Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Nelson, Lissa"'
Autor:
Nelson Lissa T, Tatyana Dekhtyar, DeAnne Stolarik, Thomas Reisch, Warren M. Kati, Donner Pamela L, Tami Pilot-Matias, Sachin V. Patel, Rolf Wagner, Preethi Krishnan, Douglas K. Hutchinson, Todd W. Rockway, Neeta Mistry, David W A Beno, Rubina Mondal, Clarence J. Maring, John T. Randolph, Charles A. Flentge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5462-5467
Research toward a next-generation HCV NS5A inhibitor has identified fluorobenzimidazole analogs that demonstrate potent, broad-genotype in vitro activity against HCV genotypes 1-6 replicons as well as HCV NS5A variants that are orders of magnitude le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2463cd55a42d5272f0d4aea2f05fd715
https://doi.org/10.1016/j.bmcl.2016.10.030
https://doi.org/10.1016/j.bmcl.2016.10.030
Autor:
Ryan G. Keddy, Warren M. Kati, Tami Pilot-Matias, Nelson Lissa T, DeAnne Stolarik, Tatyana Dekhtyar, Rubina Mondal, Thomas Reisch, A. Chris Krueger, Hutchinson Douglas K, Donner Pamela L, John T. Randolph, Wenqing Gao, David A. Betebenner, Clarence J. Maring, Preethi Krishnan, Neeta S. Panchal, Christine A. Collins, Todd W. Rockway, Yi Gao, Teresa I. Ng, David W A Beno, John K. Pratt, Dachun Liu, Sachin V. Patel, Charles A. Flentge, Mark A. Matulenko, Rolf Wagner
Publikováno v:
Journal of medicinal chemistry. 61(9)
Curative interferon and ribavirin sparing treatments for hepatitis C virus (HCV)-infected patients require a combination of mechanistically orthogonal direct acting antivirals. A shared component of these treatments is usually an HCV NS5A inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0ea7f78cae0082405f10eb7a8974af
https://pubmed.ncbi.nlm.nih.gov/29653491
https://pubmed.ncbi.nlm.nih.gov/29653491
Autor:
Randolph, John T., Flentge, Charles A., Donner, Pamela, Rockway, Todd W., Patel, Sachin V., Nelson, Lissa, Hutchinson, Douglas K., Mondal, Rubina, Mistry, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Krishnan, Preethi, Pilot-Matias, Tami, Stolarik, Deanne F., Beno, David W.A., Wagner, Rolf, Maring, Clarence, Kati, Warren M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 November 2016 26(22):5462-5467
Akademický článek
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Autor:
Christine A. Collins, Mei Liu, Hongyu Zhao, Rich S. Janis, Heidi S. Camp, Teresa K. Surowy, Gang Liu, Bo Liu, Nelson Lissa T, Harriet T. Smith, Ning Cao, Tom S. Suhar, Michael D. Serby, Zhili Xin, Hing L. Sham, Bruce G. Szczepankiewicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4298-4302
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055af8cecf34aa640b107ce18838c33e
https://doi.org/10.1016/j.bmcl.2008.06.088
https://doi.org/10.1016/j.bmcl.2008.06.088
Autor:
Christopher Moore Killian, Elizabeth Forrester Mccord, Maurice Brookhart, Nelson Lissa Taka Jennings, Steven Dale Ittel, Daniel Joseph Tempel, Stephan James Mclain, Lynda Kaye Johnson
Publikováno v:
Macromolecules. 40:410-420
α-Diimine complexes of palladium and nickel catalyze the polymerization of α-olefins to give new materials that range from low-Tg elastomers to low-melting, partially crystalline polymers. The 1H a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cadd32f09d4711a799d97d7fe640ca55
https://doi.org/10.1021/ma061547m
https://doi.org/10.1021/ma061547m
Autor:
Hing L. Sham, Zhili Xin, Christi Kosogof, Terry Pederson, Hongyu Zhao, Cele Abad-Zapatero, Bo Liu, Michael D. Serby, Bruce G. Szczepankiewicz, Gang Liu, Cristina M. Rondinone, Nelson Lissa T, Deanna L. Haasch, Jill E. Clampit, Sanyi Wang, Rebecca J. Gum, James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Mei Liu
Publikováno v:
Journal of Medicinal Chemistry. 49:4455-4458
C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc463ce3c72249463613b7043f83c6a3
https://doi.org/10.1021/jm060465l
https://doi.org/10.1021/jm060465l
Autor:
James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Chaohong Sun, Hing L. Sham, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, Edward T. Olejniczak, Michael A. Stashko, Cele Abad-Zapatero, Michael D. Serby, Rebecca J. Gum, Hongyu Zhao, Kristi Haskins, Zhili Xin, Bo Liu, Sarah A Dorwin, Jill E. Clampit, Nelson Lissa T, Gang Liu, Mei Liu, Christi Kosogof, Cristina M. Rondinone, Sanyi Wang, Deanna L. Haasch
Publikováno v:
Journal of Medicinal Chemistry. 49:3563-3580
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5bb3bc96de29a87b4ec28bbfc5f96f
https://doi.org/10.1021/jm060199b
https://doi.org/10.1021/jm060199b
Autor:
Verlyn G. Schaefer, Michael D. Serby, Bo Liu, Christine A. Collins, H. Douglas Falls, Hongyu Zhao, Eugene N. Bush, Victoria Knourek-Segel, Theresa M Turner, Michael E. Brune, Gang Liu, Thomas A. Fey, Wiweka Kaszubska, Brian A. Droz, Christi Kosogof, Zhili Xin, David W A Beno, Robin Shapiro, Peer B. Jacobson, Bruce G. Szczepankiewicz, Mei Liu, Nelson Lissa T, Hing L. Sham
Publikováno v:
Journal of Medicinal Chemistry. 49:2568-2578
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d352477e306be3be634175471489d0
https://doi.org/10.1021/jm0510934
https://doi.org/10.1021/jm0510934
Autor:
Shi-Chung Ng, Gerard M. Sullivan, Weibo Wang, Hovis M. Imade, Stephen J. O'connor, Haiying Zhang, Hing L. Sham, Stephen L. Gwaltney, Saul H. Rosenberg, Lisa A. Hasvold, Jerome Cohen, Wen-Zhen Gu, Joy Bauch, Qun Li, Stephen K. Tahir, Steve Muchmore, Charles W. Hutchins, Kennan C. Marsh, Nelson Lissa T, Clarissa G. Jakob, Vincent S. Stoll, David Frost
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1359-1362
Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace2fe027ea17136753c78626be974f
https://doi.org/10.1016/s0960-894x(03)00095-7
https://doi.org/10.1016/s0960-894x(03)00095-7