Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of

Autor: Marie Claire, Tchamadeu, Paul Désiré Djomeni, Dzeufiet, Nelly, Blaes, Jean-Pierre, Girolami, Pierre, Kamtchouing, Théophile, Dimo

Publikováno v: Pharmacognosy Research

Aim of the Study: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. Materials and Methods: Streptozotocin (STZ)-induced diabetic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f67321b35b7f7260524db82e868b660
https://pubmed.ncbi.nlm.nih.gov/28250659

Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor

Autor: Jean-Pierre Girolami, Jacques Chevalier, Nelly Blaes, Marion Mehrenberger, Ivan Tack, Françoise Praddaude, Eric Cellier, Christiane Pecher, Réjean Couture

Publikováno v: American Journal of Physiology-Renal Physiology. 303:F293-F303

Mesangial matrix expansion is an early lesion leading to glomeruloclerosis and chronic renal diseases. A beneficial effect is achieved with angiotensin I-converting enzyme inhibitors (ACEI), which also favor bradykinin (BK) B2 receptor (B2R) activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3ee62c0be3d401a50844562973a15e
https://doi.org/10.1152/ajprenal.00437.2011

Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

Autor: Anne Gomez-Brouchet, Nelly Blaes, Bernard Frances, Ivan Tack, Lionel Moulédous, Jean-Pierre Girolami, Vincent Minville, Olivier Fourcade

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, 2015, 13 (1), pp.208. ⟨10.1186/s12967-015-0575-0⟩
Journal of Translational Medicine, BioMed Central, 2015, 13 (1), pp.208. ⟨10.1186/s12967-015-0575-0⟩

International audience; AbstractBackgroundDiabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cefca8907219ee34674fa5ef59b52d
https://doi.org/10.1186/s12967-015-0575-0

Genetic manipulation and genetic variation of the kallikrein-kinin system: impact on cardiovascular and renal diseases

Autor: Jean-Pierre, Girolami, Nelly, Blaes, Nadine, Bouby, François, Alhenc-Gelas

Publikováno v: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 69

Genetic manipulation of the kallikrein-kinin system (KKS) in mice, with either gain or loss of function, and study of human genetic variability in KKS components which has been well documented at the phenotypic and genomic level, have allowed recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed7e21075dd19cc9e6c8f60fa6cfbea0
https://pubmed.ncbi.nlm.nih.gov/25130042

Estrogen synthesis, estrogen metabolism, and functional estrogen receptors in rat arterial smooth muscle cells in culture

Autor: Francis Bayard, Nelly Blaes, Georges Delsol, Simone Clamens, Fabienne Meggetto, Jean-Charles Faye

Publikováno v: Endocrinology. 136:1523-1529

To investigate the mechanisms by which estrogen hormones influence the vascular system, the metabolism of these hormones and the functionality of estrogen receptors were characterized in rat aortic smooth muscle cells from secondary cultures, a widel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8db00424bcb04b4435ab9272916dfef
https://doi.org/10.1210/endo.136.4.7895662