Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nelly A. Kuklin"'
Autor:
Samnang Tep, Radu Mihaila, Alexander Freeman, Victoria Pickering, Felicia Huynh, Marija Tadin-Strapps, Allison Stracks, Brian Hubbard, Jeremy Caldwell, W. Michael Flanagan, Nelly A. Kuklin, Brandon Ason
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 859-867 (2012)
Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver stea
Externí odkaz:
https://doaj.org/article/fdcfd415604344018fb272350374bf38
Autor:
Brandon Ason, Samnang Tep, Jr. Harry R. Davis, Yiming Xu, Glen Tetzloff, Beverly Galinski, Ferdie Soriano, Natalya Dubinina, Lei Zhu, Alice Stefanni, Kenny K. Wong, Marija Tadin-Strapps, Steven R. Bartz, Brian Hubbard, Mollie Ranalletta, Alan B. Sachs, W. Michael Flanagan, Alison Strack, Nelly A. Kuklin
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 679-687 (2011)
Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blo
Externí odkaz:
https://doaj.org/article/5914edaf91c54338b6cfc9ad1842ba30
Autor:
R. Matthew Haas, Jing Kang, W. Michael Flanagan, Dipali Ruhela, Nelly A. Kuklin, Samnang Tep, Radu Mihaila, Elena Cherkaev, Jeremy Caldwell, Ananda Card, Timothy R. Shadel, Jie Wei, Brandon Ason, Beverly Galinski, Mark T. Cancilla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss, Pp 367-377 (2019)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely used to selectively
Autor:
Felicia Huynh, Brandon Ason, Jeremy Caldwell, Brian K. Hubbard, Samnang Tep, Victoria Pickering, Marija Tadin-Strapps, Alexander Freeman, Nelly A. Kuklin, W. Michael Flanagan, Radu Mihaila, Allison Stracks
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 859-867 (2012)
Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver stea
Autor:
Radu Mihaila, Elmer Payson, Silvia Chang, Nelly A. Kuklin, Zhi Y. Hu, Sven Duenwald, James J. Cunningham, David J. Mathre, Timothy R. Shadel, Dipali Ruhela, Alan T. Wei
Publikováno v:
International Journal of Pharmaceutics. 420:118-121
This paper describes the use of spin centrifugation-dialysis (SCD) for small-scale concentration/purification of siRNA-lipid complexes designed for use as therapeutic agents for gene silencing. SCD consists of a two-step method for concentration, fil
Autor:
W. Michael Flanagan, Samnang Tep, Brian K. Hubbard, Alice C. Stefanni, Thomas P. Roddy, Alan B. Sachs, Thomas Hankemeier, Brandon Ason, Nelly A. Kuklin, Jose Castro-Perez, Lyndon J. Mitnaul, Marija Tadin-Strapps
Publikováno v:
Lipids
The association between hypercholesterolemia and elevated serum apolipoprotein B (APOB) has generated interest in APOB as a therapeutic target for patients at risk of developing cardiovascular disease. In the clinic, mipomersen, an antisense oligonuc
Autor:
Kenny K. Wong, Brian K. Hubbard, Alison M. Strack, Beverly Galinski, Mollie Ranalletta, Lei Zhu, Harry R. Davis, Alice C. Stefanni, Natalya Dubinina, Glen Tetzloff, Samnang Tep, Ferdie Soriano, Yiming Xu, Marija Tadin-Strapps, Brandon Ason, Nelly A. Kuklin, Alan B. Sachs, Steven R. Bartz, W. Michael Flanagan
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 679-687 (2011)
Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blo
Autor:
Elmer Payson, Paula J. Hancock, Yi Pei, Natalya Dubinina, Michael Krimm, Ananda Card, Mark T. Cancilla, Jeffrey P. Jones, Jerome H. Hochman, Nelly A. Kuklin, W. Michael Flanagan, Brandon Ason, Julja Burchard, Jie Wei, Alan B. Sachs, Jing Kang, Mark Stroh
Publikováno v:
Molecular Pharmacology. 79:953-963
Deeper knowledge of pharmacokinetic and pharmacodynamic (PK/PD) concepts for RNA therapeutics is important to streamline the drug development process and for rigorous selection of best performing drug candidates. Here we characterized the PK/PD relat
Autor:
Marc Abrams, Jessica Seitzer, Laura Sepp-Lorenzino, Yi Pei, René Bartz, Paul A. Burke, Nathalie Innocent, Yan Xu, Stanley F. Barnett, Craig Cherrin, Colin J. Pomerantz, Paula J. Hancock, Hangchun Zhang, Martin Koser, Alan B. Sachs, Nelly A. Kuklin
Publikováno v:
RNA. 16:2553-2563
Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy
Autor:
Charles Tan, Xin-Min Wang, Jan Onishi, Joseph G. Joyce, Hongxia Fan, Cook James C, Donna L. Montgomery, Robert W. Hepler, Greg Pancari, Leslie D. Cope, Tessie McNeely, Annaliesa S. Anderson, Nelly A. Kuklin
Publikováno v:
Human Vaccines. 5:254-263
Staphylococcus aureus is a clinically important capsule-forming bacterium. The capsule polysaccharide (CPs) occurs as different chemical structures depending on the serotype of the organism, but one form, capsular polysaccharide type 8 (CPs8) found i