Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Nelofer Syed"'
Publikováno v:
Cancers, Vol 16, Iss 11, p 2054 (2024)
Glioblastoma (GBM) cells require high levels of nicotinamide adenine dinucleotide (NAD) to fuel metabolic reactions, regulate their cell cycle and support DNA repair in response to chemotherapy and radiation. Inhibition of a key enzyme in NAD biosynt
Externí odkaz:
https://doaj.org/article/184eb29b576045d9aff130f03f5ac264
Autor:
Judith Schaf, Sonia Shinhmar, Qingyu Zeng, Olivier E. Pardo, Philip Beesley, Nelofer Syed, Robin S. B. Williams
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be investigated. One such approach involves the use of the bioactive natural product Tansh
Externí odkaz:
https://doaj.org/article/eb1ae5def32c41aba2ef94e86feb2080
Autor:
Sewanti Limaye, Simon Chowdhury, Nitesh Rohatgi, Anantbhushan Ranade, Nelofer Syed, Johann Riedemann, Darshana Patil, Dadasaheb Akolkar, Vineet Datta, Shoeb Patel, Rohit Chougule, Pradyumna Shejwalkar, Kiran Bendale, Sachin Apurwa, Stefan Schuster, Jinumary John, Ajay Srinivasan, Rajan Datar
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9116-9127 (2023)
Abstract Background The low specificity of serum PSA resulting in the inability to effectively differentiate prostate cancer from benign prostate conditions is a persistent clinical challenge. The low sensitivity of serum PSA results in false negativ
Externí odkaz:
https://doaj.org/article/9df8191d60ad4d7aa84a5cf4660a8892
Autor:
Nabil Hajji, Juan Garcia-Revilla, Manuel Sarmiento Soto, Richard Perryman, Jake Symington, Chad C. Quarles, Deborah R. Healey, Yijie Guo, Manuel Luis Orta-Vázquez, Santiago Mateos-Cordero, Khalid Shah, John Bomalaski, Giulio Anichini, Andreas G. Tzakos, Timothy Crook, Kevin O’Neill, Adrienne C. Scheck, Jose Luis Venero, Nelofer Syed
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20
Externí odkaz:
https://doaj.org/article/7a43ba7a6e2c46269a07eda280cc60bf
Autor:
Liisi Laaniste, Prashant K. Srivastava, Julianna Stylianou, Nelofer Syed, Silvia Cases‐Cunillera, Kirill Shkura, Qingyu Zeng, Owen J. L. Rackham, Sarah R. Langley, Andree Delahaye-Duriez, Kevin O'Neill, Matthew Williams, Albert Becker, Federico Roncaroli, Enrico Petretto, Michael R. Johnson
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)
Abstract Objective To identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy discovery. Methods Using an integrated functional genomics approach, we prioritized networks assoc
Externí odkaz:
https://doaj.org/article/5ca9a4cac564403083ba4ad6d5267303
Autor:
Shahmir Naseer, Laura Abelleira-Hervas, Dhwani Savani, Ross de Burgh, Robertas Aleksynas, Cornelius K. Donat, Nelofer Syed, Magdalena Sastre
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1457 (2022)
There is compelling evidence that head injury is a significant environmental risk factor for Alzheimer’s disease (AD) and that a history of traumatic brain injury (TBI) accelerates the onset of AD. Amyloid-β plaques and tau aggregates have been ob
Externí odkaz:
https://doaj.org/article/d9bb739aeae34cddb8183f5d92e8afe6
Publikováno v:
Journal of Neurological Surgery Reports, Vol 82, Iss 02, Pp e11-e16 (2021)
We present a case report of a 51-year-old left-handed male with a background of human papillomovairus 16-positive tonsil squamous cell carcinoma presenting with tonic-clonic seizure and a radiological diagnosis of secondary metastatic deposits. These
Externí odkaz:
https://doaj.org/article/279ad831fb314504a9eceebeecd619ba
Autor:
Stavroula G. Kyrkou, Eirinaios I. Vrettos, Dimitris Gorpas, Timothy Crook, Nelofer Syed, Andreas G. Tzakos
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 362 (2022)
The unmet need to develop novel approaches for cancer diagnosis and treatment has led to the evolution of theranostic agents, which usually include, in addition to the anticancer drug, an imaging agent based mostly on fluorescent agents. Over the pas
Externí odkaz:
https://doaj.org/article/ac67222595f748ba99ec0d5e7976768d
Autor:
Shuvolina Mukherjee, Deeptarup Biswas, Rucha Gadre, Pooja Jain, Nelofer Syed, Julianna Stylianou, Qingyu Zeng, Anita Mahadevan, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball, Sanjeeva Srivastava
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Meningiomas are one of the most prevalent primary brain tumors. Our study aims to obtain mechanistic insights of meningioma pathobiology using mass spectrometry-based label-free quantitative proteome analysis to identifying druggable targets and pert
Externí odkaz:
https://doaj.org/article/ac4e826e42c946429b9cd832cf2889a0
Autor:
Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1). These
Externí odkaz:
https://doaj.org/article/284c84f10abc44169584836fd2f255df