, lineage trajectories rely on specialized metabolic pathways. However, the link between tumor cell state and metabolic programs is poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d307a66d6e7e7bb3360567afe6f972d
https://doi.org/10.1101/2023.02.22.529581
https://doi.org/10.1101/2023.02.22.529581
Autor:
Zhouzerui Liu, Angeliki Mela, Julia Furnari, Michael G. Argenziano, Corina Kotidis, Colin P. Sperring, Nelson Humala, Jeffrey N. Bruce, Peter Canoll, Peter A. Sims
Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor, and surgical resection is a key part of the standard-of-care. In fluorescence-guided surgery (FGS), fluorophores are used to differentiate tumor tissue from surroundi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f92139f490e1e9786f0b83b81faf6b
https://doi.org/10.1101/2022.12.17.520870
https://doi.org/10.1101/2022.12.17.520870
Autor:
Eleonora F Spinazzi, Michael G Argenziano, Pavan S Upadhyayula, Matei A Banu, Justin A Neira, Dominique M O Higgins, Peter B Wu, Brianna Pereira, Aayushi Mahajan, Nelson Humala, Osama Al-Dalahmah, Wenting Zhao, Akshay V Save, Brian J A Gill, Deborah M Boyett, Tamara Marie, Julia L Furnari, Tejaswi D Sudhakar, Sylwia A Stopka, Michael S Regan, Vanessa Catania, Laura Good, Stergios Zacharoulis, Meenu Behl, Petros Petridis, Sachin Jambawalikar, Akiva Mintz, Angela Lignelli, Nathalie Y R Agar, Peter A Sims, Mary R Welch, Andrew B Lassman, Fabio M Iwamoto, Randy S D’Amico, Jack Grinband, Peter Canoll, Jeffrey N Bruce
Publikováno v:
Lancet Oncol
Topotecan is cytotoxic to glioma cells but is clinically ineffective because of drug delivery limitations. Systemic delivery is limited by toxicity and insufficient brain penetrance, and, to date, convection-enhanced delivery (CED) has been restricte
Autor:
Eleonora F. Spinazzi, Michael G. Argenziano, Pavan S. Upadhyayula, Matei A. Banu, Justin A. Neira, Dominique M.O. Higgins, Peter B. Wu, Brianna Pereira, Aayushi Mahajan, Nelson Humala, Osama Al-Dalahmah, Wenting Zhao, Akshay V. Save, Deborah M. Boyett, Tamara Marie, Julia L Furnari, Tejaswi D. Sudhakar, Sylwia A. Stopka, Michael S. Regan, Vanessa Catania, Laura Good, Meenu Behl, Sachin Jambawalikar, Akiva Mintz, Angela Lignelli, Nathalie Y.R. Agar, Peter A. Sims, Mary Welch, Andrew Lassman, Fabio Iwamoto, Randy S. D’Amico, Jack Grinband, Peter Canoll, Jeffrey N. Bruce
Glioblastoma, the most common primary brain malignancy, is invariably fatal. Systemic chemotherapy is ineffective mostly because of drug delivery limitations. To overcome this, we devised an internalized pump-catheter system for direct chronic convec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e662be7b4518bea92e47e3dde561c23f
https://doi.org/10.1101/2021.12.04.21266935
https://doi.org/10.1101/2021.12.04.21266935