Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nels B. Hamacher"'
Publikováno v:
Proceedings of the National Academy of Sciences. 112:833-838
Fc gamma receptor I (FcγRI) contributes to protective immunity against bacterial infections, but exacerbates certain autoimmune diseases. The sole high-affinity IgG receptor, FcγRI plays a significant role in immunotherapy. To elucidate the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778cd11f6c312a0f41a89373bd17603f
https://doi.org/10.1073/pnas.1418812112
https://doi.org/10.1073/pnas.1418812112
Autor:
Nels B. Hamacher, Megan M. Lantry, Pallavur V. Sivakumar, Robert Rosler, Brenda L. Stevens, Secil Franke, Craig D. Ostrander, Debra G. Gilbertson, Penny Thompson, Mark Snavely, Cindy Yen, Tom Bukowski, Anitra Wolf, Hank Franklin, Robert Mabry, Dan Ardourel, Kenneth Brasel, Scott R. Presnell, Qi Pan, Julien Susan H, Michael G. Dodds, Amanda Frank, Scott Peterson, Tuyen Vu, Monica Anderson-Haley, Brent Meengs, Sara Underwood, Jennifer A. Brody
Publikováno v:
mAbs. 2:20-34
Targeting angiogenesis is a promising approach to the treatment of solid tumors and age-related macular degeneration (AMD). Inhibition of vascularization has been validated by the successful marketing of monoclonal antibodies (mAbs) that target speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5661385a95b8994d0b6f369e357c8c
https://doi.org/10.4161/mabs.2.1.10498
https://doi.org/10.4161/mabs.2.1.10498
Publikováno v:
BioTechniques. 28:934-937
A dot immunoblotting technique has been developed to estimate the relative expression levels of tagged recombinant human proteins in mammalian cell culture media. Variations in sample denaturation, blocking agents and membrane composition and treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c675500011dbe3e91a93b766a32f5a8a
https://doi.org/10.2144/00285st07
https://doi.org/10.2144/00285st07
Autor:
Carl W. Birks, Megan M. Lantry, Nels B. Hamacher, Ken Lewis, Mark W. Rixon, Thomas R. Bukowski, Mark F. Maurer, Claire Noriega, Brandon Harder, Brent Meengs, Emily Rollins, Brian A. Fox, Karlien Greeff, Jeffrey D Meyer, Jeff L. Ellsworth
Publikováno v:
Protein engineering, designselection : PEDS. 23(4)
A recombinant soluble version of the human high-affinity receptor for IgG, rh-FcgammaRIA or CD64A, was expressed in mammalian cells and purified from their conditioned media. As assessed by circular dichroism, size exclusion chromatography and dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac07edf795df11c8005bd5735adb836
https://pubmed.ncbi.nlm.nih.gov/20150179
https://pubmed.ncbi.nlm.nih.gov/20150179
Autor:
Amanda Frank, Jennifer A. Brody, Ty Brender, Mark W. Appleby, Thomas R. Bukowski, Tuyen Vu, Kristen Bontadelli, Brian Reardon, Dan Ardourel, Luann Lockwood, Robert Mabry, Margaret D. Moore, Karen Lum, Brent Meengs, Patsy Lewis, Craig D. Ostrander, Nels B. Hamacher, Megan M. Lantry, Mark Snavely, Joseph L. Kuijper, Julien Susan H, James W. West, Brenda L. Stevens, Kenneth B. Lewis, Steven D. Levin, Kelly Byrnes-Blake, Chung Chan, Scott R. Presnell, Anitra Wolf, Okada Shannon L, Secil Franke, Debra G. Gilbertson, Katherine E. Lewis, Patricia A. Mckernan
Publikováno v:
Protein engineering, designselection : PEDS. 23(3)
Bispecific antibodies (bsAbs) present an attractive opportunity to combine the additive and potentially synergistic effects exhibited by combinations of monoclonal antibodies (mAbs). Current challenges for engineering bsAbs include retention of the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05481693612d2d61e29505fd2e53305d
https://pubmed.ncbi.nlm.nih.gov/20022918
https://pubmed.ncbi.nlm.nih.gov/20022918
Autor:
Kelly Byrnes-Blake, Colleen Oliver, Nels B. Hamacher, Katherine E. Lewis, Sara Underwood, Claire Noriega, Jeff L. Ellsworth, Brandon Harder, LuAnne Hebb, Kimberly S. Waggie, Ken Bannink, Mark W. Rixon, Thomas R. Bukowski
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 182(11)
Binding of immune complexes to cellular FcγRs can promote cell activation and inflammation. In previous studies, a recombinant human (rh) soluble FcγR, rh-FcγRIA (CD64A), was shown to block inflammation in passive transfer models of immune complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fe08f5893ad9ea32fa8dffb0896615
https://pubmed.ncbi.nlm.nih.gov/19454724
https://pubmed.ncbi.nlm.nih.gov/19454724
Autor:
Hong Liu, Jeff L. Ellsworth, Keith B. Elkon, Mark F. Maurer, Mark H. Wener, Cecile M. Krejsa, Susan Pederson, Maria Dall'Era, Margaret D. Moore, Brandon Harder, Thomas R. Bukowski, Jane A. Gross, Kenneth B. Lewis, Stacey R. Dillon, Nels B Hamacher, Megan M. Lantry
Publikováno v:
Arthritis Research & Therapy
Dillon, Stacey R; Harder, Brandon; Lewis, Kenneth B; Moore, Margaret D; Liu, Hong; Bukowski, Thomas R; et al.(2010). B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin. Arthritis Research & Therapy, 12(2), R48. doi: http://dx.doi.org/10.1186/ar2959. Retrieved from: http://www.escholarship.org/uc/item/79j6t5tr
Dillon, Stacey R; Harder, Brandon; Lewis, Kenneth B; Moore, Margaret D; Liu, Hong; Bukowski, Thomas R; et al.(2010). B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin. Arthritis Research & Therapy, 12(2), R48. doi: http://dx.doi.org/10.1186/ar2959. Retrieved from: http://www.escholarship.org/uc/item/79j6t5tr
Introduction B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed in a variety of autoimmune d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455dd6263927633f6e482286a2e41b88
http://europepmc.org/articles/PMC2888197
http://europepmc.org/articles/PMC2888197