Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Nello, Mainolfi"'
Autor:
Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion
Externí odkaz:
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
Publikováno v:
Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. :372-379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c20ba92b02494c173f546445ec3075f
https://doi.org/10.1002/9781119819950.ch26
https://doi.org/10.1002/9781119819950.ch26
Autor:
Michael E. Pacold, Lewis C. Cantley, Matthias Mann, Eva Hernando, Matthew G. Vander Heiden, Michael A. Davies, Kayvan R. Keshari, Rakesh K. Jain, Jean J. Zhao, Min Yu, Drew R. Jones, David M. Sabatini, Mark Manfredi, Adam Friedman, Vipin Suri, Nello Mainolfi, John H. Healey, Paolo Cotzia, Matija Snuderl, Samuel F. Bakhoum, Benjamin D. Stein, Roshan K. Sriram, Sarah Bacha, Edward R. Kastenhuber, Vinagolu K. Rajasekhar, Ariana Plasger, Jing Ni, Diane S. Kang, Roozbeh Eskandari, Grant M. Fischer, Gino B. Ferraro, Ahmed Ali, Shawn M. Davidson, Alba Luengo, Roger J. Liang, Sophia Bustraan, Sophia Doll, Victoria Osorio-Vasquez, Eugenie Kim, Bryan Ngo
Supplementary Figures and a Supplementary Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda6631052d9083df40c06605fff1966
https://doi.org/10.1158/2159-8290.22536382
https://doi.org/10.1158/2159-8290.22536382
Autor:
Michael E. Pacold, Lewis C. Cantley, Matthias Mann, Eva Hernando, Matthew G. Vander Heiden, Michael A. Davies, Kayvan R. Keshari, Rakesh K. Jain, Jean J. Zhao, Min Yu, Drew R. Jones, David M. Sabatini, Mark Manfredi, Adam Friedman, Vipin Suri, Nello Mainolfi, John H. Healey, Paolo Cotzia, Matija Snuderl, Samuel F. Bakhoum, Benjamin D. Stein, Roshan K. Sriram, Sarah Bacha, Edward R. Kastenhuber, Vinagolu K. Rajasekhar, Ariana Plasger, Jing Ni, Diane S. Kang, Roozbeh Eskandari, Grant M. Fischer, Gino B. Ferraro, Ahmed Ali, Shawn M. Davidson, Alba Luengo, Roger J. Liang, Sophia Bustraan, Sophia Doll, Victoria Osorio-Vasquez, Eugenie Kim, Bryan Ngo
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582a473e89b095f751a52c1fc41c9747
https://doi.org/10.1158/2159-8290.c.6548131.v1
https://doi.org/10.1158/2159-8290.c.6548131.v1
Autor:
Vipin Suri, Mylène Tajan, Owen J. Sansom, Vivian S. W. Li, Rachel A. Ridgway, Laura Novellasdemunt, Eric C. Cheung, Robert L. Ludwig, Marc Hennequart, Nathalie Legrave, Nicola Valeri, Georgios Vlachogiannis, Fabio Zani, Andreas K. Hock, Alejandro Suárez-Bonnet, Nello Mainolfi, Karen Blyth, Mark Manfredi, Adam L. Friedman, Nikolaos Angelis, Karen H. Vousden, Oliver D. K. Maddocks, Dimitris Athineos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f606433f50b018c4e02014a01e9a1511
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
Autor:
Edward R. Kastenhuber, John H. Healey, Lewis C. Cantley, Michael E. Pacold, Paolo Cotzia, Diane Kang, Min Yu, Mark Manfredi, Gino B. Ferraro, Nello Mainolfi, Benjamin D. Stein, Rakesh K. Jain, Matija Snuderl, Roozbeh Eskandari, Alba Luengo, Sophia Doll, Eugenie Kim, Shawn M. Davidson, Roshan K. Sriram, Kayvan R. Keshari, Vipin Suri, Bryan Ngo, David M. Sabatini, Sarah Bacha, Jing Ni, Michael A. Davies, Samuel F. Bakhoum, Roger Liang, Eva Hernando, Ahmed Ali, Ariana Plasger, Victoria Osorio-Vasquez, Drew R. Jones, Matthias Mann, Jean J. Zhao, Vinagolu K. Rajasekhar, Matthew G. Vander Heiden, Sophia Bustraan, Adam Friedman, Grant M. Fischer
Publikováno v:
Cancer Discov
PMC
PMC
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b92864144a321a889f7423c4a44cf37
https://doi.org/10.1158/2159-8290.cd-19-1228
https://doi.org/10.1158/2159-8290.cd-19-1228
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870
https://doi.org/10.1021/acs.jmedchem.9b01870
Publikováno v:
Drug Discovery Today: Technologies. 31:53-60
Targeted protein degradation mediated by small molecule degraders represents an exciting new therapeutic opportunity to eliminate disease-causing proteins. These molecules recruit E3 ubiquitin ligases to the protein of interest and mediate its ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c825ffc19ab4760f0dc2066f8ba3a04
https://doi.org/10.1016/j.ddtec.2019.01.001
https://doi.org/10.1016/j.ddtec.2019.01.001
Autor:
Jeffrey Sullivan, Crystal Brown, Michele Mayo, Vaishali Dixit, Bradley Enerson, Haojing Rong, Bin Yang, Chris De Savi, Jared Gollob, Nello Mainolfi, Anthony Slavin, Cedric Hubeau
Publikováno v:
The Journal of Immunology. 208:60.07-60.07
Signal transducer and activator of transcription 3 (STAT3), an “undruggable” transcription factor activated by a variety of receptor- and non-receptor tyrosine kinases, plays a critical role in activation pathways triggered by cytokines, hormones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33cf0b326918837caa79bf3794ddacc4
https://doi.org/10.4049/jimmunol.208.supp.60.07
https://doi.org/10.4049/jimmunol.208.supp.60.07
Autor:
Stephanie M Skouras, Virginia Massa, Emily Lurier, Cedric Hubeau, Amy Wang, Xiaozhang Zheng, Kirti Sharma, Dirk Walter, Chris Browne, Michele Mayo, Michael Fitzgerald, Alice McDonald, Jared Gollob, Nello Mainolfi, Anthony Slavin, Veronica Campbell
Publikováno v:
The Journal of Immunology. 208:111.13-111.13
IL-1R/TLR activation plays a central role in the pathophysiology of multiple autoimmune and inflammatory diseases via the Myddosome that is dependent on both the kinase and scaffolding functions of Interleukin-1 receptor associated kinase 4 (IRAK4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a25b1cc1876574c6f9abbd617ff99f5
https://doi.org/10.4049/jimmunol.208.supp.111.13
https://doi.org/10.4049/jimmunol.208.supp.111.13