Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain

Autor: Cédric Mongellaz, Rita Vicente, Lenora M. Noroski, Nelly Noraz, Valérie Courgnaud, Javier Chinen, Emilia Faria, Valérie S. Zimmermann, Naomi Taylor

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the ZAP70 gene cause a combined immunodeficiency characterized by low or absent CD8+ T cell

Externí odkaz: https://doaj.org/article/9b8b9c74f3a9402ea679547b0d87cb55

Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition

Autor: Jianmei Liu, Junying Zhang, Nelly Noraz, Margaux Saint-Martin, Liang Wenjun, Fei Xu, Jérôme Honnorat, Heli Liu

Publikováno v: Journal of Autoimmunity. 96:168-177

Accumulating evidence has showed that anti-CASPR2 autoantibodies occur in a long list of neurological immune disorders including limbic encephalitis (LE). Belonging to the well-known neurexin superfamily, CASPR2 has been suggested to be a central nod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45bd8f064f8b9bb873d6ca0028b4f99
https://doi.org/10.1016/j.jaut.2018.09.012

The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons

Autor: Nelly Noraz, Maria Savvaki, Margaux Saint-Martin, Catherine Faivre-Sarrailh, Bruno Hivert, Delphine Pinatel, Domna Karagogeos

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2017, 130 (13), pp.2209-2220. ⟨10.1242/jcs.202267⟩
Journal of Cell Science, 2017, 130 (13), pp.2209-2220. ⟨10.1242/jcs.202267⟩

International audience; Caspr2 and TAG-1 (also known as CNTNAP2 and CNTN2, respectively) are cell adhesion molecules (CAMs) associated with the voltage-gated potassium channels Kv1.1 and Kv1.2 (also known as KCNA1 and KCNA2, respectively) at regions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476c448d8743ae2886c9b64d555c36c8
https://hal.archives-ouvertes.fr/hal-02322304

Syk kinases are required for spinal commissural axon repulsion at the midline via ephrin/Eph pathway

Autor: Camille Charoy, Nelly Noraz, Chantal Watrin, Céline Malleval, Naura Chounlamountri, Hélène Boudin, Valérie Castellani, Véronique Pellier-Monnin, Aurélien Benon, Jérôme Honnorat, Iness Jaaoini

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2016, 143 (12), pp.2183-2193. ⟨10.1242/dev.128629⟩
Development (Cambridge, England), Company of Biologists, 2016, 143 (12), pp.2183-2193. ⟨10.1242/dev.128629⟩

In the hematopoietic system, tyrosine kinases of Syk family are essential components of immunoreceptor ITAM-based signaling. While an increasing number of data involved immunoreceptors in neural functions, the contribution of Syk kinases remains obsc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbb04054bb390e5bee11e25caca24f6
https://doi.org/10.1242/dev.128629

Ectopic Expression of the Immune Adaptor Protein CD3zeta in Neural Stem/Progenitor Cells Disrupts Cell-Fate Specification

Autor: Zsolt Csaba, Virginie Bonnamain, Pascal Dournaud, Antoine Louveau, Hélène Boudin, Véronique Nerrière-Daguin, Nelly Noraz, Philippe Naveilhan, Julie Angibaud, Véronique Pellier-Monnin, Stéphane J. Baudouin

Publikováno v: Journal of Molecular Neuroscience. 46:431-441

Immune signaling and neuroinflammatory mediators have recently emerged as influential variables that regulate neural precursor/stem cell (NPC) behavior and function. In this study, we investigated whether the signaling adaptor protein CD3ζ, a transm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b9686f079df329e960aecabc911a13
https://doi.org/10.1007/s12031-011-9607-2